Search Results - "Neale, M. H."

Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window by Boyd, S R, Tan, D, Bunce, C, Gittos, A, Neale, M H, Hungerford, J L, Charnock-Jones, S, Cree, I A

“…Background: Improved local treatment of uveal melanoma makes it possible for many patients to retain the affected eye, but a proportion will develop secondary…”
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FLASH Is an Essential Component of Cajal Bodies by Barcaroli, D., Dinsdale, D., Neale, M. H., Bongiorno-Borbone, L., Ranalli, M., Munarriz, E., Sayan, A. E., McWilliam, J. M., Smith, T. M., Fava, E., Knight, R. A., Melino, G., De Laurenzi, V.

“…Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as…”
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Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growth by Boyd, S R, Tan, D S W, de Souza, L, Neale, M H, Myatt, N E, Alexander, R A, Robb, M, Hungerford, J L, Cree, I A

“…Background: Tumour microvascularity is a significant determinant of prognosis for a large number of different tumours, including uveal melanoma. The…”
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Combination chemotherapy for choroidal melanoma : ex vivo sensitivity to treosulfan with gemcitabine or cytosine arabinoside by NEALE, M. H, MYATT, N, CREE, I. A, KURBACHER, C. M, FOSS, A. J. E, HUNGERFORD, J. L, PLOWMAN, P. N

“…Treatment of choroidal melanoma by chemotherapy is usually unsuccessful, with response rates of less than 1% reported for dacarbazine (DTIC)-containing…”
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Comparison of the ex vivo chemosensitivity of uveal and cutaneous melanoma by Neale, M H, Myatt, N E, Khoury, G G, Weaver, P, Lamont, A, Hungerford, J L, Kurbacher, C M, Hall, P, Corrie, P G, Cree, I A

“…Cutaneous and uveal melanoma both have a poor prognosis and chemotherapy is usually unsuccessful. We have previously reported the activity of a number of…”
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Abnormalities of the transforming growth factor-beta pathway in ocular melanoma by Myatt, Nyree, Aristodemou, Petros, Neale, Michael H., Foss, Alex J. E., Hungerford, John L., Bhattacharya, Shomi, A Cree, Ian

“…The majority of ocular melanomas occur in the uveal tract. Chemotherapy is generally ineffective and large tumours requiring enucleation have a greater than…”
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Heterogeneity of chemosensitivity of metastatic cutaneous melanoma by Cree, I A, Neale, M H, Myatt, N E, de Takats, P G, Hall, P, Grant, J, Kurbacher, C M, Reinhold, U, Neuber, K, MacKie, R M, Chana, J, Weaver, P C, Khoury, G G, Sartori, C, Andreotti, P E

“…Advanced melanoma has a poor prognosis and chemotherapy provides little benefit for most patients. This may be related to heterogeneity of chemosensitivity as…”
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Use of an ATP-based chemosensitivity assay to design new combinations of high-concentration doxorubicin with other drugs for recurrent ovarian cancer by Di Nicolantonio, Federica, Neale, Michael H, Knight, Louise A, Lamont, Alan, Skailes, Geraldine E, Osborne, Richard J, Allerton, Rosanne, Kurbacher, Christian M, Cree, Ian A

“…Liposomal doxorubicin (Caelyx/Doxil) has been shown to be active in around 20% of recurrent ovarian cancers. As yet, there is little clinical data on…”
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Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma by Satherley, Kirsten, de Souza, Lavinia, H. Neale, Michael, A. Alexander, Robert, Myatt, Nyree, J. E. Foss, Alex, L. Hungerford, John, D. Hickson, Ian, A. Cree, Ian

“…Choroidal melanoma has a high mortality rate and responds poorly to existing chemotherapy, but unexpected ex vivo sensitivity of a subset of these tumours to…”
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The ex vivo effect of high concentrations of doxorubicin on recurrent ovarian carcinoma by Neale, Michael H, Lamont, Alan, Hindley, Andrew, Kurbacher, Christian M, Cree, Ian A

“…The cardiotoxicity of anthracyclines has largely prevented dose intensification, but the use of liposomal preparations (e.g. Caelyx/Doxil) allows much higher…”
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Ex vivo activity of XR5000 against solid tumors by Neale, Michael H, Charlton, Peter A, Cree, Ian A

“…Topoisomerases I and II unravel DNA during transcription, DNA replication and DNA repair. Inhibitors of both enzymes are important anticancer drugs, but only…”
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Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma by Sharma, Sanjay, Neale, Michael H, Di Nicolantonio, Federica, Knight, Louise A, Whitehouse, Pauline A, Mercer, Stuart J, Higgins, Bernard R, Lamont, Alan, Osborne, Richard, Hindley, Andrew C, Kurbacher, Christian M, Cree, Ian A

“…We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with…”
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Treosulfan and gemcitabine by Cree, Ian A, Neale, Michael H, Reinhold, Uwe, Kurbacher, Christian M

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"Complete Peerage" by BELLOT. BUTLER EDWARDS. GALBRAITH. NAMIER. NEALE, H. J. R. M. V. L

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