Search Results - "Nedospasov, Sergei A."

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors by Lemos, Dario R, Babaeijandaghi, Farshad, Low, Marcela, Chang, Chih-Kai, Lee, Sunny T, Fiore, Daniela, Zhang, Regan-Heng, Natarajan, Anuradha, Nedospasov, Sergei A, Rossi, Fabio M V

“…Tgf-β1 contributes to fibrosis during chronic injury by abrogating Tnf-directed apoptosis of fibro/adipogenic progenitor cells during muscle regeneration…”
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Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF by Wang, Xusheng, Chen, Haiyan, Tian, Ruiyun, Zhang, Yiling, Drutskaya, Marina S., Wang, Chengmei, Ge, Jianfeng, Fan, Zhimeng, Kong, Deqiang, Wang, Xiaoxiao, Cai, Ting, Zhou, Ying, Wang, Jingwen, Wang, Jinmei, Wang, Shan, Qin, Zhihai, Jia, Huanhuan, Wu, Yue, Liu, Jia, Nedospasov, Sergei A., Tredget, Edward E., Lin, Mei, Liu, Jianjun, Jiang, Yuyang, Wu, Yaojiong

“…Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that…”
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Distinct modes of TNF signaling through its two receptors in health and disease by Atretkhany, Kamar‐Sulu N., Gogoleva, Violetta S., Drutskaya, Marina S., Nedospasov, Sergei A.

“…TNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is associated with the development of autoimmune diseases and other pathologies…”
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Nonredundant Function of Soluble LTα₃ Produced by Innate Lymphoid Cells in Intestinal Homeostasis by Kruglov, Andrey A., Grivennikov, Sergei I., Kuprash, Dmitry V., Winsauer, Caroline, Prepens, Sandra, Seleznik, Gitta Maria, Eberl, Gerard, Littman, Dan R., Heikenwalder, Mathias, Tumanov, Alexei V., Nedospasov, Sergei A.

“…Immunoglobulin A (IgA) production at mucosal surfaces contributes to protection against pathogens and controls intestinal microbiota composition. However,…”
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Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice by Piliponsky, Adrian M., Shubin, Nicholas J., Lahiri, Asha K., Truong, Phuong, Clauson, Morgan, Niino, Kerri, Tsuha, Avery L., Nedospasov, Sergei A., Karasuyama, Hajime, Reber, Laurent L., Tsai, Mindy, Mukai, Kaori, Galli, Stephen J.

“…Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short life span, suggesting that they have beneficial roles in…”
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Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming by Dudeck, Jan, Ghouse, Shanawaz Mohammed, Lehmann, Christian H.K., Hoppe, Anja, Schubert, Nadja, Nedospasov, Sergei A., Dudziak, Diana, Dudeck, Anne

“…Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood…”
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Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation by Gubernatorova, Ekaterina O, Gorshkova, Ekaterina A, Namakanova, Olga A, Zvartsev, Ruslan V, Hidalgo, Juan, Drutskaya, Marina S, Tumanov, Alexei V, Nedospasov, Sergei A

“…Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environmental factors and characterized by airflow obstruction,…”
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Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection by Neves, Patricia, Lampropoulou, Vicky, Calderon-Gomez, Elisabeth, Roch, Toralf, Stervbo, Ulrik, Shen, Ping, Kühl, Anja A., Loddenkemper, Christoph, Haury, Matthias, Nedospasov, Sergei A., Kaufmann, Stefan H.E., Steinhoff, Ulrich, Calado, Dinis P., Fillatreau, Simon

“…The myeloid differentiation primary response gene 88 ( Myd88) is critical for protection against pathogens. However, we demonstrate here that MyD88 expression…”
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Therapeutic Potential of Combining IL-6 and TNF Blockade in a Mouse Model of Allergic Asthma by Namakanova, Olga A, Gorshkova, Ekaterina A, Zvartsev, Ruslan V, Nedospasov, Sergei A, Drutskaya, Marina S, Gubernatorova, Ekaterina O

“…Combined anti-cytokine therapy is a promising therapeutic approach for uncontrolled steroid-resistant asthma. In this regard, simultaneous blockade of IL-4 and…”
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Commensal microbiota influence systemic autoimmune responses by Van Praet, Jens T, Donovan, Erin, Vanassche, Inge, Drennan, Michael B, Windels, Fien, Dendooven, Amélie, Allais, Liesbeth, Cuvelier, Claude A, van de Loo, Fons, Norris, Paula S, Kruglov, Andrey A, Nedospasov, Sergei A, Rabot, Sylvie, Tito, Raul, Raes, Jeroen, Gaboriau-Routhiau, Valerie, Cerf-Bensussan, Nadine, Van de Wiele, Tom, Eberl, Gérard, Ware, Carl F, Elewaut, Dirk

“…Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the…”
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Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure by Kroetsch, Jeffrey T., Levy, Andrew S., Zhang, Hangjun, Aschar-Sobbi, Roozbeh, Lidington, Darcy, Offermanns, Stefan, Nedospasov, Sergei A., Backx, Peter H., Heximer, Scott P., Bolz, Steffen-Sebastian

“…Tumour necrosis factor (TNF) is a ubiquitously expressed cytokine with functions beyond the immune system. In several diseases, the induction of TNF expression…”
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Cell-type–restricted anti-cytokine therapy: TNF inhibition from one pathogenic source by Efimov, Grigory A., Kruglov, Andrei A., Khlopchatnikova, Zoya V., Rozov, Fedor N., Mokhonov, Vladislav V., Rose-John, Stefan, Scheller, Jürgen, Gordon, Siamon, Stacey, Martin, Drutskaya, Marina S., Tillib, Sergei V., Nedospasov, Sergei A.

“…Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti- TNF therapy. TNF is produced by…”
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Tristetraprolin expression by keratinocytes controls local and systemic inflammation by Andrianne, Mathieu, Assabban, Assiya, La, Caroline, Mogilenko, Denis, Salle, Delphine Staumont, Fleury, Sébastien, Doumont, Gilles, Van Simaeys, Gaëtan, Nedospasov, Sergei A, Blackshear, Perry J, Dombrowicz, David, Goriely, Stanislas, Van Maele, Laurye

“…Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important cytokines. Due to the critical role of this RNA-binding…”
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Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases by Gubernatorova, Ekaterina O., Namakanova, Olga A., Gorshkova, Ekaterina. A., Medvedovskaya, Alexandra D., Nedospasov, Sergei A., Drutskaya, Marina S.

“…Asthma is a heterogeneous inflammatory disease characterized by airflow obstruction, wheezing, eosinophilia and neutrophilia of the airways. Identification of…”
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SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2 by Astrakhantseva, Irina V, Ershova, Alina E, Chuvpilo, Sergei A, Kruglova, Natalia A, Ishmukhametov, Aydar A, Drutskaya, Marina S, Kozlovskaya, Liubov I, Nedospasov, Sergei A

“…The binding properties of synthetic and recombinant peptides derived from N-terminal part of ACE2, the main receptor for SARS-CoV-2, were evaluated…”
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Akkermansia muciniphila - friend or foe in colorectal cancer? by Gubernatorova, Ekaterina O, Gorshkova, Ekaterina A, Bondareva, Marina A, Podosokorskaya, Olga A, Sheynova, Anna D, Yakovleva, Anastasia S, Bonch-Osmolovskaya, Elizaveta A, Nedospasov, Sergei A, Kruglov, Andrey A, Drutskaya, Marina S

“…is a gram-negative anaerobic bacterium, which represents a part of the commensal human microbiota. Decline in the abundance of among other microbial species in…”
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Lymphotoxin Beta Receptor Signaling in Intestinal Epithelial Cells Orchestrates Innate Immune Responses against Mucosal Bacterial Infection by Wang, Yugang, Koroleva, Ekaterina P., Kruglov, Andrei A., Kuprash, Dmitry V., Nedospasov, Sergei A., Fu, Yang-Xin, Tumanov, Alexei V.

“…Epithelial cells provide the first line of defense against mucosal pathogens; however, their coordination with innate and adaptive immune cells is not well…”
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Current Perspectives on the Role of TNF in Hematopoiesis Using Mice With Humanization of TNF/LT System by Gogoleva, Violetta S., Atretkhany, Kamar-Sulu N., Dygay, Arina P., Yurakova, Taisiya R., Drutskaya, Marina S., Nedospasov, Sergei A.

“…TNF is a multifunctional cytokine with its key functions attributed to inflammation, secondary lymphoid tissue organogenesis and immune regulation. However, it…”
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Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization by Gorshkova, Ekaterina A, Gubernatorova, Ekaterina O, Dvorianinova, Ekaterina M, Yurakova, Taisiya R, Marey, Maria V, Averina, Olga A, Holtze, Susanne, Hildebrandt, Thomas B, Dmitriev, Alexey A, Drutskaya, Marina S, Vyssokikh, Mikhail Yu, Nedospasov, Sergei A

“…The naked mole-rat (NMR) is a unique long-lived rodent which is highly resistant to age-associated disorders and cancer. The immune system of NMR possesses a…”
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Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis by Nosenko, Maxim A, Moysenovich, Anastasia M, Zvartsev, Ruslan V, Arkhipova, Anastasia Y, Zhdanova, Anastasia S, Agapov, Igor I, Vasilieva, Tamara V, Bogush, Vladimir G, Debabov, Vladimir G, Nedospasov, Sergei A, Moisenovich, Mikhail M, Drutskaya, Marina S

“…Despite decades of research, the goal of achieving scarless wound healing remains elusive. One of the approaches, treatment with polymeric microcarriers, was…”
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