Search Results - "Nazzaro, Matthew"

Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma by Rajendran, Sakthi, Hu, Yang, Canella, Alessandro, Peterson, Clayton, Gross, Amy, Cam, Maren, Nazzaro, Matthew, Haffey, Abigail, Serin-Harmanci, Akdes, Distefano, Rosario, Nigita, Giovanni, Wang, Wesley, Kreatsoulas, Daniel, Li, Zihai, Sepeda, Jesse A., Sas, Andrew, Hester, Mark E., Miller, Katherine E., Elemento, Olivier, Roberts, Ryan D., Holland, Eric C., Rao, Ganesh, Mardis, Elaine R., Rajappa, Prajwal

“…Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in high-grade gliomas (HGGs). In particular, myeloid cells are known to…”
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Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment by Canella, Alessandro, Nazzaro, Matthew, Rajendran, Sakthi, Schmitt, Claire, Haffey, Abigail, Nigita, Giovanni, Thomas, Diana, Lyberger, Justin M., Behbehani, Gregory K., Amankulor, Nduka M., Mardis, Elaine R., Cripe, Timothy P., Rajappa, Prajwal

“…Gliomas are one of the leading causes of cancer-related death in the adolescent and young adult (AYA) population. Two-thirds of AYA glioma patients are…”
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Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation by Penter, Livius, Zhang, Yi, Savell, Alexandra, Huang, Teddy, Cieri, Nicoletta, Thrash, Emily M., Kim-Schulze, Seunghee, Jhaveri, Aashna, Fu, Jingxin, Ranasinghe, Srinika, Li, Shuqiang, Zhang, Wandi, Hathaway, Emma S., Nazzaro, Matthew, Kim, Haesook T., Chen, Helen, Thurin, Magdalena, Rodig, Scott J., Severgnini, Mariano, Cibulskis, Carrie, Gabriel, Stacey, Livak, Kenneth J., Cutler, Corey, Antin, Joseph H., Nikiforow, Sarah, Koreth, John, Ho, Vincent T., Armand, Philippe, Ritz, Jerome, Streicher, Howard, Neuberg, Donna, Hodi, F. Stephen, Gnjatic, Sacha, Soiffer, Robert J., Liu, X. Shirley, Davids, Matthew S., Bachireddy, Pavan, Wu, Catherine J.

“…Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune…”
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Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival by de Klerk, Leonie K, Patel, Anuj K, Derks, Sarah, Pectasides, Eirini, Augustin, Jeremy, Uduman, Mohamed, Raman, Nihal, Akarca, Fahire G, McCleary, Nadine J, Cleary, James M, Rubinson, Douglas A, Clark, Jeffrey W, Fitzpatrick, Bridget, Brais, Lauren K, Cavanaugh, Megan E, Rode, Amanda J, Jean, Melissa G, Lizotte, Patrick H, Nazzaro, Matthew J, Severgnini, Mariano, Zheng, Hui, Fuchs, Charles S, Enzinger, Peter C, Bass, Adam J

“…BackgroundImmune checkpoint inhibitors have revolutionized cancer treatment, but the benefits in refractory patients with esophageal cancer have been modest…”
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406 Reprogramming the glioma immunosuppressive tumor microenvironment with engineered myeloid cells that release IL-2 to delay malignant progression by Canella, Alessandro, Nazzaro, Matthew, Schmitt, Claire, Haffey, Abigail, Nigita, Giovanni, Behbehani, Gregory K, Rajappa, Prajwal

“…BackgroundEach year in the United States, approximately 20,000 new cases of gliomas are diagnosed in children, adolescents, and adults. These disparate brain…”
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High-Throughput Mass Cytometry Staining for Immunophenotyping Clinical Samples by Thrash, Emily M., Kleinsteuber, Katja, Hathaway, Emma S., Nazzaro, Matthew, Haas, Eric, Hodi, F. Stephen, Severgnini, Mariano

“…As mass cytometry (MC) is implemented in clinical settings, the need for robust, validated protocols that reduce batch effects between samples becomes…”
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Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial by Ott, Patrick A, Nazzaro, Matthew, Pfaff, Kathleen L, Gjini, Evisa, Felt, Kristen D, Wolff, Jacquelyn O, Buchbinder, Elizabeth I, Haq, Rizwan, Sullivan, Ryan J, Lawrence, Donald P, McDermott, David F, Severgnini, Mariano, Giobbie-Hurder, Anita, Rodig, Scott J, Stephen Hodi, F

“…BackgroundAngiogenic factors promote the growth of tumor vasculature, modulate lymphocyte trafficking into tumors, and inhibit maturation of dendritic cells…”
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Simplified mass cytometry protocol for in-plate staining, barcoding, and cryopreservation of human PBMC samples in clinical trials by Abrecht, Charlotte, Hallisey, Margaret, Dennis, Jenna, Nazzaro, Matthew, Brainard, Martha, Hathaway, Emma, Schork, Abigail N., Hodi, F. Stephen, Severgnini, Mariano, Baginska, Joanna

“…With the increasing use of mass cytometry in clinical research, a simplified and standardized protocol for immunophenotyping human peripheral blood mononuclear…”
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Trabectedin modulates the glioma innate and adaptive immune microenvironment in vivo by Nazzaro, Matthew, Rajappa, Prajwal, Currier, Mark, Glaspell, Andrea, Behbehani, Gregory, Cripe, Timothy

“…Abstract Low-grade gliomas (LGG) are the most common brain tumor in adolescents and young adults. LGG are neglected in the field of research due to their low…”
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IMMU-15. CD74/MIF SIGNALING AXIS DISRUPTION IN BONE MARROW-DERIVED MYELOID CELLS DELAYS MALIGNANT PROGRESSION IN A PRECLINICAL MODEL OF GLIOMA by Canella, Alessandro, Rajendran, Sakthi, Nazzaro, Matthew, Schmitt, Claire, Kreatsoulas, Daniel, Wang, Wesley, Rajappa, Prajwal

“…Abstract INTRODUCTION CD74, a chaperone associated with the major histocompatibility complex class II (MHC-II), plays a crucial role in assembling and…”
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TMIC-59. IL-2 SECRETING ENGINEERED MYELOID CELLS POTENTIATE CYTOTOXIC EFFECTOR CELL ACTIVATION TO DELAY MALIGNANT PROGRESSION IN A PRECLINICAL MODEL OF GLIOMA by Canella, Alessandro, Nazzaro, Matthew, Haffey, Abigail, Schmitt, Claire, Behbehani, Gregory, Rajappa, Prajwal

“…Abstract INTRODUCTION Gliomas are the most prevalent brain tumor in the adolescent and young adult population (AYA) and one of the leading causes of…”
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EXTH-97. BONE MARROW-DERIVED ENGINEERED MYELOID CELLS ENHANCE THE TRAFFICKING AND ACTIVATION OF CYTOTOXIC T CELLS IN THE GLIOMA MICROENVIRONMENT by Canella, Alessandro, Nazzaro, Matthew, Schmitt, Claire, Rajendran, Sakthi, Haffey, Abigail, Nigita, Giovanni, Thomas, Diana, Rajappa, Prajwal

“…Abstract INTRODUCTION Gliomas are the most prevalent type of brain tumors in the adolescent and young adult population (AYA) and one of the leading causes of…”
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DIPG-16. Evaluation of myeloid component of DIPG microenvironment by Mishra, Deepak, Rajendran, Sakthi, Zhu, Xiaoting, Nazzaro, Matthew, Kumar, Shiva Senthil, Mchugh, Todd, Rajappa, Prajwal, Drissi, Rachid

“…Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable disease of the central nervous system in children with median overall survival…”
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BRAF V600E in a preclinical model of pleomorphic Xanthoastrocytoma: Analysis of the tumor microenvironment and immune cell infiltration dynamics in vivo by Canella, Alessandro, Nazzaro, Matthew, Artomov, Mykyta, Rao Venkata, Lakshmi Prakruthi, Thomas, Diana, Lyberger, Justin, Ukhatov, Aleksandr, Xing, Yao Lulu, Miller, Katherine, Behbehani, Gregory, Amankulor, Nduka M, Petritsch, Claudia Katharina, Rajappa, Prajwal

“…Low-grade glioma (LGG) is the most common brain tumor affecting pediatric patients (pLGG) and BRAF mutations constitute the most frequent genetic alterations…”
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Abstract 6397: Immune profiling for improving responsiveness to ipilimumab plus nivolumab checkpoint blockade treatment in patients with metastatic melanoma by Baginska, Joanna, Chen, Jiajia, Tarantino, Giuseppe, Giobbie-Hurder, Anita, Weirather, Jason L., Severgnini, Mariano, Manos, Michael, Burke, Kelly, Russell, Janice D., Brainard, Martha, Gabriel, Elizabeth, Brennick, Ryan, Nazzaro, Matthew, Hathaway, Emma, Holovatska, Marta, Manuszak, Claire, Ranashinge, Srinika, Liu, David, Hodi, F. Stephen

“…Abstract Background:aCTLA-4 and aPD-1 combination therapy has significantly improved clinical outcomes in patients with metastatic melanoma, with 50%-60% of…”
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Immune Reconstitution following High-Dose Chemotherapy and Autologous Stem Cell Transplantation with or without Pembrolizumab Maintenance Therapy in Patients with Lymphoma by Merryman, Reid W., Redd, Robert, Jeter, Erin, Wong, Jeff L., McHugh, Kristin, Reynolds, Carol, Nazzaro, Matthew, Varden, Aine, Brown, Jennifer R., Crombie, Jennifer L., Davids, Matthew S., Fisher, David C., Jacobsen, Eric, Jacobson, Caron A., Kim, Austin I., LaCasce, Ann S., Ng, Samuel Y., Odejide, Oreofe O., Parry, Erin M., Dahi, Parastoo B., Nieto, Yago, Joyce, Robin M., Chen, Yi-Bin, Herrera, Alex F., Armand, Philippe, Ritz, Jerome

“…•Post-autologous stem cell transplantation (ACST) pembrolizumab maintenance therapy did not impact the recovery of T cells.•Pembrolizumab was associated with…”
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