Search Results - "Nedjic, Jelena"

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance by Aichinger, Martin, Wu, Chunyan, Nedjic, Jelena, Klein, Ludger

“…Macroautophagy serves cellular housekeeping and metabolic functions through delivery of cytoplasmic constituents for lysosomal degradation. In addition, it may…”
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Autophagy and T-cell education in the thymus: Eat yourself to know yourself by Nedjic, Jelena, Aichinger, Martin, Klein, Ludger

“…During intrathymic generation of the T cell repertoire, a series of selection processes ensure that only self-MHC (Major Histocompatibility Complex) restricted…”
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A novel role for autophagy in T cell education by Nedjic, Jelena, Aichinger, Martin, Klein, Ludger

“…During T cell development in the thymus, scanning of peptide/Major Histocompatibility (MHC) molecule complexes on the surface of thymic epithelial cells…”
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Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction by Yamano, Tomoyoshi, Nedjic, Jelena, Hinterberger, Maria, Steinert, Madlen, Koser, Sandra, Pinto, Sheena, Gerdes, Norbert, Lutgens, Esther, Ishimaru, Naozumi, Busslinger, Meinrad, Brors, Benedikt, Kyewski, Bruno, Klein, Ludger

“…Thymic antigen-presenting cells (APCs) such as dendritic cells and medullary thymic epithelial cells (mTECs) use distinct strategies of self-antigen expression…”
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Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance by Klein, Ludger, Nedjic, Jelena, Aichinger, Martin, Emmerich, Jan, Mizushima, Noboru

“…Recognition of self-antigen-derived epitopes presented by major histocompatibility complex class II (MHC II) molecules on thymic epithelial cells (TECs) is…”
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Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia by Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Welstead, G. Grant, Trimarchi, Thomas, Bakogianni, Sofia, Xu, Luyao, Loizou, Evangelia, Holmfeldt, Linda, Strikoudis, Alexandros, King, Bryan, Mullenders, Jasper, Becksfort, Jared, Nedjic, Jelena, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., Tonon, Giovanni, Satoh, Takashi, Kruidenier, Laurens, Prinjha, Rab, Akira, Shizuo, Van Vlierberghe, Pieter, Ferrando, Adolfo A., Jaenisch, Rudolf, Mullighan, Charles G., Aifantis, Iannis

“…T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3…”
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Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83 by von Rohrscheidt, Julia, Petrozziello, Elisabetta, Nedjic, Jelena, Federle, Christine, Krzyzak, Lena, Ploegh, Hidde L, Ishido, Satoshi, Steinkasserer, Alexander, Klein, Ludger

“…Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and -extrinsic functions…”
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Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool by Vahl, J. Christoph, Drees, Christoph, Heger, Klaus, Heink, Sylvia, Fischer, Julius C., Nedjic, Jelena, Ohkura, Naganari, Morikawa, Hiromasa, Poeck, Hendrik, Schallenberg, Sonja, Rieß, David, Hein, Marco Y., Buch, Thorsten, Polic, Bojan, Schönle, Anne, Zeiser, Robert, Schmitt-Gräff, Annette, Kretschmer, Karsten, Klein, Ludger, Korn, Thomas, Sakaguchi, Shimon, Schmidt-Supprian, Marc

“…Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and autoimmune responses. During development, thymocytes bearing a moderately…”
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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia by Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Vlierberghe, Pieter Van, Nedjic, Jelena, Trimarchi, Thomas, Flaherty, Maria Sol, Ferres-Marco, Dolors, da Ros, Vanina, Tang, Zuojian, Siegle, Jasmin, Asp, Patrik, Hadler, Michael, Rigo, Isaura, Keersmaecker, Kim De, Patel, Jay, Huynh, Tien, Utro, Filippo, Poglio, Sandrine, Samon, Jeremy B, Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M, Rabadan, Raul, Levine, Ross L, Brown, Stuart, Pflumio, Francoise, Dominguez, Maria, Ferrando, Adolfo, Aifantis, Iannis

“…T cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling 1 . In this study…”
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RNA-binding proteins come out of the shadows by Nedjic, Jelena, Aifantis, Iannis

“…Notch1 has an indispensable role in T cell development and NOTCH1 acts as a potent oncogene in T cell leukemia. New data now reveal the role of RNA-binding…”
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RNA-binding proteins come out of the shadows: Notch1 has an indispensable role in T cell development and NOTCH1 acts as a potent oncogene in T cell leukemia. New data now reveal the role of RNA-binding proteins in regulating the stability of Notch1 mRNA and the induction of T cell leukemia by Nedjic, Jelena, Aifantis, Iannis

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Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance by Wu, Chunyan, Aichinger, Martin, Nedjic, Jelena, Klein, Ludger

“…During development in the thymus, each T lymphocyte is equipped with one, essentially unique, T cell receptor (TCR)-specificity. Due to its random nature, this…”
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Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance by Aichinger, Martin, Wu, Chunyan, Nedjic, Jelena, Klein, Ludger

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Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules by Nedjic, Jelena, Aichinger, Martin, Mizushima, Noboru, Klein, Ludger

“…Functional and biochemical assays indicate a substantial contribution of intracellularly derived peptides to the MHC class II ‘ligandome’. Macroautophagy, a…”
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Gut-resident CX3CR1 hi macrophages induce tertiary lymphoid structures and IgA response in situ by Koscsó, Balázs, Kurapati, Sravya, Rodrigues, Richard R, Nedjic, Jelena, Gowda, Kavitha, Shin, Changsik, Soni, Chetna, Ashraf, Azree Zaffran, Purushothaman, Indira, Palisoc, Maryknoll, Xu, Sulei, Sun, Haoyu, Chodisetti, Sathi Babu, Lin, Eugene, Mack, Matthias, Kawasawa, Yuka Imamura, He, Pingnian, Rahman, Ziaur S M, Aifantis, Iannis, Shulzhenko, Natalia, Morgun, Andrey, Bogunovic, Milena

“…Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the initiation of immune…”
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Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia by Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Van Vlierberghe, Pieter, Nedjic, Jelena, Trimarchi, Thomas, Flaherty, Maria Sol, Ferres-Marco, Dolors, da Ros, Vanina, Tang, Zuojian, Siegle, Jasmin, Asp, Patrik, Hadler, Michael, Rigo, Isaura, De Keersmaecker, Kim, Patel, Jay, Huynh, Tien, Utro, Filippo, Poglio, Sandrine, Samon, Jeremy B., Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M., Rabadan, Raul, Levine, Ross L., Brown, Stuart, Pflumio, Francoise, Dominguez, Maria, Ferrando, Adolfo, Aifantis, Iannis

“…T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling 1 . In this study…”
Get full text