Search Results - "Nedden, Stephanie zur"

Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents by Bormann, Daniel, Knoflach, Michael, Poreba, Emilia, Riedl, Christian J., Testa, Giulia, Orset, Cyrille, Levilly, Anthony, Cottereau, Andréa, Jauk, Philipp, Hametner, Simon, Stranzl, Nadine, Golabi, Bahar, Copic, Dragan, Klas, Katharina, Direder, Martin, Kühtreiber, Hannes, Salek, Melanie, zur Nedden, Stephanie, Baier-Bitterlich, Gabriele, Kiechl, Stefan, Haider, Carmen, Endmayr, Verena, Höftberger, Romana, Ankersmit, Hendrik J., Mildner, Michael

“…Neuroglia critically shape the brain´s response to ischemic stroke. However, their phenotypic heterogeneity impedes a holistic understanding of the cellular…”
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Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake by Safari, Motahareh Solina, Woerl, Priska, Garmsiri, Carolin, Weber, Dido, Kwiatkowski, Marcel, Hotze, Madlen, Kuenkel, Louisa, Lang, Luisa, Erlacher, Matthias, Gelpi, Ellen, Hainfellner, Johannes A., Baier, Gottfried, Baier-Bitterlich, Gabriele, zur Nedden, Stephanie

“…Glucose-1,6-bisphosphate (G-1,6-BP), a byproduct of glycolysis that is synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in…”
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Protein kinase N1 critically regulates cerebellar development and long-term function by zur Nedden, Stephanie, Eith, Rafaela, Schwarzer, Christoph, Zanetti, Lucia, Seitter, Hartwig, Fresser, Friedrich, Koschak, Alexandra, Cameron, Angus Jm, Parker, Peter J, Baier, Gottfried, Baier-Bitterlich, Gabriele

“…Increasing evidence suggests that synapse dysfunctions are a major determinant of several neurodevelopmental and neurodegenerative diseases. Here we identify…”
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p42/44 MAPK is an essential effector for purine nucleoside-mediated neuroprotection of hypoxic PC12 cells and primary cerebellar granule neurons by Tomaselli, Bettina, Nedden, Stephanie zur, Podhraski, Valerie, Baier-Bitterlich, Gabriele

“…Purine nucleosides protect neurons against hypoxic insult, but the signaling mechanisms have not yet been fully elucidated. We studied the role of the p42/44…”
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Role of PKN1 in Retinal Cell Type Formation by Brunner, Magdalena, Lang, Luisa, Künkel, Louisa, Weber, Dido, Safari, Motahareh Solina, Baier-Bitterlich, Gabriele, Zur Nedden, Stephanie

“…We recently identified PKN1 as a developmentally active gatekeeper of the transcription factor neuronal differentiation-2 (NeuroD2) in several brain areas…”
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Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models by zur Nedden, Stephanie, Safari, Motahareh S., Weber, Dido, Kuenkel, Louisa, Garmsiri, Carolin, Lang, Luisa, Orset, Cyrille, Freret, Tom, Haelewyn, Benoît, Hotze, Madlen, Kwiatkowski, Marcel, Sarg, Bettina, Faserl, Klaus, Savic, Dragana, Skvortsova, Ira-Ida, Krogsdam, Anne, Carollo, Sandro, Trajanoski, Zlatko, Oberacher, Herbert, Zlotek, Dominik, Ostermaier, Florian, Cameron, Angus, Baier, Gottfried, Baier-Bitterlich, Gabriele

“…We recently identified protein kinase N1 (PKN1) as a master regulator of brain development. However, its function in the adult brain has not been clearly…”
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Purine nucleosides: endogenous neuroprotectants in hypoxic brain by Thauerer, Bettina, zur Nedden, Stephanie, Baier-Bitterlich, Gabriele

“…J. Neurochem. (2012) 121, 329–342. Even a short blockade of oxygen flow in brain may lead to the inhibition of oxidative phosphorylation and depletion of…”
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Survival, Treatment Outcome, and Safety of Multiple and Repeated Courses of Stereotactic Body Radiotherapy for Pulmonary Oligometastases of Head and Neck Squamous Cell Carcinoma by Vorbach, Samuel Moritz, Mangesius, Julian, Dejaco, Daniel, Seppi, Thomas, Santer, Matthias, Zur Nedden, Stephanie, Sarcletti, Manuel Paolo, Pointner, Martin Josef, Hart, Tilmann Jakob, Riechelmann, Herbert, Ganswindt, Ute, Nevinny-Stickel, Meinhard

“…Current literature regarding survival and treatment outcome of SBRT in patients with pulmonary oligometastatic head and neck squamous cell carcinoma (HNSCC) is…”
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Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells by Nedden, Stephanie zur, Doney, Alexander S., Frenguelli, Bruno G.

“…Cerebral ischaemia rapidly depletes cellular ATP. Whilst this deprives brain tissue of a valuable energy source, the concomitant production of adenosine…”
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PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic-Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling by Zur Nedden, Stephanie, Safari, Motahareh Solina, Fresser, Friedrich, Faserl, Klaus, Lindner, Herbert, Sarg, Bettina, Baier, Gottfried, Baier-Bitterlich, Gabriele

“…We recently identified protein kinase N1 (PKN1) as a negative gatekeeper of neuronal AKT protein kinase activity during postnatal cerebellar development. The…”
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Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors by zur Nedden, Stephanie, Hawley, Simon, Pentland, Naomi, Hardie, D Grahame, Doney, Alexander S, Frenguelli, Bruno G

“…The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the…”
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PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels by Safari, Motahareh Solina, Obexer, Dido, Baier-Bitterlich, Gabriele, Zur Nedden, Stephanie

“…Alterations in the processes that control α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) expression, assembly and trafficking are…”
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HIF-1 alpha is an essential effector for purine nucleoside-mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons by zur Nedden, Stephanie, Tomaselli, Bettina, Baier-Bitterlich, Gabriele

“…Hypoxia-inducible factor-1 alpha (HIF-1α) and purine nucleosides adenosine and inosine are critical mediators of physiological responses to acute and chronic…”
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Protein Kinase C-Related Kinase (PKN/PRK). Potential Key-Role for PKN1 in Protection of Hypoxic Neurons by Thauerer, Bettina, zur Nedden, Stephanie, Baier-Bitterlich, Gabriele

“…Serine/threonine protein kinase C-related kinase (PKN/PRK) is a family of three isoenzymes (PKN1, PKN2, PKN3), which are widely distributed in eukaryotic…”
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An ion-pair reversed-phase HPLC method for determination of fresh tissue adenine nucleotides avoiding freeze–thaw degradation of ATP by zur Nedden, Stephanie, Eason, Robert, Doney, Alexander S., Frenguelli, Bruno G.

“…Knowledge of the energetic state of tissue is required in a wide range of experimental studies, particularly those investigating the decline and recovery of…”
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Vital role of protein kinase C-related kinase in the formation and stability of neurites during hypoxia by Thauerer, Bettina, zur Nedden, Stephanie, Baier-Bitterlich, Gabriele

“…J. Neurochem. (2010) 113, 432-446. Exposure of pheochromocytoma cells to hypoxia (1% O₂) favors differentiation at the expense of cell viability. Additional…”
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Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A 1 Receptors by zur Nedden, Stephanie, Hawley, Simon, Pentland, Naomi, Hardie, D. Grahame, Doney, Alexander S., Frenguelli, Bruno G.

“…The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the…”
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Targeting the purine salvage pathway in in vitro models of cerebral ischemia by Zur Nedden, Stephanie

“…An interruption of the blood supply to the brain, as occurs during ischemic stroke, results in a rapid decline of ATP levels and a subsequent loss of neuronal…”
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