Search Results - "Neal, GE"

Insecticidal and vertebrate toxicity associated with ethnobotanicals used as post-harvest protectants in Ghana by Belmain, S.R., Neal, GE, Ray, D.E., Golob, P.

“…Six plant species ( Cassia sophera, Chamaecrista nigricans, Mitragyna inermis, Ocimum americanum, Securidaca longepedunculata and Synedrella nodiflora)…”
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Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1 by Sherratt, P J, Manson, M M, Thomson, A M, Hissink, E A, Neal, G E, van Bladeren, P J, Green, T, Hayes, J D

“…A characteristic feature of the class Theta glutathione S-transferase (GST) T1-1 is its ability to activate dichloromethane and dibromoethane by catalysing the…”
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Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: Mechanisms of inducible resistance to aflatoxin B 1 by Hayes, John D, Pulford, David J, Ellis, Elizabeth M, McLeod, Ronald, James, Roger F.L, Seidegård, Janeric, Mosialou, Erifili, Jernström, Bengt, Neal, Gordon E

“…The rat can be protected against aflatoxin B 1 (AFB 1) hepatocarcinogenesis by being fed on a diet containing the synthetic antioxidant ethoxyquin. Evidence…”
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Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin by Hayes, J D, Judah, D J, Neal, G E

“…Fischer 344 rats readily develop liver cancer when exposed to aflatoxin B1 (AFB1) but dietary administration of the antioxidant ethoxyquin (EQ) provides…”
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Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1 by Hayes, J D, Pulford, D J, Ellis, E M, McLeod, R, James, R F, Seidegård, J, Mosialou, E, Jernström, B, Neal, G E

“…The rat can be protected against aflatoxin B1 (AFB1) hepatocarcinogenesis by being fed on a diet containing the synthetic antioxidant ethoxyquin. Evidence…”
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Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver by FORRESTER, L. M, NEAL, G. E, JUDAH, D. J, GLANCEY, M. J, WOLF, C. R

“…Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B1…”
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Sequential study of the chronic nephrotoxicity induced by dietary administration of ethoxyquin in Fischer 344 rats by Hard, G C, Neal, G E

“…Groups of 3-week-old male and female Fischer 344 rats were administered 0.5% ethoxyquin-containing diet for varying periods of time, ranging from 4 weeks up to…”
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Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress by Hayes, J D, Ellis, E M, Neal, G E, Harrison, D J, Manson, M M

“…Cancer chemopreventive agents can act by inhibiting either the acquisition of mutations or the neoplastic processes that occur subsequent to mutagenesis…”
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Genetic implications in the metabolism and toxicity of mycotoxins by Neal, G.E.

“…In common with many xenobiotics, metabolic activation and detoxification play crucial roles in the determination of a toxic response of animal species,…”
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Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide by Hayes, J.D, Judah, D.J, McLellan, L.I, Kerr, L.A, Peacock, S.D, Neal, G.E

“…A purification scheme has been devised for two ethoxyquin-inducible Alpha-class glutathione S-transferases (GSTs) which possess at least 25-fold greater…”
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Differences in ethoxyquin nephrotoxicity between male and female F344 rats by Neal, G.E, Judah, D.J, Hard, G.G, Ito, N

“…Dose–response studies have shown a sharp threshold for the renal papillary toxic effect in male rats between 0.25% and 0.5% ethoxyquin (Eto) in the diet over 6…”
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Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide by HAYES, J. D, JUDAH, D. J, NEAL, G. E, NGUYEN, T

“…Resistance to the carcinogenic effects of aflatoxin B1 (AFB1) in the mouse is due to the constitutive expression of an Alpha-class glutathione S-transferase…”
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Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1 by Hayes, J D, Judah, D J, McLellan, L I, Neal, G E

“…The harmful effects of Aflatoxin B1 (AFB1) are a consequence of it being metabolized to AFB1-8,9-epoxide, a compound that serves as an alkylating agent and…”
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Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors by ELLIS, E. M, JUDAH, D. J, NEAL, G. E, O'CONNOR, T, HAYES, J. D

“…Feeding rats on diets containing the synthetic antioxidants ethoxyquin, butylated hydroxyanisole, and oltipraz results in 15-, 9-, and 6-fold increases,…”
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Metabolism and toxicity of aflatoxins M sub(1) and B sub(1) in human-derived in vitro systems by Neal, GE, Eaton, D L, Judah, D J, Verma, A

“…Aflatoxin M sub(1) (AFM sub(1)) is the principal hydroxylated aflatoxin metabolite present in the milk of dairy cows fed a diet contaminated with aflatoxin B…”
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In vitro activation of the human Harvey-ras proto-oncogene by aflatoxin B sub(1) by Riley, J, Mandel, H G, Sinha, S, Judah, D J, Neal, GE

“…Activation of ras proto-oncogenes occurs frequently in vivo in chemically induced rodent tumours, including rat hepatomas induced by aflatoxin B sub(1). This…”
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Mutations associated with in vivo aflatoxin B sub(1)-induced carcinogenesis need not be present in the in vitro transformations by this toxin by Stanley, LA, Mandel, H G, Riley, J, Sinha, S, Higginson, F M, Judah, D J, Neal, GE

“…Ingestion of aflatoxin B sub(1) is implicated in the high incidence of human liver cancers in several developing countries. An association has been detected…”
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Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes by Mayol, X, Neal, G E, Davies, R, Romero, A, Domingo, J

“…Hepatocyte proliferation was analyzed in vivo during the time course of continuous administration to rats of the liver tumor promoter ethinyl estradiol (EE) at…”
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Chemoprevention of aflatoxin B sub(1)-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers by Manson, M M, Hudson, E A, Ball, HWL, Barrett, M C, Clark, H L, Judah, D J, Verschoyle, R D, Neal, GE

“…Indole-3-carbinol (I3C) was examined for its ability to inhibit aflatoxin B sub(1) (AFB sub(1))-induced hepatocarcinogenesis in male Fischer rats when…”
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Mechanism of action of dietary chemoprotective agents in rat liver: Induction of phase I and II drug metabolizing enzymes and aflatoxin B sub(1) metabolism by Manson, M M, Ball, HWL, Barrett, M C, Clark, H L, Judah, D J, Williamson, G, Neal, GE

“…A range of potential chemoprotective agents, most of them natural dietary constituents, has been examined for ability to modulate both phase I (cytochrome P450…”
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