Search Results - "Nedderman, Angus N R"

SPECIES DIFFERENCES IN THE DISPOSITION OF THE CCR5 ANTAGONIST, UK-427,857, A NEW POTENTIAL TREATMENT FOR HIV by WALKER, Don K, ABEL, Samantha, COMBY, Pierre, MUIRHEAD, Gary J, NEDDERMAN, Angus N. R, SMITH, Dennis A

“…UK-427,857 (4, 4-difluoro- N -{(1 S )-3-[ exo -3-(3-isopropyl-5-methyl-4 H…”
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Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects by Abel, Samantha, Russell, Deborah, Whitlock, Lyndsey A., Ridgway, Caroline E., Nedderman, Angus N. R., Walker, Donald K.

“…AIMS Two studies were conducted to: (i) quantify the amount of drug‐related radioactivity in blood, plasma, urine and faeces following a 14C‐labelled dose of…”
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Metabolites in safety testing: metabolite identification strategies in discovery and development by Nedderman, Angus N. R.

“…The publication of the FDA MIST guidelines in 2008, together with the acknowledged importance of metabolism data for the progression of novel compounds through…”
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Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [14C]Lersivirine to Healthy Volunteers by VOURVAHIS, Manoli, GLEAVE, Michelle, NEDDERMAN, Angus N. R, HYLAND, Ruth, GARDNER, Lain, HOWARD, Martin, KEMPSHALL, Sarah, COLLINS, Claire, LABADIE, Robert

“…Lersivirine [UK-453,061, 5-((3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile] is a next-generation non-nucleoside…”
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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance by Schadt, Simone, Bister, Bojan, Chowdhury, Swapan K, Funk, Christoph, Hop, Cornelis E C A, Humphreys, W Griffith, Igarashi, Fumihiko, James, Alexander D, Kagan, Mark, Khojasteh, S Cyrus, Nedderman, Angus N R, Prakash, Chandra, Runge, Frank, Scheible, Holger, Spracklin, Douglas K, Swart, Piet, Tse, Susanna, Yuan, Josh, Obach, R Scott

“…Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the…”
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Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis by Nedderman, Angus N R, Wright, Pat

“…The publication of the US FDA MIST guidance document in 2008 reignited the debate around the most appropriate strategies to underwrite metabolite safety for…”
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Simultaneous qualitative and quantitative metabolism data generation: a convenient marriage? by Nedderman, Angus N R, Savage, Mark E, Gleave, Michelle, Haynes, Julian J

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From definition to implementation: a cross-industry perspective of past, current and future MIST strategies by Nedderman, Angus N.R., Dear, Gordon J., North, Stephanie, Obach, R. Scott, Higton, David

“…The article describes and discusses the evolution of strategies to characterize metabolites in support of safety studies over the last 40 years, as well as…”
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The use of 96-well Scintiplates to facilitate definitive metabolism studies for drug candidates by Nedderman, Angus N.R, Savage, Mark E, White, Katharine L, Walker, Donald K

“…Semi-quantitative analysis of the drug-related components in biological samples collected during definitive metabolism studies using radiolabelled drug…”
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Preliminary study of the metabolism of 17 alpha-methyltestosterone in horses utilizing gas chromatography-mass spectrometric techniques by Schoene, C, Nedderman, A N, Houghton, E

“…Little is known about the metabolism of 17 alpha-alkyl anabolic steroids in horses. In this study, the metabolism of 17 alpha-methyltestosterone is…”
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Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5- 14 C 2 )-1 H -pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [ 14 C]Lersivirine to Healthy Volunteers by Vourvahis, Manoli, Gleave, Michelle, Nedderman, Angus N. R., Hyland, Ruth, Gardner, Iain, Howard, Martin, Kempshall, Sarah, Collins, Claire, LaBadie, Robert

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Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects: A Review of the Clinical Pharmacology of Maraviroc by ABEL, Samantha, RUSSELL, Deborah, WHITLOCK, Lyndsey A, RIDGWAY, Caroline E, NEDDERMAN, Angus N. R, WALKER, Donald K

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