Search Results - "Nedergaard, Jan"

The Browning of White Adipose Tissue: Some Burning Issues by Nedergaard, Jan, Cannon, Barbara

“…Igniting thermogenesis within white adipose tissue (i.e., promoting expression and activity of the uncoupling protein UCP1) has attracted much interest…”
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Nonshivering thermogenesis and its adequate measurement in metabolic studies by Cannon, Barbara, Nedergaard, Jan

“…Alterations in nonshivering thermogenesis are presently discussed as being both potentially causative of and able to counteract obesity. However, the necessity…”
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Unexpected evidence for active brown adipose tissue in adult humans by Nedergaard, Jan, Bengtsson, Tore, Cannon, Barbara

“…The contention that brown adipose tissue is absent in adult man has meant that processes attributed to active brown adipose tissue in experimental animals…”
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Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study by Fischer, Alexander W, Cannon, Barbara, Nedergaard, Jan

“…The laboratory mouse is presently the most common model for examining mechanisms of human physiology and disease. Housing temperatures can have a large impact…”
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Brown Adipose Tissue: Function and Physiological Significance by CANNON, BARBARA, NEDERGAARD, JAN

“…The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue:…”
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UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality by Feldmann, Helena M., Golozoubova, Valeria, Cannon, Barbara, Nedergaard, Jan

“…As original studies of UCP1-ablated mice failed to demonstrate an obesogenic effect, alternative mechanisms for adaptive adrenergic thermogenesis have been…”
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New Powers of Brown Fat: Fighting the Metabolic Syndrome by Nedergaard, Jan, Bengtsson, Tore, Cannon, Barbara

“…An understanding of the full powers of brown adipose tissue (BAT) is only successively being accumulated. In a paper in Nature Medicine, Bartelt et al. (2011)…”
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Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues by Waldén, Tomas B, Hansen, Ida R, Timmons, James A, Cannon, Barbara, Nedergaard, Jan

“…Mainly from cell culture studies, a series of genes that have been suggested to be characteristic of different types of adipocytes have been identified. Here…”
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Intact innervation is essential for diet-induced recruitment of brown adipose tissue by Fischer, Alexander W, Schlein, Christian, Cannon, Barbara, Heeren, Joerg, Nedergaard, Jan

“…The possibility that recruitment and activation of brown adipose tissue (BAT) thermogenesis could be beneficial for curtailing obesity development in humans…”
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A stringent validation of mouse adipose tissue identity markers by de Jong, Jasper M A, Larsson, Ola, Cannon, Barbara, Nedergaard, Jan

“…The nature of brown adipose tissue in humans is presently debated: whether it is classical brown or of brite/beige nature. The dissimilar developmental origins…”
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Perfluorooctanoate (PFOA) cell-autonomously promotes thermogenic and adipogenic differentiation of brown and white adipocytes by Reckziegel, Patrícia, Petrovic, Natasa, Cannon, Barbara, Nedergaard, Jan

“…Perfluorooctanoic acid (PFOA) is a synthetic organofluoride surfactant associated with several toxic effects in humans and animals. Particularly, it has been…”
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Genetic and functional characterization of clonally derived adult human brown adipocytes by Shinoda, Kosaku, Luijten, Ineke H N, Hasegawa, Yutaka, Hong, Haemin, Sonne, Si B, Kim, Miae, Xue, Ruidan, Chondronikola, Maria, Cypess, Aaron M, Tseng, Yu-Hua, Nedergaard, Jan, Sidossis, Labros S, Kajimura, Shingo

“…Clonally-derived cell lines of human preadipocytes from BAT biopsies allows for the genetic and functional characterization of adipocytes from this tissue…”
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At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1 by Dittner, Claudia, Lindsund, Erik, Cannon, Barbara, Nedergaard, Jan

“…Hyperthyroidism is associated with increased metabolism (“thyroid thermogenesis”) and elevated body temperature, often referred to as hyperthermia. Uncoupling…”
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Thermogenesis challenges the adipostat hypothesis for body-weight control by Cannon, Barbara, Nedergaard, Jan

“…According to the adipostat hypothesis for body-weight control, alterations in body weight should always be compensated by adequate alterations in food intake…”
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Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis? by Luijten, Ineke H.N., Cannon, Barbara, Nedergaard, Jan

“…A reduction in the thermogenic activity of brown adipose tissue (BAT) is presently discussed as a possible determinant for the development of obesity in…”
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UCP1 is essential for adaptive adrenergic nonshivering thermogenesis by Golozoubova, Valeria, Cannon, Barbara, Nedergaard, Jan

“…Participation of brown adipose tissue [through the action of the uncoupling protein-1 (UCP1)] in adaptive adrenergic nonshivering thermogenesis is recognized,…”
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Human brown adipose tissue: Classical brown rather than brite/beige? by Cannon, Barbara, Jong, Jasper M. A., Fischer, Alexander W., Nedergaard, Jan, Petrovic, Natasa

“…New Findings What is the topic of this review? It has been suggested that human brown adipose tissue (BAT) is more similar to the brite/beige adipose tissue of…”
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Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure by Wikstrom, Jakob D, Mahdaviani, Kiana, Liesa, Marc, Sereda, Samuel B, Si, Yaguang, Las, Guy, Twig, Gilad, Petrovic, Natasa, Zingaretti, Cristina, Graham, Adam, Cinti, Saverio, Corkey, Barbara E, Cannon, Barbara, Nedergaard, Jan, Shirihai, Orian S

“…Adrenergic stimulation of brown adipocytes (BA) induces mitochondrial uncoupling, thereby increasing energy expenditure by shifting nutrient oxidation towards…”
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Glucocorticoid-Induced Obesity Develops Independently of UCP1 by Luijten, Ineke H.N., Brooks, Katie, Boulet, Nathalie, Shabalina, Irina G., Jaiprakash, Ankita, Carlsson, Bo, Fischer, Alexander W., Cannon, Barbara, Nedergaard, Jan

“…An excess of glucocorticoids leads to the development of obesity in both mice and humans, but the mechanism for this is unknown. Here, we determine the extent…”
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Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor γ in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression by Siersbæk, Majken S., Loft, Anne, Aagaard, Mads M., Nielsen, Ronni, Schmidt, Søren F., Petrovic, Natasa, Nedergaard, Jan, Mandrup, Susanne

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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