Search Results - "Némati, Fariba"

High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer by Grosselin, Kevin, Durand, Adeline, Marsolier, Justine, Poitou, Adeline, Marangoni, Elisabetta, Nemati, Fariba, Dahmani, Ahmed, Lameiras, Sonia, Reyal, Fabien, Frenoy, Olivia, Pousse, Yannick, Reichen, Marcel, Woolfe, Adam, Brenan, Colin, Griffiths, Andrew D., Vallot, Céline, Gérard, Annabelle

“…Modulation of chromatin structure via histone modification is a major epigenetic mechanism and regulator of gene expression. However, the contribution of…”
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PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers by Gentric, Géraldine, Kieffer, Yann, Mieulet, Virginie, Goundiam, Oumou, Bonneau, Claire, Nemati, Fariba, Hurbain, Ilse, Raposo, Graca, Popova, Tatiana, Stern, Marc-Henri, Lallemand-Breitenbach, Valérie, Müller, Sebastian, Cañeque, Tatiana, Rodriguez, Raphaël, Vincent-Salomon, Anne, de Thé, Hugues, Rossignol, Rodrigue, Mechta-Grigoriou, Fatima

“…High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we unravel an unanticipated metabolic heterogeneity in HGSOC. By combining…”
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PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance by Montaudon, Elodie, Nikitorowicz-Buniak, Joanna, Sourd, Laura, Morisset, Ludivine, El Botty, Rania, Huguet, Léa, Dahmani, Ahmed, Painsec, Pierre, Nemati, Fariba, Vacher, Sophie, Chemlali, Walid, Masliah-Planchon, Julien, Château-Joubert, Sophie, Rega, Camilla, Leal, Mariana Ferreira, Simigdala, Nikiana, Pancholi, Sunil, Ribas, Ricardo, Nicolas, André, Meseure, Didier, Vincent-Salomon, Anne, Reyes, Cécile, Rapinat, Audrey, Gentien, David, Larcher, Thibaut, Bohec, Mylène, Baulande, Sylvain, Bernard, Virginie, Decaudin, Didier, Coussy, Florence, Le Romancer, Muriel, Dutertre, Guillaume, Tariq, Zakia, Cottu, Paul, Driouch, Keltouma, Bièche, Ivan, Martin, Lesley-Ann, Marangoni, Elisabetta

“…A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC) develop resistance to endocrine treatments (ET) and relapse with…”
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Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts by Némati, Fariba, de Montrion, Catherine, Lang, Guillaume, Kraus-Berthier, Laurence, Carita, Guillaume, Sastre-Garau, Xavier, Berniard, Aurélie, Vallerand, David, Geneste, Olivier, de Plater, Ludmilla, Pierré, Alain, Lockhart, Brian, Desjardins, Laurence, Piperno-Neumann, Sophie, Depil, Stéphane, Decaudin, Didier

“…Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is…”
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Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer by Mieulet, Virginie, Garnier, Camille, Kieffer, Yann, Guilbert, Thomas, Nemati, Fariba, Marangoni, Elisabetta, Renault, Gilles, Chamming’s, Foucauld, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima

“…Women diagnosed with high-grade serous ovarian cancers (HGSOC) are still likely to exhibit a bad prognosis, particularly when suffering from HGSOC of the…”
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Ferrocifen stealth LNCs and conventional chemotherapy: A promising combination against multidrug-resistant ovarian adenocarcinoma by Idlas, Pierre, Ladaycia, Abdallah, Némati, Fariba, Lepeltier, Elise, Pigeon, Pascal, Jaouen, Gerard, Decaudin, Didier, Passirani, Catherine

“…[Display omitted] Ovarian cancer is one of the deadliest epithelial malignancies in women, owing to the multidrug resistance that restricts the success of…”
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BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers by Coussy, Florence, El-Botty, Rania, Château-Joubert, Sophie, Dahmani, Ahmed, Montaudon, Elodie, Leboucher, Sophie, Morisset, Ludivine, Painsec, Pierre, Sourd, Laura, Huguet, Léa, Nemati, Fariba, Servely, Jean-Luc, Larcher, Thibaut, Vacher, Sophie, Briaux, Adrien, Reyes, Cécile, La Rosa, Philippe, Lucotte, Georges, Popova, Tatiana, Foidart, Pierre, Sounni, Nor Eddine, Noel, Agnès, Decaudin, Didier, Fuhrmann, Laetitia, Salomon, Anne, Reyal, Fabien, Mueller, Christopher, Ter Brugge, Petra, Jonkers, Jos, Poupon, Marie-France, Stern, Marc-Henri, Bièche, Ivan, Pommier, Yves, Marangoni, Elisabetta

“…Topoisomerase I (TOP1) inhibitors trap TOP1 cleavage complexes resulting in DNA double-strand breaks (DSBs) during replication, which are repaired by…”
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Polo-like Kinase 1: A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer by MAIRE, Virginie, NEMATI, Fariba, GENTIEN, David, DUMONT, Aurélie, BARILLOT, Emmanuel, MARANGONI, Elisabetta, DECAUDIN, Didier, ROMAN-ROMAN, Sergio, PIERRE, Alain, CRUZALEGUI, Francisco, DEPIL, Stéphane, TUCKER, Gordon C, RICHARDSON, Marion, DUBOIS, Thierry, VINCENT-SALOMON, Anne, TESSON, Bruno, RIGAILL, Guillem, GRAVIER, Eléonore, MARTY-PROUVOST, Bérengère, DE KONING, Leanne, LANG, Guillaume

“…Breast cancers are composed of molecularly distinct subtypes with different clinical outcomes and responses to therapy. To discover potential therapeutic…”
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Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes by van Essen, T Huibertus, van Pelt, Sake I, Bronkhorst, Inge H G, Versluis, Mieke, Némati, Fariba, Laurent, Cécile, Luyten, Gregorius P M, van Hall, Thorbald, van den Elsen, Peter J, van der Velden, Pieter A, Decaudin, Didier, Jager, Martine J

“…Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and increased human leukocyte antigen (HLA) expression, carry an…”
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Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer by JULIEN, Sylvia, MERINO-TRIGO, Ana, WEISWALD, Louis-Bastien, LANTUAS, Denis, MORGAND, Loïc, PHAM, Emmanuel, GONIN, Patrick, DANGLES-MARIE, Virginie, JOB, Bastien, DESSEN, Philippe, BRUNO, Alain, PIERRE, Alain, LACROIX, Ludovic, DE THE, Hugues, SOLIMAN, Hany, NUNES, Manoel, LARDIER, Guillaume, CALVET, Loreley, DEMERS, Brigitte, PREVOST, Gregoire, VRIGNAUD, Patricia, ROMAN-ROMAN, Sergio, DUCHAMP, Olivier, POCARD, Marc, BERTHET, Cyril, GOERE, Diane, MARIANI, Pascale, LANDRON, Sophie, BIGOT, Ludovic, NEMATI, Fariba, DARTIGUES, Peggy

“…Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and advanced preclinical models. Our consortium joins efforts…”
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Splicing Patterns in SF3B1 -Mutated Uveal Melanoma Generate Shared Immunogenic Tumor-Specific Neoepitopes by Bigot, Jeremy, Lalanne, Ana I, Lucibello, Francesca, Gueguen, Paul, Houy, Alexandre, Dayot, Stephane, Ganier, Olivier, Gilet, Jules, Tosello, Jimena, Nemati, Fariba, Pierron, Gaelle, Waterfall, Joshua J, Barnhill, Raymond, Gardrat, Sophie, Piperno-Neumann, Sophie, Popova, Tatiana, Masson, Vanessa, Loew, Damarys, Mariani, Pascale, Cassoux, Nathalie, Amigorena, Sebastian, Rodrigues, Manuel, Alsafadi, Samar, Stern, Marc-Henri, Lantz, Olivier

“…Disruption of splicing patterns due to mutations of genes coding splicing factors in tumors represents a potential source of tumor neoantigens, which would be…”
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High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-XL inhibition against Ewing sarcoma by Grissenberger, Sarah, Sturtzel, Caterina, Wenninger-Weinzierl, Andrea, Radic-Sarikas, Branka, Scheuringer, Eva, Bierbaumer, Lisa, Etienne, Vesnie, Némati, Fariba, Pascoal, Susana, Tötzl, Marcus, Tomazou, Eleni M., Metzelder, Martin, Putz, Eva M., Decaudin, Didier, Delattre, Olivier, Surdez, Didier, Kovar, Heinrich, Halbritter, Florian, Distel, Martin

“…Ewing sarcoma is a pediatric bone and soft tissue cancer with an urgent need for new therapies to improve disease outcome. To identify effective drugs,…”
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Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor by Ducarouge, Benjamin, Redavid, Anna-Rita, Victoor, Camille, Chira, Ruxanda, Fonseca, Aurélien, Hervieu, Maëva, Bergé, Roméo, Lengrand, Justine, Vieugué, Pauline, Neves, David, Goddard, Isabelle, Richaud, Mathieu, Laval, Pierre-Alexandre, Rama, Nicolas, Goldschneider, David, Paradisi, Andrea, Gourdin, Nicolas, Chabaud, Sylvie, Treilleux, Isabelle, Gadot, Nicolas, Ray-Coquard, Isabelle, Depil, Stéphane, Decaudin, Didier, Némati, Fariba, Marangoni, Elisabetta, Mery-Lamarche, Eliane, Génestie, Catherine, Tabone-Eglinger, Séverine, Devouassoux-Shisheboran, Mojgan, Moore, Kathryn J., Gibert, Benjamin, Mehlen, Patrick, Bernet, Agnes

“…Drug resistance and cancer relapse represent significant therapeutic challenges after chemotherapy or immunotherapy, and a major limiting factor for long-term…”
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Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors by Némati, Fariba, Sastre-Garau, Xavier, Laurent, Cécile, Couturier, Jérôme, Mariani, Pascale, Desjardins, Laurence, Piperno-Neumann, Sophie, Lantz, Olivier, Asselain, Bernard, Plancher, Corine, Robert, Delphine, Péguillet, Isabelle, Donnadieu, Marie-Hélène, Dahmani, Ahmed, Bessard, Marie-Andrée, Gentien, David, Reyes, Cécile, Saule, Simon, Barillot, Emmanuel, Roman-Roman, Sergio, Decaudin, Didier

“…Uveal melanoma is the most common primary intraocular malignant tumor in adults and is defined by a poor natural outcome, as 50% of patients die from…”
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Imatinib Mesylate Reduces Rituximab-Induced Tumor Growth Inhibition In Vivo on EBV-Associated Human B-Cell Lymphoma by Némati, Fariba, Mathiot, Claire, Grandjean, Isabelle, Lantz, Olivier, Bordier, Vincent, Dewulf, Sébastien, Ekue, Richard, Di Santo, James P., Poupon, Marie-France, Decaudin, Didier

“…We previously reported an increase of tumor growth inhibition following chemotherapy combined with concomitantly administration of imatinib mesylate [Decaudin…”
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Experimental and Numerical Analyses of Perforated Corrugated Steel Shear Walls by Nouri, Gholamreza, Rayegani, Arash, Nemati, Fariba, Eftekhar, Gholam Hossein

“…This study presents an evaluation of the seismic performance of corrugated steel shear walls (CSSWs) with openings. Cyclic experimental tests were conducted on…”
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Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers by Vinet, Mathilde, Suresh, Samyuktha, Maire, Virginie, Monchecourt, Clarisse, Némati, Fariba, Lesage, Laetitia, Pierre, Fabienne, Ye, Mengliang, Lescure, Auriane, Brisson, Amélie, Meseure, Didier, Nicolas, André, Rigaill, Guillem, Marangoni, Elisabetta, Del Nery, Elaine, Roman‐Roman, Sergio, Dubois, Thierry

“…TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted therapy yet exists. Protein…”
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The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival by Dewaele, Shanna, Delhaye, Louis, De Paepe, Boel, de Bony, Eric James, De Wilde, Jilke, Vanderheyden, Katrien, Anckaert, Jasper, Yigit, Nurten, Nuytens, Justine, Vanden Eynde, Eveline, Smet, Joél, Verschoore, Maxime, Nemati, Fariba, Decaudin, Didier, Rodrigues, Manuel, Zhao, Peihua, Jochemsen, Aart, Leucci, Eleonora, Vandesompele, Jo, Van Dorpe, Jo, Marine, Jean-Christophe, Van Coster, Rudy, Eyckerman, Sven, Mestdagh, Pieter

“…Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets…”
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Identification of a human estrogen receptor α tetrapeptidic fragment with dual antiproliferative and anti-nociceptive action by Jouffre, Baptiste, Acramel, Alexandre, Belnou, Mathilde, Santolla, Maria Francesca, Talia, Marianna, Lappano, Rosamaria, Nemati, Fariba, Decaudin, Didier, Khemtemourian, Lucie, Liu, Wang-Qing, Maggiolini, Marcello, Eschalier, Alain, Mallet, Christophe, Jacquot, Yves

“…The synthetic peptide ERα17p (sequence: PLMIKRSKKNSLALSLT), which corresponds to the 295–311 region of the human estrogen receptor α (ERα), induces apoptosis…”
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Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers by Marangoni, Elisabetta, Laurent, Cécile, Coussy, Florence, El-Botty, Rania, Château-Joubert, Sophie, Servely, Jean-Luc, de Plater, Ludmilla, Assayag, Franck, Dahmani, Ahmed, Montaudon, Elodie, Nemati, Fariba, Fleury, Justine, Vacher, Sophie, Gentien, David, Rapinat, Audrey, Foidart, Pierre, Sounni, Nor Eddine, Noel, Agnès, Vincent-Salomon, Anne, Lae, Marick, Decaudin, Didier, Roman-Roman, Sergio, Bièche, Ivan, Piccart, Martine, Reyal, Fabien

“…Triple-negative breast cancer (TNBC) patients with residual disease after neoadjuvant chemotherapy have a poor outcome. We developed patient-derived xenografts…”
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