Search Results - "Neal, David E"

The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man by Sharma, Naomi L., Massie, Charlie E., Ramos-Montoya, Antonio, Zecchini, Vincent, Scott, Helen E., Lamb, Alastair D., MacArthur, Stewart, Stark, Rory, Warren, Anne Y., Mills, Ian G., Neal, David E.

“…The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We present a comprehensive…”
Get full text

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets by Wedge, David C., Gundem, Gunes, Mitchell, Thomas, Woodcock, Dan J., Martincorena, Inigo, Ghori, Mohammed, Zamora, Jorge, Butler, Adam, Whitaker, Hayley, Kote-Jarai, Zsofia, Alexandrov, Ludmil B., Van Loo, Peter, Massie, Charlie E., Dentro, Stefan, Warren, Anne Y., Verrill, Clare, Berney, Dan M., Dennis, Nening, Merson, Sue, Hawkins, Steve, Howat, William, Lu, Yong-Jie, Lambert, Adam, Kay, Jonathan, Kremeyer, Barbara, Karaszi, Katalin, Luxton, Hayley, Camacho, Niedzica, Marsden, Luke, Edwards, Sandra, Matthews, Lucy, Bo, Valeria, Leongamornlert, Daniel, McLaren, Stuart, Ng, Anthony, Yu, Yongwei, Zhang, Hongwei, Dadaev, Tokhir, Thomas, Sarah, Easton, Douglas F., Ahmed, Mahbubl, Bancroft, Elizabeth, Fisher, Cyril, Livni, Naomi, Nicol, David, Tavaré, Simon, Gill, Pelvender, Greenman, Christopher, Khoo, Vincent, Van As, Nicholas, Kumar, Pardeep, Ogden, Christopher, Cahill, Declan, Thompson, Alan, Mayer, Erik, Rowe, Edward, Dudderidge, Tim, Gnanapragasam, Vincent, Shah, Nimish C., Raine, Keiran, Jones, David, Menzies, Andrew, Stebbings, Lucy, Teague, Jon, Hazell, Steven, Corbishley, Cathy, de Bono, Johann, Attard, Gerhardt, Isaacs, William, Visakorpi, Tapio, Fraser, Michael, Boutros, Paul C., Bristow, Robert G., Workman, Paul, Sander, Chris, Hamdy, Freddie C., Futreal, Andrew, McDermott, Ultan, Al-Lazikani, Bissan, Lynch, Andrew G., Bova, G. Steven, Foster, Christopher S., Brewer, Daniel S., Neal, David E., Cooper, Colin S., Eeles, Rosalind A.

“…Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the…”
Get full text

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis by Massie, Charles E, Lynch, Andy, Ramos-Montoya, Antonio, Boren, Joan, Stark, Rory, Fazli, Ladan, Warren, Anne, Scott, Helen, Madhu, Basetti, Sharma, Naomi, Bon, Helene, Zecchini, Vinny, Smith, Donna-Michelle, DeNicola, Gina M, Mathews, Nik, Osborne, Michelle, Hadfield, James, MacArthur, Stewart, Adryan, Boris, Lyons, Scott K, Brindle, Kevin M, Griffiths, John, Gleave, Martin E, Rennie, Paul S, Neal, David E, Mills, Ian G

“…The androgen receptor (AR) is a key regulator of prostate growth and the principal drug target for the treatment of prostate cancer. Previous studies have…”
Get full text

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers by Hayami, Shinya, Kelly, John D., Cho, Hyun‐Soo, Yoshimatsu, Masanori, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Neal, David E., Yamaue, Hiroki, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…A number of histone demethylases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human disease like…”
Get full text

Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial by Lane, J Athene, PhD, Donovan, Jenny L, Prof, Davis, Michael, MSc, Walsh, Eleanor, MSc, Dedman, Daniel, MSc, Down, Liz, BSc, Turner, Emma L, PhD, Mason, Malcolm D, Prof, Metcalfe, Chris, PhD, Peters, Tim J, Prof, Martin, Richard M, PhD, Neal, David E, Prof, Hamdy, Freddie C, Prof

“…Summary Background Prostate cancer is a major public health problem with considerable uncertainties about the effectiveness of population screening and…”
Get full text

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers by Yoshimatsu, Masanori, Toyokawa, Gouji, Hayami, Shinya, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Kelly, John D., Neal, David E., Maehara, Yoshihiko, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…Protein arginine methylation is a novel post‐translational modification regulating a diversity of cellular processes, including histone functions, but the…”
Get full text

Estrogen receptor beta in prostate cancer: friend or foe? by Nelson, Adam W, Tilley, Wayne D, Neal, David E, Carroll, Jason S

“…Prostate cancer is the commonest, non-cutaneous cancer in men. At present, there is no cure for the advanced, castration-resistant form of the disease…”
Get full text

Gene regulatory mechanisms underpinning prostate cancer susceptibility by Whitington, Thomas, Gao, Ping, Song, Wei, Ross-Adams, Helen, Lamb, Alastair D, Yang, Yuehong, Svezia, Ilaria, Klevebring, Daniel, Mills, Ian G, Karlsson, Robert, Halim, Silvia, Dunning, Mark J, Egevad, Lars, Warren, Anne Y, Neal, David E, Grönberg, Henrik, Lindberg, Johan, Wei, Gong-Hong, Wiklund, Fredrik

“…Thomas Whitington and colleagues present a detailed characterization of gene regulatory mechanisms underlying prostate cancer susceptibility. Their analysis…”
Get full text

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17 by Willems, Sofie H, Tape, Christopher J, Stanley, Peter L, Taylor, Neil A, Mills, Ian G, Neal, David E, McCafferty, John, Murphy, Gillian

“…ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms of…”
Get more information

Structural basis for the nuclear import of the human androgen receptor by Cutress, Mark L, Whitaker, Hayley C, Mills, Ian G, Stewart, Murray, Neal, David E

“…Ligand-dependent nuclear import is crucial for the function of the androgen receptor (AR) in both health and disease. The unliganded AR is retained in the…”
Get full text

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation by Cho, Hyun-Soo, Hayami, Shinya, Toyokawa, Gouji, Maejima, Kazuhiro, Yamane, Yuka, Suzuki, Takehiro, Dohmae, Naoshi, Kogure, Masaharu, Kang, Daechun, Neal, David E, Ponder, Bruce A.J, Yamaue, Hiroki, Nakamura, Yusuke, Hamamoto, Ryuji

“…Abstract It is well known that RB functions are regulated by posttranslational modifications such as phosphorylation and acetylation, but the significance of…”
Get full text

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway by Hayami, Shinya, Yoshimatsu, Masanori, Veerakumarasivam, Abhimanyu, Unoki, Motoko, Iwai, Yukiko, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Yamaue, Hiroki, Ponder, Bruce A J, Nakamura, Yusuke, Hamamoto, Ryuji

“…Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain…”
Get full text

CD133, a novel marker for human prostatic epithelial stem cells by Richardson, Gavin D, Robson, Craig N, Lang, Shona H, Neal, David E, Maitland, Norman J, Collins, Anne T

“…Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate…”
Get full text

Independence of HIF1a and androgen signaling pathways in prostate cancer by Tran, Maxine G B, Bibby, Becky A S, Yang, Lingjian, Lo, Franklin, Warren, Anne Y, Shukla, Deepa, Osborne, Michelle, Hadfield, James, Carroll, Thomas, Stark, Rory, Scott, Helen, Ramos-Montoya, Antonio, Massie, Charlie, Maxwell, Patrick, West, Catharine M L, Mills, Ian G, Neal, David E

“…Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen…”
Get full text

Psychological Impact of Prostate Biopsy: Physical Symptoms, Anxiety, and Depression by WADE, Julia, ROSARIO, Derek J, HAMDY, Freddie C, DONOVAN, Jenny L, MACEFIELD, Rhiannon C, AVERY, Kerry N. L, ELIZABETH SALTER, C, LOUISE GOODWIN, M, BLAZEBY, Jane M, ATHENE LANE, J, METCALFE, Chris, NEAL, David E

“…To investigate the psychological impact of prostate biopsy, including relationships between physical biopsy-related symptoms and anxiety and depression. A…”
Get full text

Impact of PSA testing on secondary care costs in England and Wales: estimates from the Cluster randomised triAl of PSA testing for Prostate cancer (CAP) by Thorn, Joanna C, Turner, Emma L, Walsh, Eleanor I, Donovan, Jenny L, Neal, David E, Hamdy, Freddie C, Martin, Richard M, Noble, Sian M

“…Screening men for prostate cancer using prostate-specific antigen (PSA) testing remains controversial. We aimed to estimate the likely budgetary impact on…”
Get full text

Engrailed-2 (EN2): A Tumor Specific Urinary Biomarker for the Early Diagnosis of Prostate Cancer by MORGAN, Richard, BOXALL, Angela, ANNELS, Nicola, MICHAEL, Agnieszka, PANDHA, Hardev, BHATT, Aagna, BAILEY, Michael, HINDLEY, Richard, LANGLEY, Stephen, WHITAKER, Hayley C, NEAL, David E, ISMAIL, Mohammed, WHITAKER, Hamish

“…Prostate cancer (PC) is the second most common cause of cancer related death in men. A number of key limitations with prostate specific antigen (PSA),…”
Get full text

Genome-wide association study identifies new prostate cancer susceptibility loci by Schumacher, Fredrick R., Berndt, Sonja I., Siddiq, Afshan, Jacobs, Kevin B., Wang, Zhaoming, Lindstrom, Sara, Stevens, Victoria L., Chen, Constance, Mondul, Alison M., Travis, Ruth C., Stram, Daniel O., Eeles, Rosalind A., Easton, Douglas F., Giles, Graham, Hopper, John L., Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Muir, Kenneth, Al Olama, Ali Amin, Kote-Jarai, Zsofia, Guy, Michelle, Severi, Gianluca, Grönberg, Henrik, Isaacs, William B., Karlsson, Robert, Wiklund, Fredrik, Xu, Jianfeng, Allen, Naomi E., Andriole, Gerald L., Barricarte, Aurelio, Boeing, Heiner, Bas Bueno-de-Mesquita, H., Crawford, E. David, Diver, W. Ryan, Gonzalez, Carlos A., Gaziano, J. Michael, Giovannucci, Edward L., Johansson, Mattias, Le Marchand, Loic, Ma, Jing, Sieri, Sabina, Stattin, Pär, Stampfer, Meir J., Tjonneland, Anne, Vineis, Paolo, Virtamo, Jarmo, Vogel, Ulla, Weinstein, Stephanie J., Yeager, Meredith, Thun, Michael J., Kolonel, Laurence N., Henderson, Brian E., Albanes, Demetrius, Hayes, Richard B., Spencer Feigelson, Heather, Riboli, Elio, Hunter, David J., Chanock, Stephen J., Haiman, Christopher A., Kraft, Peter

“…Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet…”
Get full text

Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer by Bon, Hélène, Wadhwa, Karan, Schreiner, Alexander, Osborne, Michelle, Carroll, Thomas, Ramos-Montoya, Antonio, Ross-Adams, Helen, Visser, Matthieu, Hoffmann, Ralf, Ahmed, Ahmed Ashour, Neal, David E, Mills, Ian G

“…Salt-inducible kinase 2 (SIK2) is a multifunctional kinase of the AMPK family that plays a role in CREB1-mediated gene transcription and was recently reported…”
Get full text

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer by Toyokawa, Gouji, Masuda, Ken, Daigo, Yataro, Cho, Hyun-Soo, Yoshimatsu, Masanori, Takawa, Masashi, Hayami, Shinya, Maejima, Kazuhiro, Chino, Makoto, Field, Helen I, Neal, David E, Tsuchiya, Eiju, Ponder, Bruce A J, Maehara, Yoshihiko, Nakamura, Yusuke, Hamamoto, Ryuji

“…The research emphasis in anti-cancer drug discovery has always been to search for a drug with the greatest antitumor potential but fewest side effects. This…”
Get full text