Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study

The outcomes of drug treatment for male infertility remain conjectural, with controversial study results. Our pilot study employed a randomized, placebo‐controlled, crossover methodology with intention‐to‐treat analysis. Thirty‐three men with idiopathic oligospermia were randomized to start either d...

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 91; no. 4; pp. 582 - 589
Main Authors:	Mbah, A U, Ndukwu, G O, Ghasi, S I, Shu, E N, Ozoemena, F N, Mbah, J O, Onodugo, O D, Ejim, E C, Eze, M I, Nkwo, P O, Okonkwo, P O
Format:	Journal Article
Language:	English
Published:	Basingstoke Blackwell Publishing Ltd 01-04-2012 Nature Publishing Group
Subjects:	Adult Biological and medical sciences Birth control Cross-Over Studies Dose-Response Relationship, Drug Female Gynecology. Andrology. Obstetrics Humans Infertility, Male - drug therapy Infertility, Male - epidemiology Lisinopril - administration & dosage Longitudinal Studies Male Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance Medical sciences Oligospermia - drug therapy Oligospermia - epidemiology Pharmacology. Drug treatments Pilot Projects Pregnancy Pregnancy Rate - trends Sperm Count - methods Sterility. Assisted procreation Young Adult Human Lisinopril Enzyme Low dose Idiopathic Enzyme inhibitor Male Crossover study Sterility Semen disorders Oligospermia Peptidases Randomization Peptidyl-dipeptidase A Hydrolases Peptidyl-dipeptidases Adult Antihypertensive agent Male genital diseases ACE inhibitor
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Summary:	The outcomes of drug treatment for male infertility remain conjectural, with controversial study results. Our pilot study employed a randomized, placebo‐controlled, crossover methodology with intention‐to‐treat analysis. Thirty‐three men with idiopathic oligospermia were randomized to start either daily oral lisinopril 2.5 mg (n = 17) or daily oral placebo (n = 16). Lisinopril was found to cause a normalization of seminal parameters in 53.6% of the participants. Although the mean ejaculate volume was unchanged (P ≥ 0.093), the total sperm cell count and the percentage of motile sperm cells increased (P ≤ 0.03 and P < 0.001, respectively), whereas the percentage of sperm cells with abnormal morphology decreased (P ≤ 0.04). The pregnancy rate was 48.5%, and there was no serious adverse drug event. It is concluded, albeit cautiously, that prolonged treatment with 2.5 mg/day of oral lisinopril may be well tolerated in normotensive men with idiopathic oligospermia, may improve sperm quantity and quality, and may enhance fertility in approximately half of those treated. Clinical Pharmacology & Therapeutics (2012); 91 4, 582–589. doi:10.1038/clpt.2011.265
Bibliography:	ark:/67375/WNG-ZCJWBR50-4 istex:79A24224019405EF5EF58781536827C7DA465506 ArticleID:CPTCLPT2011265 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2011.265