Search Results - "Neault, Mathieu"

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy by Binet, François, Cagnone, Gael, Crespo-Garcia, Sergio, Hata, Masayuki, Neault, Mathieu, Dejda, Agnieszka, Wilson, Ariel M., Buscarlet, Manuel, Mawambo, Gaelle Tagne, Howard, Joel P., Diaz-Marin, Roberto, Parinot, Celia, Guber, Vera, Pilon, Frédérique, Juneau, Rachel, Laflamme, Rémi, Sawchyn, Christina, Boulay, Karine, Leclerc, Severine, Abu-Thuraia, Afnan, Côté, Jean-François, Andelfinger, Gregor, Rezende, Flavio A., Sennlaub, Florian, Joyal, Jean-Sébastien, Mallette, Frédérick A., Sapieha, Przemyslaw

“…Remodeling senescent blood vessels The retina is a thin layer of nervous tissue at the back of the eye that transforms light into neuronal signals. The retina…”
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miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells by Neault, Mathieu, Mallette, Frédérick A., Richard, Stéphane

“…Activating K-Ras mutations occurs frequently in pancreatic cancers and is implicated in their development. Cancer-initiating events, such as oncogenic Ras…”
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pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans by Martin, Emmanuel, Harel, Sharon, Nkengfac, Bernard, Hamiche, Karim, Neault, Mathieu, Jenna, Sarah

“…Cell shape changes are crucial for metazoan development. During Caenorhabditis elegans embryogenesis, epidermal cell shape changes transform ovoid embryos into…”
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p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells by Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J., Mallette, Frédérick A., Delisle, Jean-Sébastien

“…T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant…”
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516 Caspase-8 regulated senescence as an immune checkpoint in T lymphocytes for adoptive cell therapy by Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Eve, Sousa, Dave De, Boulet, Salix, Durrieu, Ludovic, Carli, Cedric, Lemieux, Sebastien, Labrecque, Nathalie, Melichar, Heather, Mallette, Frederick, Delisle, Jean-Sebastien

“…BackgroundThe development of immunotherapies holds great promise for the treatment of refractory infections and cancer. Current approaches, although effective…”
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Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis by Fournier, Frédérik, Diaz-Marin, Roberto, Pilon, Frédérique, Neault, Mathieu, Juneau, Rachel, Girouard, Gabrielle, Wilson, Ariel M, Larrivée, Bruno, Mallette, Frédérick A, Crespo-Garcia, Sergio, Sapieha, Przemyslaw

“…Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates…”
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Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor by Neault, Mathieu, Mallette, Frédérick A, Vogel, Gillian, Michaud-Levesque, Jonathan, Richard, Stéphane

“…Arginine methylation of histones is a well-known regulator of gene expression. Protein arginine methyltransferase 6 (PRMT6) has been shown to function as a…”
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Molecular Regulation of Cellular Senescence by MicroRNAs: Implications in Cancer and Age-Related Diseases by Neault, Mathieu, Couteau, Florence, Bonneau, Éric, De Guire, Vincent, Mallette, Frédérick A

“…Cellular senescence is a tumor suppressor response that acts as a barrier to cancer development and progression. In normal cells, diverse stimuli, including…”
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Generation of a Novel Mouse Model Recapitulating Features of Human Acute Megakaryoblastic Leukemia by Lebert-Ghali, Charles-Étienne, Neault, Mathieu, Fournier, Marilaine, Delisle, Jean-Sébastien, Drobetsky, Elliot, Zuber, Johannes, Mallette, Frédérick, Melichar, Heather

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3085 - Generation of a Novel Mouse Model Recapitulating Features of Human Acute Megakaryoblastic Leukemia by Lebert-Ghali, Charles-Étienne, Neault, Mathieu, Fournier, Marilaine, Delisle, Jean-Sébastien, Drobetsky, Elliot, Zuber, Johannes, Mallette, Frédérick, Melichar, Heather

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A MOUSE MODEL OF ACUTE MEGAKARYOBLASTIC LEUKEMIA TO REVEAL NOVEL THERAPEUTIC VULNERABILITIES by Neault, Mathieu, Lebert-Ghali, Charles-Étienne, Fournier, Marilaine, Sawchyn, Christina, Boulay, Karine, Delisle, Jean-Sébastien, Drobetsky, Elliot, Zuber, Johannes, Melichar, Heather, Mallette, Frédérick Antoine

“…Non-down syndrome pediatric acute megakaryoblastic leukemia (AMKL, AML M7; FAB classification) is an aggressive disease, and classical protocols used for the…”
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CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax by Neault, Mathieu, Lebert-Ghali, Charles-Étienne, Fournier, Marilaine, Capdevielle, Caroline, Garfinkle, Elizabeth A.R., Obermayer, Alyssa, Cotton, Anitria, Boulay, Karine, Sawchyn, Christina, St-Amand, Sarah, Nguyen, Kamy H., Assaf, Béatrice, Mercier, François E., Delisle, Jean-Sébastien, Drobetsky, Elliot A., Hulea, Laura, Shaw, Timothy I., Zuber, Johannes, Gruber, Tanja A., Melichar, Heather J., Mallette, Frédérick A.

“…Pediatric acute megakaryoblastic leukemia (AMKL) is an aggressive blood cancer associated with poor therapeutic response and high mortality. Here we describe…”
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Combining Glycomimetic and Multivalent Strategies toward Designing Potent Bacterial Lectin Inhibitors by Chabre, Yoann M., Giguère, Denis, Blanchard, Bertrand, Rodrigue, Jacques, Rocheleau, Sylvain, Neault, Mathieu, Rauthu, Subhash, Papadopoulos, Alex, Arnold, Alexandre A., Imberty, Anne, Roy, René

“…As part of ongoing activities toward the design of potent and selective ligands against galactoside‐binding proteins from animal, bacterial, and plant lectins,…”
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Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation by Huang, Jiawen, Cardamone, M. Dafne, Johnson, Holly E., Neault, Mathieu, Chan, Michelle, Floyd, Z. Elizabeth, Mallette, Frédérick A., Perissi, Valentina

“…G protein pathway suppressor 2 (GPS2) is a multifunctional protein involved in the regulation of a number of metabolic organs. First identified as part of the…”
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Identification of Novel Therapeutic Targets in Acute Megakaryoblastic Leukemia by Neault, Mathieu, Lebert-Ghali, Charles-Étienne, Fournier, Marilaine, Sawchyn, Christina, Boulay, Karine, Samavarchi-Tehrani, Payman, Gingras, Anne-Claude, Delisle, Jean-Sébastien, Drobetsky, Elliot, Zuber, Johannes, Melichar, Heather, Mallette, Frédérick

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3124 - Identification of Novel Therapeutic Targets in Acute Megakaryoblastic Leukemia by Neault, Mathieu, Lebert-Ghali, Charles-Étienne, Fournier, Marilaine, Sawchyn, Christina, Boulay, Karine, Samavarchi-Tehrani, Payman, Gingras, Anne-Claude, Delisle, Jean-Sébastien, Drobetsky, Elliot, Zuber, Johannes, Melichar, Heather, Mallette, Frédérick

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Role of Histone Methylation in the Regulation of Tumour Suppressor Networks by Neault, Mathieu

“…Cellular senescence is a tumour suppressor mechanism which prevents the proliferation of malignant cells. In normal cells, oncogenic stimuli induce a…”
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Catalytic synthesis of novel 4- C-glycosyl coumarins using a domino Heck reaction/lactonization process by Giguère, Denis, Patnam, Ramesh, Juarez-Ruiz, Juan M., Neault, Mathieu, Roy, René

“…A catalytic synthesis of novel 4-linked C-glycosyl coumarins was achieved using a domino Heck reaction/lactonization process. Methyl 3-glycosyl cinnamates were…”
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p16 INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells by Janelle, Valérie, Neault, Mathieu, Lebel, Marie-Ève, De Sousa, Dave Maurice, Boulet, Salix, Durrieu, Ludovic, Carli, Cédric, Muzac, Chloé, Lemieux, Sébastien, Labrecque, Nathalie, Melichar, Heather J, Mallette, Frédérick A, Delisle, Jean-Sébastien

“…T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant…”
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pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans: e94684 by Martin, Emmanuel, Harel, Sharon, Nkengfac, Bernard, Hamiche, Karim, Neault, Mathieu, Jenna, Sarah

“…Cell shape changes are crucial for metazoan development. During Caenorhabditis elegans embryogenesis, epidermal cell shape changes transform ovoid embryos into…”
Get full text