Search Results - "Ncokazi, Kanyile K."

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance by Dubar, Faustine, Egan, Timothy J, Pradines, Bruno, Kuter, David, Ncokazi, Kanyile K, Forge, Delphine, Paul, Jean-François, Pierrot, Christine, Kalamou, Hadidjatou, Khalife, Jamal, Buisine, Eric, Rogier, Christophe, Vezin, Hervé, Forfar, Isabelle, Slomianny, Christian, Trivelli, Xavier, Kapishnikov, Sergey, Leiserowitz, Leslie, Dive, Daniel, Biot, Christophe

“…Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot…”
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Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface by Egan, Timothy J., Chen, Jeff Y-J., de Villiers, Katherine A., Mabotha, Tebogo E., Naidoo, Kevin J., Ncokazi, Kanyile K., Langford, Steven J., McNaughton, Don, Pandiancherri, Shveta, Wood, Bayden R.

“…Several blood-feeding organisms, including the malaria parasite detoxify haem released from host haemoglobin by conversion to the insoluble crystalline…”
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Insights into the Role of Heme in the Mechanism of Action of Antimalarials by Combrinck, Jill M, Mabotha, Tebogo E, Ncokazi, Kanyile K, Ambele, Melvin A, Taylor, Dale, Smith, Peter J, Hoppe, Heinrich C, Egan, Timothy J

“…By using cell fractionation and measurement of Fe­(III)­heme-pyridine, the antimalarial chloroquine (CQ) has been shown to cause a dose-dependent decrease in…”
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A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds by Ncokazi, Kanyile K., Egan, Timothy J.

“…Antimalarial drugs such as chloroquine are believed to act by inhibiting hemozoin formation in the food vacuole of the malaria parasite. We have developed a…”
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Crystallization of synthetic haemozoin (beta-haematin) nucleated at the surface of lipid particles by Hoang, Anh N, Ncokazi, Kanyile K, de Villiers, Katherine A, Wright, David W, Egan, Timothy J

“…The mechanism of formation of haemozoin, a detoxification by-product of several blood-feeding organisms including malaria parasites, has been a subject of…”
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Quinoline antimalarials decrease the rate of β-hematin formation by Egan, Timothy J., Ncokazi, Kanyile K.

“…The strength of inhibition of β-hematin (synthetic hemozoin or malaria pigment) formation by the quinoline antimalarial drugs chloroquine, amodiaquine,…”
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The Mechanism of β-Hematin Formation in Acetate Solution. Parallels between Hemozoin Formation and Biomineralization Processes by Egan, Timothy J, Mavuso, Winile W, Ncokazi, Kanyile K

“…Formation of β-hematin in acidic acetate solution has been investigated using quantitative infrared spectroscopy, X-ray diffraction, and scanning and…”
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Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX by Egan, Timothy J, Ncokazi, Kanyile K

“…Enthalpy-entropy compensation in the interaction of quinoline antimalarials with ferriprotoporphyrin IX (Fe(III)PPIX) in 40% aqueous dimethyl sulfoxide (DMSO)…”
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