Oncogenic Human Papillomavirus Infection and Genotype Characterization among Women in Orodara, Western Burkina Faso

Cervical cancer usually occurs several years after persistent infection with oncogenic or high-risk human papillomavirus. The objective of this study was to determine carriage of 14 genotypes of high-risk human papillomavirus among women at Orodara and then characterize the genotypes found in these...

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Bibliographic Details
Published in:	Pakistan journal of biological sciences Vol. 19; no. 7; pp. 306 - 311
Main Authors:	Traore, I M A, Zohoncon, T M, Ndo, O, Djigma, F W, Obiri-Yeboah, D, Compaore, T R, Guigma, S P, Yonli, A T, Traore, G, Ouedraogo, P, Ouedraogo, C M R, Traore, Y, Simpore, J
Format:	Journal Article
Language:	English
Published:	Pakistan 2016
Subjects:	Adolescent Adult Aged Burkina Faso - epidemiology Cell Transformation, Viral DNA, Viral - genetics Female Genotype Human Papillomavirus DNA Tests Humans Middle Aged Molecular Epidemiology Oncogene Proteins, Viral - genetics Papillomaviridae - classification Papillomaviridae - genetics Papillomavirus Infections - diagnosis Papillomavirus Infections - epidemiology Papillomavirus Infections - virology Polymerase Chain Reaction Precancerous Conditions - diagnosis Precancerous Conditions - epidemiology Precancerous Conditions - virology Predictive Value of Tests Prevalence Risk Factors Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - virology Young Adult cervix prevalence High-risk HPV Western Burkina Faso genotypes real-time PCR cervical cancer women
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Summary:	Cervical cancer usually occurs several years after persistent infection with oncogenic or high-risk human papillomavirus. The objective of this study was to determine carriage of 14 genotypes of high-risk human papillomavirus among women at Orodara and then characterize the genotypes found in these women. From June to July 2015, 120 women from the general population were recruited in the health district of Orodara. They voluntarily agreed to participate in the study. Endocervical samples were taken from these women prior to screening for precancerous lesions by visual inspection with acetic acid and lugol's iodine. Identification of high-risk human papillomavirus genotype was done using real-time PCR. High-risk human papillomavirus prevalence was 38.3% and the most common genotypes were HPV 52 (25.4%), HPV 33 (20.6%) and HPV 59 (11.1%). The HPV 66 was also identified with a prevalence of 9.5%. The HPV 16 and HPV 18 which are frequently associated with cancer worldwide were not found among the most frequent oncogenic HPV in women in Orodara.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1028-8880
DOI:	10.3923/pjbs.2016.306.311