Search Results - "Nedelcu, M."

The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment by Paul, Doru, Nedelcu, Aurora M

“…In order to effectively manage and cure cancer we should move beyond the general view of cancer as a random process of genetic alterations leading to…”
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Co-option during the evolution of multicellular and developmental complexity in the volvocine green algae by Olson, Bradley JSC, Nedelcu, Aurora M

“…Despite its major impact on the evolution of Life on Earth, the transition to multicellularity remains poorly understood, especially in terms of its genetic…”
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In vitro evidence for the potential of EGFR inhibitors to decrease the TGF-β1-induced dispersal of circulating tumour cell clusters mediated by EGFR overexpression by Hapeman, Jorian D., Galwa, Rakshit, Carneiro, Caroline S., Nedelcu, Aurora M.

“…Most cancer-related deaths are due to the spread of tumour cells throughout the body—a process known as metastasis. While in the vasculature, these cells are…”
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Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities by Tissot, Sophie, Meliani, Jordan, Chee, Matthew, Nedelcu, Aurora M., Boutry, Justine, Tökölyi, Jácint, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Thomas, Frédéric, Dujon, Antoine M.

“…Recent theoretical advances in the One Health approach have suggested that cancer pathologies should be given greater consideration, as cancers often render…”
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ON THE PARADIGM OF ALTRUISTIC SUICIDE IN THE UNICELLULAR WORLD by Nedelcu, Aurora M., Driscoll, William W., Durand, Pierre M., Herron, Matthew D., Rashidi, Armin

“…Altruistic suicide is best known in the context of programmed cell death (PCD) in multicellular individuals, which is understood as an adptive process that…”
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The Plastid Genome of Polytoma uvella Is the Largest Known among Colorless Algae and Plants and Reflects Contrasting Evolutionary Paths to Nonphotosynthetic Lifestyles by Figueroa-Martinez, Francisco, Nedelcu, Aurora M., Smith, David R., Reyes-Prieto, Adrian

“…The loss of photosynthesis is frequently associated with parasitic or pathogenic lifestyles, but it also can occur in free-living, plastid-bearing lineages. A…”
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Author Correction: The impact of food availability on tumorigenesis is evolutionarily conserved by Tissot, Sophie, Guimard, Lena, Meliani, Jordan, Boutry, Justine, Dujon, Antoine M., Capp, Jean-Pascal, Tökölyi, Jácint, Biro, Peter A., Beckmann, Christa, Fontenille, Laura, Do Khoa, Nam, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Nedelcu, Aurora M., Thomas, Frédéric

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The impact of food availability on tumorigenesis is evolutionarily conserved by Tissot, Sophie, Guimard, Lena, Meliani, Jordan, Boutry, Justine, Dujon, Antoine M., Capp, Jean-Pascal, Tökölyi, Jácint, Biro, Peter A., Beckmann, Christa, Fontenille, Laura, Do Khoa, Nam, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Nedelcu, Aurora M., Thomas, Frédéric

“…The inability to control cell proliferation results in the formation of tumors in many multicellular lineages. Nonetheless, little is known about the extent of…”
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In Vitro Model-Systems to Understand the Biology and Clinical Significance of Circulating Tumor Cell Clusters by May, Alexander N, Crawford, Bryan D, Nedelcu, Aurora M

“…The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary…”
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The paradox of cooperation among selfish cancer cells by Capp, Jean‐Pascal, Thomas, Frédéric, Marusyk, Andriy, M. Dujon, Antoine, Tissot, Sophie, Gatenby, Robert, Roche, Benjamin, Ujvari, Beata, DeGregori, James, Brown, Joel S., Nedelcu, Aurora M.

“…It is traditionally assumed that during cancer development, tumor cells abort their initially cooperative behavior (i.e., cheat) in favor of evolutionary…”
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A model for the dissemination of circulating tumour cell clusters involving platelet recruitment and a plastic switch between cooperative and individual behaviours by Hapeman, Jorian D, Carneiro, Caroline S, Nedelcu, Aurora M

“…Abstract Background In spite of extensive research, cancer remains a major health problem worldwide. As cancer progresses, cells acquire traits that allow them…”
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When the lights go out: the evolutionary fate of free‐living colorless green algae by Figueroa‐Martinez, Francisco, Nedelcu, Aurora M, Smith, David R, Reyes‐Prieto, Adrian

“…The endosymbiotic origin of plastids was a launching point for eukaryotic evolution. The autotrophic abilities bestowed by plastids are responsible for much of…”
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Group phenotypic composition in cancer by Capp, Jean-Pascal, DeGregori, James, Nedelcu, Aurora M, Dujon, Antoine M, Boutry, Justine, Pujol, Pascal, Alix-Panabières, Catherine, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata, Marusyk, Andriy, Gatenby, Robert, Thomas, Frédéric

“…Although individual cancer cells are generally considered the Darwinian units of selection in malignant populations, they frequently act as members of groups…”
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Environmentally induced responses co-opted for reproductive altruism by Nedelcu, Aurora M.

“…Reproductive altruism is an extreme form of altruism best typified by sterile castes in social insects and somatic cells in multicellular organisms. Although…”
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Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones by Carneiro, Caroline S, Hapeman, Jorian D, Nedelcu, Aurora M

“…Despite intensive research, cancer remains a major health problem. The difficulties in treating cancer reflect the complex nature of this disease, including…”
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Gastric Bypass after multiple restrictive procedures: Roux-en-Y or One Anastomosis? A retrospective multicentric study by Sista, F, Clementi, M, Rivkine, E, Soprani, A, Fiasca, F, Cappelli, S, Montana, L, Nedelcu, M, Carandina, S

“…When restrictive surgery fails, conversion to more malabsorptive techniques is frequently proposed. The aim of this study is to evaluate the weight loss…”
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Agent‐based modelling reveals strategies to reduce the fitness and metastatic potential of circulating tumour cell clusters by Campenni, Marco, May, Alexander N., Boddy, Amy, Harris, Valerie, Nedelcu, Aurora M.

“…Metastasis—the ability of cancer cells to disperse throughout the body and establish new tumours at distant locations—is responsible for most cancer‐related…”
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Long-term results of laparoscopic gastric sleeve: the importance of follow-up adherence by Sista, F, Carandina, S, Andreica, A, Zulian, V, Pietroletti, R, Cappelli, S, Balla, A, Nedelcu, M, Clementi, M

“…This study was conducted to assess the long-term results of the Laparoscopic Sleeve Gastrectomy (LSG) in patients not compliant with follow-up, and in patients…”
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Life-history evolution and the origin of multicellularity by Michod, Richard E., Viossat, Yannick, Solari, Cristian A., Hurand, Mathilde, Nedelcu, Aurora M.

“…The fitness of an evolutionary individual can be understood in terms of its two basic components: survival and reproduction. As embodied in current theory,…”
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A Model-System to Address the Impact of Phenotypic Heterogeneity and Plasticity on the Development of Cancer Therapies by Jong, Eric D., Chan, Irina C. W., Nedelcu, Aurora M.

“…The main challenges in developing effective anti-cancer therapies stem from the highly complex and heterogeneous nature of cancer, including the presence of…”
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