Search Results - "Neary, Roisin"

Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis by Watson, Chris J, Horgan, Stephen, Neary, Roisin, Glezeva, Nadezhda, Tea, Isaac, Corrigan, Niamh, McDonald, Ken, Ledwidge, Mark, Baugh, John

“…The development of heart failure is associated with changes in the size, shape, and structure of the heart that has a negative impact on cardiac function…”
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Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype by Robinson, Claire M, Neary, Roisin, Levendale, Ashleigh, Watson, Chris J, Baugh, John A

“…Pulmonary fibrosis is a debilitating and lethal disease with no effective treatment options. Understanding the pathological processes at play will direct the…”
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Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis by Neary, Roisin, Watson, Chris J, Baugh, John A

“…Fibrosis is a progressive and potentially fatal process that can occur in numerous organ systems. Characterised by the excessive deposition of extracellular…”
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The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance by Li, Lili, Howell, Katherine, Sands, Michelle, Banahan, Mark, Frohlich, Stephen, Rowan, Simon C, Neary, Roisín, Ryan, Donal, McLoughlin, Paul

“…Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional…”
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Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype by Watson, Chris J, Collier, Patrick, Tea, Isaac, Neary, Roisin, Watson, Jenny A, Robinson, Claire, Phelan, Dermot, Ledwidge, Mark T, McDonald, Kenneth M, McCann, Amanda, Sharaf, Osama, Baugh, John A

“…Ischemia caused by coronary artery disease and myocardial infarction leads to aberrant ventricular remodeling and cardiac fibrosis. This occurs partly through…”
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Inhibition of DNA methylation Reverses Aberrant Pathological Remodeling in the Setting of Pressure Overload by Russell‐Hallinan, Adam, Neary, Roisin, Watson, Chris, Baugh, John A.

“…Background Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome associated with significant morbidity and mortality. HFpEF is…”
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Repurposing From Oncology to Cardiology: Low-Dose 5-Azacytidine Attenuates Pathological Cardiac Remodeling in Response to Pressure Overload Injury by Russell-Hallinan, Adam, Neary, Roisin, Watson, Chris J, Baugh, John A

“…Recent evidence suggests that transcriptional reprogramming is involved in the pathogenesis of cardiac remodeling (cardiomyocyte hypertrophy and fibrosis) and…”
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Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis by Watson, Chris J, Phelan, Dermot, Xu, Maojia, Collier, Patrick, Neary, Roisin, Smolenski, Albert, Ledwidge, Mark, McDonald, Kenneth, Baugh, John

“…Mechanical overload of the heart is associated with excessive deposition of extracellular matrix proteins and the development of cardiac fibrosis. This can…”
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Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease by Horgan, Stephen J., Watson, Chris J., Glezeva, Nadia, Collier, Pat, Neary, Roisin, Tea, Isaac J., Corrigan, Niamh, Ledwidge, Mark, McDonald, Ken, Baugh, John A.

“…The potential for serum amyloid P-component (SAP) to prevent cardiac remodeling and identify worsening diastolic dysfunction (DD) was investigated. The…”
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Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-[beta] mediated fibrosis by Watson, Chris J, Phelan, Dermot, Xu, Maojia, Collier, Patrick, Neary, Roisin, Smolenski, Albert, Ledwidge, Mark, McDonald, Kenneth, Baugh, John

“…Background Mechanical overload of the heart is associated with excessive deposition of extracellular matrix proteins and the development of cardiac fibrosis…”
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The [alpha] and [DELTA] Isoforms of CREB1 Are Required to Maintain Normal Pulmonary Vascular Resistance by Li, Lili, Howell, Katherine, Sands, Michelle, Banahan, Mark, Frohlich, Stephen, Rowan, Simon C, Neary, Roisín, Ryan, Donal, McLoughlin, Paul

“…Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional…”
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