In silico Mechanics of Stem Cells Intramyocardially Transplanted with a Biomaterial Injectate for Treatment of Myocardial Infarction

Biomaterial and stem cell delivery are promising approaches to treating myocardial infarction. However, the mechanical and biochemical mechanisms underlying the therapeutic benefits require further clarification. This study aimed to assess the deformation of stem cells injected with the biomaterial...

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Bibliographic Details
Published in:	Cardiovascular engineering and technology
Main Authors:	Motchon, Y D, Sack, K L, Sirry, M S, Nchejane, N J, Abdalrahman, T, Nagawa, J, Kruger, M, Pauwels, E, Van Loo, D, De Muynck, A, Van Hoorebeke, L, Davies, N H, Franz, T
Format:	Journal Article
Language:	English
Published:	United States 23-05-2024
Subjects:	Finite element method Cell therapy Biomaterial injection therapy Cell mechanics
Online Access:	Get full text
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Summary:	Biomaterial and stem cell delivery are promising approaches to treating myocardial infarction. However, the mechanical and biochemical mechanisms underlying the therapeutic benefits require further clarification. This study aimed to assess the deformation of stem cells injected with the biomaterial into the infarcted heart. A microstructural finite element model of a mid-wall infarcted myocardial region was developed from ex vivo microcomputed tomography data of a rat heart with left ventricular infarct and intramyocardial biomaterial injectate. Nine cells were numerically seeded in the injectate of the microstructural model. The microstructural and a previously developed biventricular finite element model of the same rat heart were used to quantify the deformation of the cells during a cardiac cycle for a biomaterial elastic modulus (E ) ranging between 4.1 and 405,900 kPa. The transplanted cells' deformation was largest for E = 7.4 kPa, matching that of the cells, and decreased for an increase and decrease in E . The cell deformation was more sensitive to E changes for softer (E ≤ 738 kPa) than stiffer biomaterials. Combining the microstructural and biventricular finite element models enables quantifying micromechanics of transplanted cells in the heart. The approach offers a broader scope for in silico investigations of biomaterial and cell therapies for myocardial infarction and other cardiac pathologies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1869-408X 1869-4098
DOI:	10.1007/s13239-024-00734-1