Search Results - "Need, Eleanor"

Androgen receptor coregulators and their involvement in the development and progression of prostate cancer by Chmelar, Renée, Buchanan, Grant, Need, Eleanor F., Tilley, Wayne, Greenberg, Norman M.

“…The androgen receptor signaling axis plays an essential role in the development, function and homeostasis of male urogenital structures including the prostate…”
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Hormonal Regulation of the Immune Microenvironment in the Mammary Gland by Need, Eleanor F., Atashgaran, Vahid, Ingman, Wendy V., Dasari, Pallave

“…It is well established that the development and homeostasis of the mammary gland are highly dependent upon the actions of ovarian hormones progesterone and…”
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Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling by Thornton, Joseph W., Need, Eleanor, Crews, David

“…Receptors for sex and adrenal steroid hormones are absent from fully sequenced invertebrate genomes and have not been recovered from other invertebrates. Here…”
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Research Resource: Interplay between the Genomic and Transcriptional Networks of Androgen Receptor and Estrogen Receptor α in Luminal Breast Cancer Cells by Need, Eleanor F, Selth, Luke A, Harris, Tiffany J, Birrell, Stephen N, Tilley, Wayne D, Buchanan, Grant

“…The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of…”
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Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome by Leach, Damien A, Need, Eleanor F, Toivanen, Roxanne, Trotta, Andrew P, Palethorpe, Helen M, Palenthorpe, Helen M, Tamblyn, David J, Kopsaftis, Tina, England, Georgina M, Smith, Eric, Drew, Paul A, Pinnock, Carole B, Lee, Peng, Holst, Jeff, Risbridger, Gail P, Chopra, Samarth, DeFranco, Donald B, Taylor, Renea A, Buchanan, Grant

“…Androgen receptor (AR) signaling in stromal cells is important in prostate cancer, yet the mechanisms underpinning stromal AR contribution to disease…”
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The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype by Need, Eleanor F, Selth, Luke A, Trotta, Andrew P, Leach, Damien A, Giorgio, Lauren, O'Loughlin, Melissa A, Smith, Eric, Gill, Peter G, Ingman, Wendy V, Graham, J Dinny, Buchanan, Grant

“…In breast cancer, progesterone receptor (PR) positivity or abundance is positively associated with survival and treatment response. It was initially believed…”
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Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts by Leach, Damien A., Need, Eleanor F., Trotta, Andrew P., Grubisha, Melanie J., DeFranco, Donald B., Buchanan, Grant

“…•First global perspective of coregulator effects on AR action in fibroblasts.•Hic-5 has mixed regulatory affects on AR activity.•Androgen inhibits fibroblast…”
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Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation by Trotta, Andrew P., Need, Eleanor F., Selth, Luke A., Chopra, Samarth, Pinnock, Carole B., Leach, Damien A., Coetzee, Gerhard A., Butler, Lisa M., Tilley, Wayne D., Buchanan, Grant

“…Solid tumors have an increased reliance on Hsp70/Hsp90 molecular chaperones for proliferation, survival and maintenance of intracellular signaling systems. An…”
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Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma by Smith, Eric, Palethorpe, Helen M., Ruszkiewicz, Andrew R., Edwards, Suzanne, Leach, Damien A., Underwood, Tim J., Need, Eleanor F., Drew, Paul A.

“…Background Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. Aims To examine the expression and clinical correlates…”
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The prognostic value of stromal FK506‐binding protein 1 and androgen receptor in prostate cancer outcome by Leach, Damien A., Trotta, Andrew P., Need, Eleanor F., Risbridger, Gail P., Taylor, Renea A., Buchanan, Grant

“…BACKGROUND Improving our ability to predict cancer progression and response to conservative or radical intent therapy is critical if we are to prevent under or…”
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Low-Bandgap Conjugated Polymer Dots for Near-Infrared Fluorescence Imaging by Rohatgi, Charu V, Harada, Takaaki, Need, Eleanor F, Krasowska, Marta, Beattie, David A, Dickenson, Gareth D, Smith, Trevor A, Kee, Tak W

“…Low-bandgap conjugated polymers attract significant research interests because of their broad light absorption spectra in the red and near-infrared regions,…”
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Diamide Linked γ‑Cyclodextrin Dimers as Molecular-Scale Delivery Systems for the Medicinal Pigment Curcumin to Prostate Cancer Cells by Harada, Takaaki, Giorgio, Lauren, Harris, Tiffany J, Pham, Duc-Truc, Ngo, Huy Tien, Need, Eleanor F, Coventry, Brendon J, Lincoln, Stephen F, Easton, Christopher J, Buchanan, Grant, Kee, Tak W

“…Diamide linked γ-cyclodextrin (γ-CD) dimers are proposed as molecular-scale delivery agents for the anticancer agent curcumin…”
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Long Terminal Repeats Act as Androgen-Responsive Enhancers for the PSA-Kallikrein Locus by Lawrence, Mitchell G, Stephens, Carson R, Need, Eleanor F, Lai, John, Buchanan, Grant, Clements, Judith A

“…The androgen receptor (AR) signaling pathway is a common therapeutic target for prostate cancer, because it is critical for the survival of both…”
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Subdomain structure of the co-chaperone SGTA and activity of its androgen receptor client by Trotta, Andrew P, Need, Eleanor F, Butler, Lisa M, Selth, Luke A, O'Loughlin, Melissa A, Coetzee, Gerhard A, Tilley, Wayne D, Buchanan, Grant

“…Ligand-dependent activity of steroid receptors is affected by tetratricopeptide repeat (TPR)-containing co-chaperones, such as small glutamine-rich…”
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TGF-beta signalling and immunity in prostate tumourigenesis by Diener, Kerrilyn R, Need, Eleanor F, Buchanan, Grant, Hayball, John D

“…The TGF-beta's are pleiotropic cytokines that regulate multiple cellular functions. Their role in the prostate is important for normal prostate development and…”
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Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro by Palethorpe, Helen M, Leach, Damien A, Need, Eleanor F, Drew, Paul A, Smith, Eric

“…Fibroblasts express androgen receptor (AR) in the normal prostate and during prostate cancer development. We have reported that loss of AR expression in…”
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Erratum: Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome by Leach, Damien A, Need, Eleanor F, Toivanen, Roxanne, Trotta, Andrew P, Palethorpe, Helen M, Tamblyn, David J, Kopsaftis, Tina, England, Georgina M, Smith, Eric, Drew, Paul A, Pinnock, Carole B, Lee, Peng, Holst, Jeff, Risbridger, Gail P, Chopra, Samarth, DeFranco, Donald B, Taylor, Renea A, Buchanan, Grant

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A Novel Androgen Receptor Amino Terminal Region Reveals Two Classes of Amino/Carboxyl Interaction-Deficient Variants with Divergent Capacity to Activate Responsive Sites in Chromatin by Need, Eleanor F, Scher, Howard I, Peters, Amelia A, Moore, Nicole L, Cheong, Albert, Ryan, Charles J, Wittert, Gary A, Marshall, Villis R, Tilley, Wayne D, Buchanan, Grant

“…The androgen receptor (AR) is an important signaling molecule in multiple tissues, yet its mode of action and cell-specific activities remain enigmatic. AR…”
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Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Δ(4)-tibolone by Bianco-Miotto, Tina, Trotta, Andrew P, Need, Eleanor F, Lee, Alice M C, Ochnik, Aleksandra M, Giorgio, Lauren, Leach, Damien A, Swinstead, Erin E, O'Loughlin, Melissa A, Newman, Michelle R, Birrell, Stephen N, Butler, Lisa M, Harris, Jonathan M, Buchanan, Grant

“…Medroxyprogesterone acetate (MPA) has widely been used in hormone replacement therapy (HRT), and is associated with an increased risk of breast cancer,…”
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Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells by Buchanan, Grant, Need, Eleanor F., Barrett, Jeffrey M., Bianco-Miotto, Tina, Thompson, Vanessa C., Butler, Lisa M., Marshall, Villis R., Tilley, Wayne D., Coetzee, Gerhard A.

“…► Repression by SMRT increases with the length of the polymorphic AR CAG repeat. ► SMRT represses AR agonist activity by binding to both activation functions 1…”
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