Search Results - "Nebreda, Ángel R."

Signal integration by JNK and p38 MAPK pathways in cancer development by Wagner, Erwin F, Nebreda, Ángel R

“…Key Points Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) have important roles in the signalling mechanisms that orchestrate…”
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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor by Eftekharzadeh, Bahareh, Banduseela, Varuna C., Chiesa, Giulio, Martínez-Cristóbal, Paula, Rauch, Jennifer N., Nath, Samir R., Schwarz, Daniel M. C., Shao, Hao, Marin-Argany, Marta, Di Sanza, Claudio, Giorgetti, Elisa, Yu, Zhigang, Pierattelli, Roberta, Felli, Isabella C., Brun-Heath, Isabelle, García, Jesús, Nebreda, Ángel R., Gestwicki, Jason E., Lieberman, Andrew P., Salvatella, Xavier

“…Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens,…”
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The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress by Joaquin, Manel, Gubern, Albert, González-Nuñez, Daniel, Josué Ruiz, E, Ferreiro, Isabel, de Nadal, Eulalia, Nebreda, Angel R, Posas, Francesc

“…The p57 Kip2 cyclin‐dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem‐cell senescence and pathologies, but little is known of its…”
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Age-dependent regulation of antioxidant genes by p38α MAPK in the liver by Pérez, Salvador, Rius-Pérez, Sergio, Tormos, Ana M., Finamor, Isabela, Nebreda, Ángel R., Taléns-Visconti, Raquel, Sastre, Juan

“…p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work…”
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Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor by Eftekharzadeh, Bahareh, Banduseela, Varuna C., Chiesa, Giulio, Martínez-Cristóbal, Paula, Rauch, Jennifer N., Nath, Samir R., Schwarz, Daniel M. C., Shao, Hao, Marin-Argany, Marta, Di Sanza, Claudio, Giorgetti, Elisa, Yu, Zhigang, Pierattelli, Roberta, Felli, Isabella C., Brun-Heath, Isabelle, García, Jesús, Nebreda, Ángel R., Gestwicki, Jason E., Lieberman, Andrew P., Salvatella, Xavier

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Mechanisms and functions of p38 MAPK signalling by Cuadrado, Ana, Nebreda, Angel R

“…The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by…”
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Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis by Curtis, Marion, Kenny, Hilary A., Ashcroft, Bradley, Mukherjee, Abir, Johnson, Alyssa, Zhang, Yilin, Helou, Ynes, Batlle, Raquel, Liu, Xiaojing, Gutierrez, Nuria, Gao, Xia, Yamada, S. Diane, Lastra, Ricardo, Montag, Anthony, Ahsan, Nagib, Locasale, Jason W., Salomon, Arthur R., Nebreda, Angel R., Lengyel, Ernst

“…Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable isotope labeling of amino acids in cell culture coupled with…”
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Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling by Batlle, Raquel, Andrés, Eva, Gonzalez, Lorena, Llonch, Elisabet, Igea, Ana, Gutierrez-Prat, Núria, Berenguer-Llergo, Antoni, Nebreda, Angel R.

“…The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition of the kinase p38α…”
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Roles of p38 MAPKs in invasion and metastasis by del Barco Barrantes, Ivan, Nebreda, Angel R

“…Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade,…”
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Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory by Navarrete, Marta, Cuartero, María I., Palenzuela, Rocío, Draffin, Jonathan E., Konomi, Ainoa, Serra, Irene, Colié, Sandra, Castaño-Castaño, Sergio, Hasan, Mazahir T., Nebreda, Ángel R., Esteban, José A.

“…NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive…”
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Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival by Gupta, Jalaj, del Barco Barrantes, Ivan, Igea, Ana, Sakellariou, Stratigoula, Pateras, Ioannis S., Gorgoulis, Vassilis G., Nebreda, Angel R.

“…Colorectal cancer is frequently associated with chronic inflammation, with the intestinal epithelial barrier playing an important protective role against the…”
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Inhibition of p38 MAPK sensitizes tumour cells to cisplatin‐induced apoptosis mediated by reactive oxygen species and JNK by Pereira, Lorena, Igea, Ana, Canovas, Begoña, Dolado, Ignacio, Nebreda, Angel R.

“…The p38 MAPK pathway is an important regulator of many cellular responses. It is well established that p38 MAPK signalling negatively regulates epithelial cell…”
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Oxidative Stress Is a Central Target for Physical Exercise Neuroprotection Against Pathological Brain Aging by García-Mesa, Yoelvis, Colie, Sandra, Corpas, Rubén, Cristòfol, Rosa, Comellas, Francesc, Nebreda, Angel R, Giménez-Llort, Lydia, Sanfeliu, Coral

“…Physical exercise is suggested for preventing or delaying senescence and Alzheimer's disease (AD). We have examined its therapeutic value in the advanced stage…”
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p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint by Lafarga, Vanesa, Cuadrado, Ana, Lopez de Silanes, Isabel, Bengoechea, Rocio, Fernandez-Capetillo, Oscar, Nebreda, Angel R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer by Jaeger, Samira, Igea, Ana, Arroyo, Rodrigo, Alcalde, Victor, Canovas, Begoña, Orozco, Modesto, Nebreda, Angel R, Aloy, Patrick

“…Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can…”
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Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators by De Mol, Eva, Szulc, Elzbieta, Di Sanza, Claudio, Martínez-Cristóbal, Paula, Bertoncini, Carlos W., Fenwick, R. Bryn, Frigolé-Vivas, Marta, Masín, Marianela, Hunter, Irene, Buzón, Víctor, Brun-Heath, Isabelle, García, Jesús, De Fabritiis, Gianni, Estébanez-Perpiñá, Eva, McEwan, Iain J., Nebreda, Ángel R., Salvatella, Xavier

“…The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription…”
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Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis by Clemente-Ruiz, Marta, Murillo-Maldonado, Juan M., Benhra, Najate, Barrio, Lara, Pérez, Lidia, Quiroga, Gonzalo, Nebreda, Angel R., Milán, Marco

“…Chromosomal instability (CIN) is thought to be a source of mutability in cancer. However, CIN often results in aneuploidy, which compromises cell fitness…”
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Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α by Pous, Joan, Baginski, Blazej, Martin-Malpartida, Pau, González, Lorena, Scarpa, Margherita, Aragon, Eric, Ruiz, Lidia, Mees, Rebeca A., Iglesias-Fernández, Javier, Orozco, Modesto, Nebreda, Angel R., Macias, Maria J.

“…Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents…”
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P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim by Hu, Ping, Nebreda, Angel R., Hanenberg, Helmut, Kinnebrew, Garrett H., Ivan, Mircea, Yoder, Mervin C., Filippi, Marie-Dominique, Broxmeyer, Hal E., Kapur, Reuben

“…While erythropoietin (EPO) constitutes the major treatment for anemia, a range of anemic disorders remain resistant to EPO treatment. The need for alternative…”
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Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression by Warr, Nick, Carre, Gwenn-Aël, Siggers, Pam, Faleato, Jessica Vitos, Brixey, Rachel, Pope, Madeleine, Bogani, Debora, Childers, Melissa, Wells, Sara, Scudamore, Cheryl L., Tedesco, Marianna, del Barco Barrantes, Ivan, Nebreda, Angel R., Trainor, Paul A., Greenfield, Andy

“…Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of…”
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