Search Results - "Neckers, Len"

Targeting the dynamic HSP90 complex in cancer by Neckers, Len, Trepel, Jane, Mollapour, Mehdi, Giaccone, Giuseppe

“…Key Points Heat shock protein 90 (HSP90) is a molecular chaperone of numerous oncoproteins. Therefore, cancer cells can be considered to be 'addicted' to this…”
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Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis by Tsutsumi, Shinji, Neckers, Len

“…Heat shock protein 90 (Hsp90) is a molecular chaperone whose association is required for the stability and function of multiple mutated, chimeric and…”
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Heat shock protein 90: its inhibition and function by Zuehlke, Abbey D., Moses, Michael A., Neckers, Len

“…The molecular chaperone heat shock protein 90 (Hsp90) facilitates metastable protein maturation, stabilization of aggregation-prone proteins, quality control…”
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The therapeutic target Hsp90 and cancer hallmarks by Miyata, Yoshihiko, Nakamoto, Hitoshi, Neckers, Len

“…Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role in assisting correct folding and functionality of its client…”
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Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells by WANPING XU, NECKERS, Len

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Using natural product inhibitors to validate Hsp90 as a molecular target in cancer by Neckers, Len

“…Heat shock protein 90 (Hsp90) is a molecular chaperone whose association is required for stability and function of multiple mutated, chimeric, and…”
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Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development by Neckers, Len, Blagg, Brian, Haystead, Timothy, Trepel, Jane B., Whitesell, Luke, Picard, Didier

“…The molecular chaperone Hsp90 is one component of a highly complex and interactive cellular proteostasis network (PN) that participates in protein folding,…”
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Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 by Xu, Wanping, Beebe, Kristin, Chavez, Juan D., Boysen, Marta, Lu, YinYing, Zuehlke, Abbey D., Keramisanou, Dimitra, Trepel, Jane B., Prodromou, Christosomos, Mayer, Matthias P., Bruce, James E., Gelis, Ioannis, Neckers, Len

“…Complex conformational dynamics are essential for function of the dimeric molecular chaperone heat shock protein 90 (Hsp90), including transient, ATP-biased…”
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Inhibition of Cancer Invasion and Metastasis by Targeting the Molecular Chaperone Heat-shock Protein 90 by KOGA, Fumitaka, KIHARA, Kazunori, NECKERS, Len

“…Heat-shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of numerous oncogenic signaling proteins that determine the…”
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Stressing the Development of Small Molecules Targeting HSP90 by NECKERS, Len, TREPEL, Jane B

“…Inhibitors of the molecular chaperone HSP90 have been in clinical development as anticancer agents since 1999. Recent clinical studies, including the work of…”
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The XIth International Online Symposium on Heat Shock Proteins in Biology and Medicine by Calderwood, Stuart K., Repasky, Elizabeth, Neckers, Len, Hightower, Lawrence

“…Single cell and multicellular organisms encounter physical stress from their environment as well as behavioral stress experienced in more complex organisms. As…”
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The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors by Joshi, Abhinav, Ito, Takeshi, Picard, Didier, Neckers, Len

“…The HSP90 paralog TRAP1 was discovered more than 20 years ago; yet, a detailed understanding of the function of this mitochondrial molecular chaperone remains…”
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Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress by Kijima, Toshiki, Prince, Thomas, Neckers, Len, Koga, Fumitaka, Fujii, Yasuhisa

“…The heat shock factor 1 (HSF1) plays a pivotal role in guarding proteome stability or proteostasis by induction of heat shock proteins (HSPs). While HSF1…”
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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation by Kijima, Toshiki, Prince, Thomas L., Tigue, Megan L., Yim, Kendrick H., Schwartz, Harvey, Beebe, Kristin, Lee, Sunmin, Budzynski, Marek A., Williams, Heinric, Trepel, Jane B., Sistonen, Lea, Calderwood, Stuart, Neckers, Len

“…Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program…”
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Tumor Selectivity of Hsp90 Inhibitors: The Explanation Remains Elusive by Chiosis, Gabriela, Neckers, Len

“…Two recent papers attempt to solve both the tumor selectivity and the in vivo tumor accumulation profiles seen with some Hsp90 inhibitors. They spotlight the…”
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The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis by Joshi, Abhinav, Dai, Li, Liu, Yanxin, Lee, Jungsoon, Ghahhari, Nastaran Mohammadi, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa M, Lyons, Gaelyn C, Bernasconi, Lilia, Tsai, Francis T F, Agard, David A, Neckers, Len, Picard, Didier

“…The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of…”
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Heat shock protein 90 as a molecular target for cancer therapeutics by Isaacs, Jennifer S, Xu, Wanping, Neckers, Len

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Hsp90 phosphorylation, Wee1 and the cell cycle by Mollapour, Mehdi, Tsutsumi, Shinji, Neckers, Len

“…Heat Shock Protein 90 (Hsp90) is an essential molecular chaperone in eukaryotic cells, and it maintains the functional conformation of a subset of proteins…”
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An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function by Scroggins, Bradley T., Robzyk, Kenneth, Wang, Dongxia, Marcu, Monica G., Tsutsumi, Shinji, Beebe, Kristin, Cotter, Robert J., Felts, Sara, Toft, David, Karnitz, Larry, Rosen, Neal, Neckers, Len

“…Heat-shock protein 90 (Hsp90) chaperones a key subset of signaling proteins and is necessary for malignant transformation. Hsp90 is subject to an array of…”
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Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells by Tatokoro, Manabu, Koga, Fumitaka, Yoshida, Soichiro, Kawakami, Satoru, Fujii, Yasuhisa, Neckers, Len, Kihara, Kazunori

“…For metastatic bladder cancer patients, systemic cisplatin (CDDP)‐based combination chemotherapy is the first‐line choice of treatment. Although up to 70% of…”
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