Search Results - "Neal L. Benowitz"

Pharmacology of Nicotine : Addiction, Smoking-Induced Disease, and Therapeutics by BENOWITZ, Neal L

“…Nicotine sustains tobacco addiction, a major cause of disability and premature death. Nicotine binds to nicotinic cholinergic receptors, facilitating…”
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Cardiovascular Toxicity of Nicotine: Implications for Electronic Cigarette Use by Benowitz, Neal L, Burbank, Andrea D

“…The cardiovascular safety of nicotine is an important question in the current debate on the benefits vs risks of electronic cigarettes and related public…”
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Neurobiology of Nicotine Addiction: Implications for Smoking Cessation Treatment by Benowitz, Neal L., MD

“…Abstract Nicotine sustains addictive tobacco use, which in turn causes much premature disability and death. The essence of drug addiction is loss of control of…”
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Biochemical Verification of Tobacco Use and Abstinence: 2019 Update by Benowitz, Neal L, Bernert, John T, Foulds, Jonathan, Hecht, Stephen S, Jacob, Peyton, Jarvis, Martin J, Joseph, Anne, Oncken, Cheryl, Piper, Megan E

“…Abstract Background The changing prevalence and patterns of tobacco use, the advent of novel nicotine delivery devices, and the development of new biomarkers…”
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Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial by Anthenelli, Robert M, Prof, Benowitz, Neal L, Prof, West, Robert, Prof, St Aubin, Lisa, DVM, McRae, Thomas, MD, Lawrence, David, PhD, Ascher, John, MD, Russ, Cristina, MD, Krishen, Alok, MS, Evins, A Eden, Prof

“…Summary Background Substantial concerns have been raised about the neuropsychiatric safety of the smoking cessation medications varenicline and bupropion…”
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The Past, Present, and Future of Nicotine Addiction Therapy by Prochaska, Judith J, Benowitz, Neal L

“…The tobacco addiction treatment field is progressing through innovations in medication development, a focus on precision medicine, and application of new…”
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The Regulatory Challenge of Electronic Cigarettes by Benowitz, Neal L, Goniewicz, Maciej L

“…Benowitz and Goniewicz talk about electronic cigarettes, which heat a nicotine solution to generate vapor that is inhaled, without the combustion of tobacco…”
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Nicotine chemistry, metabolism, kinetics and biomarkers by Benowitz, Neal L, Hukkanen, Janne, Jacob, 3rd, Peyton

“…Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a pharmacological aid to smoking cessation. The absorption, distribution…”
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Characterization of Nicotine Salts in 23 Electronic Cigarette Refill Liquids by Harvanko, Arit M, Havel, Christopher M, Jacob, Peyton, Benowitz, Neal L

“…Abstract Introduction Many electronic cigarette manufacturers have begun offering liquids containing “nicotine salts,” which are formed when an acid is mixed…”
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Current advances in research in treatment and recovery: Nicotine addiction by Prochaska, Judith J, Benowitz, Neal L

“…The health harms of combusted tobacco use are undeniable. With market and regulatory pressures to reduce the harms of nicotine delivery by combustion, the…”
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Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes by St.Helen, Gideon, Havel, Christopher, Dempsey, Delia A., Jacob III, Peyton, Benowitz, Neal L.

“…Aims To measure the systemic retention of nicotine, propylene glycol (PG) and vegetable glycerin (VG) in electronic cigarette (e‐cigarette) users, and assess…”
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E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke by Martin, Elizabeth M, Clapp, Phillip W, Rebuli, Meghan E, Pawlak, Erica A, Glista-Baker, Ellen, Benowitz, Neal L, Fry, Rebecca C, Jaspers, Ilona

“…Exposure to cigarette smoke is known to result in impaired host defense responses and immune suppressive effects. However, the effects of new and emerging…”
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Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients by Panzer, Ariane R, Lynch, Susan V, Langelier, Chaz, Christie, Jason D, McCauley, Kathryn, Nelson, Mary, Cheung, Christopher K, Benowitz, Neal L, Cohen, Mitchell J, Calfee, Carolyn S

“…Cigarette smoking is associated with increased risk of acute respiratory distress syndrome (ARDS) in patients after severe trauma; however, the mechanisms…”
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Metabolism and Disposition Kinetics of Nicotine by Hukkanen, Janne, Jacob, 3rd, Peyton, Benowitz, Neal L

“…Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a…”
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Determination of the nicotine metabolites cotinine and trans-3′-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography–tandem mass spectrometry: Biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity by Jacob, Peyton, Yu, Lisa, Duan, Minjiang, Ramos, Lita, Yturralde, Olivia, Benowitz, Neal L.

“…The nicotine metabolite cotinine is widely used to assess the extent of tobacco use in smokers, and secondhand smoke exposure in non-smokers. The ratio of…”
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Ubiquitous atmospheric contamination by tobacco smoke: Nicotine and a new marker for tobacco smoke-derived particulate matter, nicotelline by Aquilina, Noel J., Havel, Christopher M., Cheung, Polly, Harrison, Roy M., Ho, Kin-Fai, Benowitz, Neal L., Jacob III, Peyton

“…[Display omitted] •Nicotelline is ubiquitous and easily detected in airborne PM.•Particulate nicotelline is directly proportional to total (particle+gas phase)…”
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Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial by Lerman, Caryn, Prof, Schnoll, Robert A, PhD, Hawk, Larry W, Prof, Cinciripini, Paul, Prof, George, Tony P, Prof, Wileyto, E Paul, PhD, Swan, Gary E, Prof, Benowitz, Neal l, Prof, Heitjan, Daniel F, Prof, Tyndale, Rachel F, Prof

“…Summary Background Substantial variability exists in therapeutic response and adverse effects with pharmacotherapies for tobacco dependence. Biomarkers to…”
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Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome by Calfee, Carolyn S, Matthay, Michael A, Kangelaris, Kirsten N, Siew, Edward D, Janz, David R, Bernard, Gordon R, May, Addison K, Jacob, Peyton, Havel, Christopher, Benowitz, Neal L, Ware, Lorraine B

“…OBJECTIVE:The association between cigarette smoke exposure and the acute respiratory distress syndrome in patients with the most common acute respiratory…”
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Transferability of Ancestry‐Specific and Cross‐Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations by El‐Boraie, Ahmed, Chenoweth, Meghan J., Pouget, Jennie G., Benowitz, Neal L., Fukunaga, Koya, Mushiroda, Taisei, Kubo, Michiaki, Nollen, Nicole L., Sanderson Cox, Lisa, Lerman, Caryn, Knight, Jo, Tyndale, Rachel F.

“…The Nicotine Metabolite Ratio (NMR; 3‐hydroxycotinine/cotinine), a highly heritable index of nicotine metabolic inactivation by the CYP2A6 enzyme, is…”
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Nicotine Addiction by Benowitz, Neal L

“…This review gives an account of the cigarette as a highly efficient nicotine delivery system. It explains how nicotine induces pleasure, reduces stress and…”
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