Search Results - "Neco, Patricia"
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Role of leptin in the pancreatic β-cell: effects and signaling pathways
Published in Journal of molecular endocrinology (01-08-2012)“…Leptin plays an important role in the control of food intake, energy expenditure, metabolism, and body weight. This hormone also has a key function in the…”
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Insulin Hypersecretion in Islets From Diet-Induced Hyperinsulinemic Obese Female Mice Is Associated With Several Functional Adaptations in Individual β-Cells
Published in Endocrinology (Philadelphia) (01-10-2013)“…Insulin resistance and hyperinsulinemia are generally associated with obesity. Obese nondiabetic individuals develop a compensatory β-cell response to adjust…”
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Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes
Published in Molecular and cellular endocrinology (15-03-2015)“…•Pancreatic β-cells from obese ob/ob mice display numerous functional adaptations.•ob/ob β-Cells exhibit enhanced mitochondrial activity in response to…”
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Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity
Published in Scientific reports (25-06-2015)“…Obesity is frequently associated with insulin resistance. To compensate for this situation and maintain normoglycaemia, pancreatic beta-cells undergo several…”
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Myosin II Contributes to Fusion Pore Expansion during Exocytosis
Published in The Journal of biological chemistry (18-04-2008)“…During exocytosis, the fusion pore expands to allow release of neurotransmitters and hormones to the extracellular space. To understand the process of synaptic…”
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New Roles of Myosin II during Vesicle Transport and Fusion in Chromaffin Cells
Published in The Journal of biological chemistry (25-06-2004)“…Modified herpes virus (amplicons) were used to express myosin regulatory light chain (RLC) chimeras with green fluorescent protein (GFP) in cultured bovine…”
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Real-time dynamics of the F-actin cytoskeleton during secretion from chromaffin cells
Published in Journal of cell science (01-07-2005)“…Transmitted light images showed an intricate and dynamic cytoplasmic structural network in cultured bovine chromaffin cells observed under high magnification…”
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RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice
Published in PloS one (2011)“…Ca(2+) mediates the functional coupling between L-type Ca(2+) channel (LTCC) and sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR),…”
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Calcium release domains in mammalian skeletal muscle studied with two-photon imaging and spot detection techniques
Published in The Journal of general physiology (01-06-2006)“…The spatiotemporal characteristics of the Ca(2+) release process in mouse skeletal muscle were investigated in enzymatically dissociated fibers from flexor…”
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Quantitative evaluation of mammalian skeletal muscle as a heterologous protein expression system
Published in Protein expression and purification (01-05-2006)“…The production of mammalian proteins in sufficient quantity and quality for structural and functional studies is a major challenge in biology. Intrinsic…”
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The role of myosin in vesicle transport during bovine chromaffin cell secretion
Published in Biochemical journal (01-12-2002)“…Bovine adrenomedullary cells in culture have been used to study the role of myosin in vesicle transport during exocytosis. Amperometric determination of…”
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L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity
Published in Cardiovascular research (01-03-2016)“…Sino-atrial node (SAN) automaticity is an essential mechanism of heart rate generation that is still not completely understood. Recent studies highlighted the…”
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Decreased Inward-rectifier K+ Current in Myocytes Isolated from a Mouse Model of CPVT
Published in Biophysical journal (01-02-2009)Get full text
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Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin-induced secretion in chromaffin cells
Published in The European journal of neuroscience (01-04-2007)“…Neuroendocrine chromaffin cells were used to study the mechanism of the snake phospholipase A2 (PLA2) neurotoxin enhancement of exocytosis. Notexin,…”
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Differential participation of actin- and tubulin-based vesicle transport systems during secretion in bovine chromaffin cells
Published in The European journal of neuroscience (01-08-2003)“…The role of cytoskeletal elements in vesicle transport occurring during exocytosis was examined in adrenal medullary bovine chromaffin cells maintained in…”
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Taipoxin induces F‐actin fragmentation and enhances release of catecholamines in bovine chromaffin cells
Published in Journal of neurochemistry (01-04-2003)“…Adrenomedullary bovine chromaffin cells were used to study the uptake and cellular effects of the phospholipase type A2 (PLA2) neurotoxin taipoxin in a…”
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Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia: Depressed SAN Automaticity in CPVT
Published in Circulation (New York, N.Y.) (24-07-2012)“…Catecholaminergic polymorphic ventricular tachycardia is characterized by stress-triggered syncope and sudden death. Patients with catecholaminergic…”
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In Vitro Characterization of a Novel N-Terminal CPVT RyR Mutation
Published in Biophysical journal (31-01-2012)Get full text
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