Search Results - "Nebot, Vicent J"
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Molecular Hydrogels from Bolaform Amino Acid Derivatives: A Structure-Properties Study Based on the Thermodynamics of Gel Solubilization
Published in Chemistry : a European journal (26-03-2012)“…Insight is provided into the aggregation thermodynamics associated to hydrogel formation by molecular gelators derived from L‐valine and L‐isoleucine…”
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Rational Design of Heat-Set and Specific-Ion-Responsive Supramolecular Hydrogels Based on the Hofmeister Effect
Published in Chemistry : a European journal (27-10-2014)“…Smart supramolecular hydrogels have been prepared from a bolaamphiphilic L‐valine derivative in aqueous solutions of different salts. The hydrogels respond…”
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3
Relevant Physicochemical Descriptors of "Soft Nanomedicines" to Bypass Biological Barriers
Published in Current pharmaceutical design (01-01-2016)“…Herein, we present an overview on the current status of the characterization techniques and methodologies used to study the physicochemical descriptors that…”
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Vibrational Circular Dichroism Shows Reversible Helical Handedness Switching in Peptidomimetic l‑Valine Fibrils
Published in The journal of physical chemistry letters (16-08-2012)“…We elucidate the supramolecular organization in the form of microsize fibrils of gels formed by a l-Valine peptidomimetic compound. Analysis was based on…”
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Utility of Triethyloxonium Tetrafluoroborate for Chloride Removal during Sarcosine N‐Carboxyanhydride Synthesis: Improving NCA Purity
Published in Chemistry : a European journal (03-06-2024)“…The clinical translation of polysarcosine (pSar) as polyethylene glycol (PEG) replacement in the development of novel nanomedicines creates a broad demand of…”
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An Offset Patterned Cross‐β Structure in Assemblies of C3‐Symmetric Peptide Amphiphiles
Published in Chemistry : a European journal (01-02-2024)“…Developing peptide‐based materials with controlled morphology is a critical theme of soft matter research. Herein, we report the formation of a novel,…”
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Polypeptide-corticosteroid conjugates as a topical treatment approach to psoriasis
Published in Journal of controlled release (01-02-2020)“…Topical treatment of mild-to-moderate psoriasis with corticosteroids suffers from challenges that include reduced drug bioavailability at the desired site of…”
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Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges
Published in Macromolecular bioscience (01-01-2017)“…Synthetic polypeptides or polyamino acids have become a useful and multifunctional platform in advanced drug delivery studies. Nonetheless, the full potential…”
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Capturing “Extraordinary” Soft‐Assembled Charge‐Like Polypeptides as a Strategy for Nanocarrier Design
Published in Advanced materials (Weinheim) (01-10-2017)“…The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded…”
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Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid‐Based Combination‐Drug Conjugate
Published in Advanced functional materials (30-05-2018)“…Combination nanotherapies for the treatment of breast cancer permits synergistic drug targeting of multiple pathways. However, poor carrier degradability, poor…”
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Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
Published in ACS applied bio materials (18-01-2021)“…Transdermal drug delivery (TDD) is an advantageous and effective approach for the localized delivery of drugs; however, overcoming the high impermeability of…”
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12
Freezing Capture of Polymorphic Aggregates of Bolaamphiphilic L-Valine-Based Molecular Hydrogelators
Published in Chemistry : a European journal (05-05-2014)“…Nanostructured xerogels have been prepared by the freeze‐drying of hydrogels and aggregates formed by bolaamphiphilic L‐valine derivatives after aging under…”
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13
Interplay of Molecular Hydrogelators and SDS Affords Responsive Soft Matter Systems with Tunable Properties
Published in Langmuir (30-07-2013)“…The gelation efficiency of low molecular weight bolaamphiphilic hydrogelators 1 and 2 is influenced by the presence of SDS micelles. Similarly, the critical…”
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Nanocarriers: Capturing “Extraordinary” Soft‐Assembled Charge‐Like Polypeptides as a Strategy for Nanocarrier Design (Adv. Mater. 39/2017)
Published in Advanced materials (Weinheim) (01-10-2017)“…A novel strategy developed by Vicent J. Nebot, María J. Vicent, and co‐workers in article number 1702888 to produce nanosized drug carriers may improve the…”
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Macromol. Biosci. 1/2017
Published in Macromolecular bioscience (01-01-2017)“…Back Cover: Smart design of polypeptide conjugates is based on a complex interplay of physico‐chemical and structural parameters. By careful control of these…”
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Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury
Published in Advanced healthcare materials (01-05-2021)“…While coronary angioplasty represents an effective treatment option following acute myocardial infarction, the reperfusion of the occluded coronary artery can…”
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An Offset Patterned Cross‐β Structure in Assemblies of C 3 ‐Symmetric Peptide Amphiphiles
Published in Chemistry : a European journal (01-02-2024)“…Developing peptide‐based materials with controlled morphology is a critical theme of soft matter research. Herein, we report the formation of a novel,…”
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18
Polypept(o)ides – Origins, synthesis, applications and future directions
Published in Progress in polymer science (01-11-2024)“…Polypept(o)ides combine the stealth-like properties of polypeptoids such as polysarcosine (poly(N-methyl glycine), pSar) with the multifunctionality and…”
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On the Use of Triethyloxonium Tetrafluoroborate for Chloride Removal during Sarcosine N-Carboxyanhydride Synthesis: Improving NCA purity for controlled ring opening polymerization
Published in Chemistry : a European journal (02-04-2024)“…The clinical translation of polysarcosine (pSar) as polyethylene glycol (PEG) replacement in the development of novel nanomedicines creates a broad demand of…”
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20
Water soluble azido polyisocyanopeptides as functional β-sheet mimics
Published in Journal of polymer science. Part A, Polymer chemistry (15-08-2009)“…The design and synthesis of functional biomimetic water soluble polymers with a defined secondary structure has been developed using β-sheet…”
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