Search Results - "Nazneen Aziz"

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology by Richards, Sue, Aziz, Nazneen, Bale, Sherri, Bick, David, Das, Soma, Gastier-Foster, Julie, Grody, Wayne W., Hegde, Madhuri, Lyon, Elaine, Spector, Elaine, Voelkerding, Karl, Rehm, Heidi L.

“…Disclaimer: These ACMG Standards and Guidelines were developed primarily as an educational resource for clinical laboratory geneticists to help them provide…”
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Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice by Santos, Angélica M, Jung, Jason, Aziz, Nazneen, Kissil, Joseph L, Puré, Ellen

“…Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis, angiogenesis, and metastasis. However, the mechanisms by which they…”
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College of American Pathologists' laboratory standards for next-generation sequencing clinical tests by Aziz, Nazneen, Zhao, Qin, Bry, Lynn, Driscoll, Denise K, Funke, Birgit, Gibson, Jane S, Grody, Wayne W, Hegde, Madhuri R, Hoeltge, Gerald A, Leonard, Debra G B, Merker, Jason D, Nagarajan, Rakesh, Palicki, Linda A, Robetorye, Ryan S, Schrijver, Iris, Weck, Karen E, Voelkerding, Karl V

“…The higher throughput and lower per-base cost of next-generation sequencing (NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical…”
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A collaborative translational research framework for evaluating and implementing the appropriate use of human genome sequencing to improve health by Khoury, Muin J, Feero, W Gregory, Chambers, David A, Brody, Lawrence C, Aziz, Nazneen, Green, Robert C, Janssens, A Cecile J W, Murray, Michael F, Rodriguez, Laura Lyman, Rutter, Joni L, Schully, Sheri D, Winn, Deborah M, Mensah, George A

“…In a Policy Forum, Muin Khoury and colleagues discuss research on the clinical application of genome sequencing data…”
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Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context by Chen, Hongmin, Wilkins, Leon M., Aziz, Nazneen, Cannings, Christopher, Wyllie, David H., Bingle, Colin, Rogus, John, Beck, James D., Offenbacher, Steven, Cork, Michael J., Rafie-Kolpin, Maryam, Hsieh, Chung-Ming, Kornman, Kenneth S., Duff, Gordon W.

“…We questioned the significance of haplotype structure in gene regulation by testing whether individual single nucleotide polymorphisms (SNPs) within a gene…”
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Correction: A collaborative translational research framework for evaluating and implementing the appropriate use of human genome sequencing to improve health by Khoury, Muin J, Feero, W Gregory, Chambers, David A, Brody, Lawrence C, Aziz, Nazneen, Green, Robert C, Janssens, A Cecile J W, Murray, Michael F, Rodriguez, Laura Lyman, Rutter, Joni L, Schully, Sheri D, Winn, Deborah M, Mensah, George A

“…[This corrects the article DOI: 10.1371/journal.pmed.1002631.]…”
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Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease by Pennisi, Angela, Li, Xin, Ling, Wen, Khan, Sharmin, Gaddy, Dana, Suva, Larry J., Barlogie, Bart, Shaughnessy, John D., Aziz, Nazneen, Yaccoby, Shmuel

“…Summary Dipeptidyl peptidase (DPP) IV activity and/or structure homologues (DASH) are serine proteases implicated in tumourigenesis. We previously found that a…”
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Iron Regulates Ferritin mRNA Translation through a Segment of Its 5′ Untranslated Region by Aziz, Nazneen, Munro, Hamish N.

“…In previous studies, we showed that acute administration of iron to intact rats or to rat hepatoma cells in culture induces synthesis of the iron-storage…”
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Good laboratory practice for clinical next-generation sequencing informatics pipelines by Gargis, Amy S, Kalman, Lisa, Bick, David P, da Silva, Cristina, Dimmock, David P, Funke, Birgit H, Gowrisankar, Sivakumar, Hegde, Madhuri R, Kulkarni, Shashikant, Mason, Christopher E, Nagarajan, Rakesh, Voelkerding, Karl V, Worthey, Elizabeth A, Aziz, Nazneen, Barnes, John, Bennett, Sarah F, Bisht, Himani, Church, Deanna M, Dimitrova, Zoya, Gargis, Shaw R, Hafez, Nabil, Hambuch, Tina, Hyland, Fiona C L, Luna, Ruth Ann, MacCannell, Duncan, Mann, Tobias, McCluskey, Megan R, McDaniel, Timothy K, Ganova-Raeva, Lilia M, Rehm, Heidi L, Reid, Jeffrey, Campo, David S, Resnick, Richard B, Ridge, Perry G, Salit, Marc L, Skums, Pavel, Wong, Lee-Jun C, Zehnbauer, Barbara A, Zook, Justin M, Lubin, Ira M

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Demographic differences in the utilization of clinical and direct‐to‐consumer genetic testing by Carroll, Nikki M., Blum‐Barnett, Erica, Madrid, Sarah D., Jonas, Cabell, Janes, Kristen, Alvarado, Monica, Bedoy, Ruth, Paolino, Valerie, Aziz, Nazneen, McGlynn, Elizabeth A., Burnett‐Hartman, Andrea N.

“…Genetic testing has increased over the last decade due to growth in the number of clinical and direct‐to‐consumer (DTC) tests. However, there is uncertainty…”
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Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions by Huang, Yan, Simms, Avis E., Mazur, Anna, Wang, Sophie, León, Noel R., Jones, Barry, Aziz, Nazneen, Kelly, Thomas

“…Fibroblast activation protein-α (FAP) is a cell surface, serine protease of the post-prolyl peptidase family that is expressed in human breast cancer but not…”
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Methods-Based Proficiency Testing in Molecular Genetic Pathology by Schrijver, Iris, Aziz, Nazneen, Jennings, Lawrence J, Richards, Carolyn Sue, Voelkerding, Karl V, Weck, Karen E

“…This Perspectives article describes methods-based proficiency testing (MBPT), the benefits and limitations of MBPT, why the time is right for MBPT in molecular…”
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Both subunits of rat liver ferritin are regulated at a translational level by iron induction by Aziz, Nazneen, Munro, Hamish N.

“…A few hours after administering iron to rats, liver ferritin synthesis increases several fold. However, Northern blot analysis with cDNA probes for ferritin…”
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Opportunities and challenges associated with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology by Schrijver, Iris, Aziz, Nazneen, Farkas, Daniel H, Furtado, Manohar, Gonzalez, Andrea Ferreira, Greiner, Timothy C, Grody, Wayne W, Hambuch, Tina, Kalman, Lisa, Kant, Jeffrey A, Klein, Roger D, Leonard, Debra G B, Lubin, Ira M, Mao, Rong, Nagan, Narasimhan, Pratt, Victoria M, Sobel, Mark E, Voelkerding, Karl V, Gibson, Jane S

“…This report of the Whole Genome Analysis group of the Association for Molecular Pathology illuminates the opportunities and challenges associated with clinical…”
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Response to Biesecker and Harrison by Richards, C Sue, Aziz, Nazneen, Bale, Sherri, Bick, David, Das, Soma, Gastier-Foster, Julie, Grody, Wayne W, Hegde, Madhuri, Lyon, Elaine, Spector, Elaine, Voelkerding, Karl, Rehm, Heidi L

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Return of Research-Related Genetic Test Results and Genetic Discrimination Concerns: Facilitators and Barriers of Genetic Research Participation in Diverse Groups by Burnett-Hartman, Andrea N, Blum-Barnett, Erica, Carroll, Nikki M, Madrid, Sarah D, Jonas, Cabell, Janes, Kristen, Alvarado, Monica, Bedoy, Ruth, Paolino, Valerie, Aziz, Nazneen, McGlynn, Elizabeth A

“…Most genetics studies lack the diversity necessary to ensure that all groups benefit from genetic research. To explore facilitators and barriers to genetic…”
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Ke 6 Gene by Maxwell, Michele M., Nearing, Jacqueline, Aziz, Nazneen

“…Ke 6 gene is a newly identified gene located in the major histocompatibility complex and is a candidate steroid dehydrogenase gene because of structural…”
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Physician Experience with Direct-To-Consumer Genetic Testing in Kaiser Permanente by Jonas, M Cabell, Suwannarat, Pim, Burnett-Hartman, Andrea, Carroll, Nikki, Turner, Michelle, Janes, Kristen, Truong, Christine, Blum-Barnett, Erica, Aziz, Nazneen, McGlynn, Elizabeth A

“…Health systems and physicians nationwide aspire to consistently and reliably apply genetic and genomic information to guide disease prevention, management, and…”
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Principles and Recommendations for Standardizing the Use of the Next-Generation Sequencing Variant File in Clinical Settings by Lubin, Ira M, Aziz, Nazneen, Babb, Lawrence J, Ballinger, Dennis, Bisht, Himani, Church, Deanna M, Cordes, Shaun, Eilbeck, Karen, Hyland, Fiona, Kalman, Lisa, Landrum, Melissa, Lockhart, Edward R, Maglott, Donna, Marth, Gabor, Pfeifer, John D, Rehm, Heidi L, Roy, Somak, Tezak, Zivana, Truty, Rebecca, Ullman-Cullere, Mollie, Voelkerding, Karl V, Worthey, Elizabeth A, Zaranek, Alexander W, Zook, Justin M

“…A national workgroup convened by the Centers for Disease Control and Prevention identified principles and made recommendations for standardizing the…”
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Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations by Attur, Mukundan, Wang, Hwa-Ying, Kraus, Virginia Byers, Bukowski, Jack F, Aziz, Nazneen, Krasnokutsky, Svetlana, Samuels, Jonathan, Greenberg, Jeffrey, McDaniel, Gary, Abramson, Steven B, Kornman, Kenneth S

“…A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. To determine whether…”
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