Search Results - "Nazmi, Kamran"
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Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes
Published in Proceedings of the National Academy of Sciences - PNAS (03-11-2020)“…Priming of CD8⁺ T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine…”
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Sialagogic Effects Through Olfactory Stimulation with Mastic Resin and α-pinene Volatiles in vivo
Published in Biomedicine & pharmacotherapy (01-12-2023)“…Xerostomia, often associated with decreased saliva quality, poses challenges due to limited treatment efficacy. This study aimed to investigate alternative…”
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D-LL-31 enhances biofilm-eradicating effect of currently used antibiotics for chronic rhinosinusitis and its immunomodulatory activity on human lung epithelial cells
Published in PloS one (16-12-2020)“…Chronic rhinosinusitis (CRS) is a chronic disease that involves long-term inflammation of the nasal cavity and paranasal sinuses. Bacterial biofilms present on…”
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EphA2 Targeted Doxorubicin-Nanoliposomes for Osteosarcoma Treatment
Published in Pharmaceutical research (01-12-2017)“…ABSTRACT Purpose To employ Doxorubicin-loaded liposomes, modified with YSA-peptide to target EphA2, to reduce adverse effects against primary bone cells and…”
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The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria
Published in Blood (22-01-2009)“…The plasma membrane glycoprotein receptor CD163 is a member of the scavenger receptor cystein-rich (SRCR) superfamily class B that is highly expressed on…”
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Scent of relief: Mastic resin scent recovers salivation in chronic dry mouth patients
Published in Biomedicine & pharmacotherapy (01-09-2024)“…Olfactory stimulation with mastic resin, derived from the Pistacia lentiscus tree, demonstrated a bona fide sialagogic effect in healthy volunteers [1]. Its…”
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Characterization of oral polymorphonuclear neutrophils in periodontitis patients: a case-control study
Published in BMC oral health (24-08-2018)“…Maintaining oral health is a continuous and dynamic process that also involves the immune system. Polymorphonuclear neutrophils (PMNs) migrate from blood…”
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Lubricating properties of chewing stimulated whole saliva from patients suffering from xerostomia
Published in Clinical oral investigations (01-07-2021)“…Objectives The study aimed to quantify the lubricating properties of chewing stimulated whole saliva from healthy controls ( n = 22), from patients suffering…”
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A rapid, non-invasive tool for periodontitis screening in a medical care setting
Published in BMC oral health (23-05-2019)“…Since periodontitis is bi-directionally associated with several systemic diseases, such as diabetes mellitus and cardiovascular diseases, it is important for…”
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Synergistic effects of LFchimera and antibiotic against planktonic and biofilm form of Aggregatibacter actinomycetemcomitans
Published in PloS one (22-07-2019)“…Adjunctive use of antibiotics in periodontal treatment have limitations and disadvantages including bacterial resistance. Antimicrobial peptides (AMPs) are…”
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Human salivary peptide histatin‐1 stimulates epithelial and endothelial cell adhesion and barrier function
Published in The FASEB journal (01-09-2017)“…ABSTRACT Histatins are multifunctional histidine‐rich peptides secreted by the salivary glands and exclusively present in the saliva of higher primates, where…”
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Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells
Published in Wound repair and regeneration (01-01-2016)“…Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming…”
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Histatin‐1, a histidine‐rich peptide in human saliva, promotes cell‐substrate and cell‐cell adhesion
Published in The FASEB journal (01-08-2015)“…Histatins (Hsts) are histidine‐rich peptides exclusively present in the saliva of higher primates. In this study, we explored the effects of Hsts on…”
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Lactoferrin Disaggregates Pneumococcal Biofilms and Inhibits Acquisition of Resistance Through Its DNase Activity
Published in Frontiers in microbiology (18-10-2019)“…Streptococcus pneumoniae colonizes the upper airways of children and the elderly. Colonization progresses to persistent carriage when S. pneumoniae forms…”
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Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay
Published in The FASEB journal (01-11-2008)“…Wounds in the oral cavity heal much faster than skin lesions. Among other factors, saliva is generally assumed to be of relevance to this feature. Rodent…”
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Survival of the Halophilic Archaeon Halovarius luteus after Desiccation, Simulated Martian UV Radiation and Vacuum in Comparison to Bacillus atrophaeus
Published in Origins of life and evolution of biospheres (01-12-2020)“…Extraterrestrial environments influence the biochemistry of organisms through a variety of factors, including high levels of radiation and vacuum, temperature…”
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Sortase A as a tool for high‐yield histatin cyclization
Published in The FASEB journal (01-08-2011)“…ABSTRACT Cyclic peptides are highly valued tools in biomedical research. In many cases, they show higher receptor affinity, enhanced biological activity, and…”
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Bovine Lactoferrin and Lactoferrin-Derived Peptides Inhibit the Growth of Vibrio cholerae and Other Vibrio species
Published in Frontiers in microbiology (11-01-2018)“…is a genus of Gram-negative bacteria, some of which can cause serious infectious diseases. Vibrio infections are associated with the consumption of…”
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GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1
Published in International journal of oral science (15-08-2022)“…Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic activity. We…”
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The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability
Published in PloS one (28-03-2016)“…Chronic ulcers represent a major health burden in our society. Despite many available therapies, a large number of ulcers do not heal. Protein based therapies…”
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