Search Results - "Nazzareno, Cannella"

Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse by Vengeliene, Valentina, Cannella, Nazzareno, Takahashi, Tatiane, Spanagel, Rainer

“…Rationale The glutamatergic system plays a key role in the maintenance of drug use and development of drug-related conditioned behaviours. In particular,…”
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Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI by Cannella, Nazzareno, Cosa-Linan, Alejandro, Takahashi, Tatiane, Weber-Fahr, Wolfgang, Spanagel, Rainer

“…Cocaine addiction develops as a continuum from recreational to habitual and ultimately compulsive drug use. Cocaine addicts show reduced brain activity…”
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Effect of Glucocorticoid Receptor Antagonism on Alcohol Self-Administration in Genetically-Selected Marchigian Sardinian Alcohol-Preferring and Non-Preferring Wistar Rats by Benvenuti, Federica, Cannella, Nazzareno, Stopponi, Serena, Soverchia, Laura, Ubaldi, Massimo, Lunerti, Veronica, Vozella, Valentina, Cruz, Bryan, Roberto, Marisa, Ciccocioppo, Roberto

“…Alcoholism is a chronically relapsing disorder characterized by high alcohol intake and a negative emotional state during abstinence, which contributes to…”
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Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders by Ubaldi, Massimo, Cannella, Nazzareno, Borruto, Anna Maria, Petrella, Michele, Micioni Di Bonaventura, Maria Vittoria, Soverchia, Laura, Stopponi, Serena, Weiss, Friedbert, Cifani, Carlo, Ciccocioppo, Roberto

“…Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics…”
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NOP-Related Mechanisms in Substance Use Disorders by Ciccocioppo, Roberto, Borruto, Anna Maria, Domi, Ana, Teshima, Koji, Cannella, Nazzareno, Weiss, Friedbert

“…Nociceptin/orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995 and has been widely studied since. The role of the N/OFQ system in drug…”
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Modulation of Gut Microbiota and Neuroprotective Effect of a Yeast-Enriched Beer by Cecarini, Valentina, Gogoi, Olee, Bonfili, Laura, Veneruso, Iolanda, Pacinelli, Giada, De Carlo, Sara, Benvenuti, Federica, D?Argenio, Valeria, Angeletti, Mauro, Cannella, Nazzareno, Eleuteri, Anna Maria

“…Beer is the most consumed alcoholic beverage worldwide. It is rich in nutrients, and with its microbial component it could play a role in gut microbiota…”
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Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats by Vozella, Valentina, Cruz, Bryan, Natividad, Luis A, Benvenuti, Federica, Cannella, Nazzareno, Edwards, Scott, Zorrilla, Eric P, Ciccocioppo, Roberto, Roberto, Marisa

“…Marchigian Sardinian alcohol-preferring (msP) rats serve as a unique model of heightened alcohol preference and anxiety disorders. Their innate enhanced stress…”
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Editorial: Neurobehavioural Mechanisms of Resilience and Vulnerability in Addictive Disorders by Aguilar, Maria A, Cannella, Nazzareno, Ferragud, Antonio, Spanagel, Rainer

“…A better understanding of the biological bases of transition from recreational drug use to drug abuse occurring in vulnerable drug users could help to tailor…”
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Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors by Shen, Qianwei, Deng, Yulin, Ciccocioppo, Roberto, Cannella, Nazzareno

“…Cocaine addiction is a widespread psychiatric condition still waiting for approved efficacious medications. Previous studies suggested that simultaneous…”
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Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study by Domi, Ana, Stopponi, Serena, Domi, Esi, Ciccocioppo, Roberto, Cannella, Nazzareno

“…Recent animal models of alcohol use disorder (AUD) are centered in capturing individual vulnerability differences in disease progression. Here, we used…”
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Multi-dimensional characterization of an alcohol dependence-prone phenotype in rats by Ana, Domi, Roberto, Ciccocioppo, Nazzareno, Cannella, Massimo, Ubaldi

“…In this study, we adapted the DSM-IV/5 based three-criteria model of cocaine addiction to study individual differences in alcohol dependence in rats. Rats were…”
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Long access heroin self-administration significantly alters gut microbiome composition and structure by Greenberg, Jonathan M, Winters, Andrew D, Zagorac, Branislava, Kracht, David J, Francescutti, Dina M, Cannella, Nazzareno, Ciccocioppo, Roberto, Woods, Leah C Solberg, Mackle, James, Hardiman, Gary T, Kuhn, Brittany N, Kalivas, Peter W, Kuhn, Donald M, Angoa-Perez, Mariana

“…It is well known that chronic opioid use disorder is associated with alterations in gastrointestinal (GI) function that include constipation, reduced motility,…”
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A Role for Neuropeptide S in Alcohol and Cocaine Seeking by Cannella, Nazzareno, Borruto, Anna Maria, Petrella, Michele, Micioni Di Bonaventura, Maria Vittoria, Soverchia, Laura, Cifani, Carlo, De Carlo, Sara, Domi, Esi, Ubaldi, Massimo

“…The neuropeptide S (NPS) is the endogenous ligand of the NPS receptor (NPSR). The NPSR is widely expressed in brain regions that process emotional and…”
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Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system by Kallupi, Marsida, Cannella, Nazzareno, Economidou, Daina, Ubaldi, Massimo, Ruggeri, Barbara, Weiss, Friedbert, Massi, Maurizio, Marugan, Juan, Heilig, Markus, Bonnavion, Patricia, de Lecea, Luis, Ciccocioppo, Roberto, Bloom, Floyd

“…Drug addiction is a chronic relapsing disorder characterized by compulsive drug seeking and use. Environmental conditioning factors are among the major…”
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Network-Based Discovery of Opioid Use Vulnerability in Rats Using the Bayesian Stochastic Block Model by Allen, Carter, Kuhn, Brittany N, Cannella, Nazzareno, Crow, Ayteria D, Roberts, Analyse T, Lunerti, Veronica, Ubaldi, Massimo, Hardiman, Gary, Solberg Woods, Leah C, Ciccocioppo, Roberto, Kalivas, Peter W, Chung, Dongjun

“…Opioid use disorder is a psychological condition that affects over 200,000 people per year in the U.S., causing the Centers for Disease Control and Prevention…”
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[18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior by Cannella, Nazzareno, Cosa-Linan, Alejandro, Roscher, Mareike, Takahashi, Tatiane T, Vogler, Nils, Wängler, Björn, Spanagel, Rainer

“…The DSM5-based dimensional diagnostic approach defines substance use disorders on a continuum from recreational drug use to habitual and ultimately addicted…”
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Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat by Garcia-Rivas, Vernon, Fiancette, Jean-François, Cannella, Nazzareno, Carbo-Gas, Maria, Renault, Prisca, Tostain, Jessica, Deroche-Gamonet, Véronique

“…Nicotine is acknowledged as the key addictive compound of tobacco. Varenicline (Champix or Chantix ), mainly acting as a partial agonist at the α4β2 nicotinic…”
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NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference by Li, Hongwu, Scuppa, Giulia, Shen, Qianwei, Masi, Alessio, Nasuti, Cinzia, Cannella, Nazzareno, Ciccocioppo, Roberto

“…Cocaine dependence is a psychiatric condition for which effective medications are still lacking. Published data indicate that an increase in…”
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The role of hypocretin in driving arousal and goal-oriented behaviors by Boutrel, Benjamin, Cannella, Nazzareno, de Lecea, Luis

“…Abstract The hypocretins (Hcrts), also called orexins, are two neuropeptides secreted by a few thousand neurons restricted to the lateral hypothalamus. The…”
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Cebranopadol, a novel long-acting opioid agonist with low abuse liability, to treat opioid use disorder: Preclinical evidence of efficacy by Cannella, Nazzareno, Lunerti, Veronica, Shen, Qianwei, Li, Hongwu, Benvenuti, Federica, Soverchia, Laura, Narendran, Rajesh, Weiss, Friedbert, Ciccocioppo, Roberto

“…Maintenance therapy with buprenorphine and methadone is the gold standard pharmacological treatment for opioid use disorder (OUD). Despite these compounds…”
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