Search Results - "Nazir, Majid"
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Synthesis of Bi-heterocyclic Sulfonamides as Tyrosinase Inhibitors: Lineweaver-Burk Plot Evaluation and Computational Ascriptions
Published in Acta chimica Slovenica (01-06-2020)“…The designed bi-heterocyclic sulfonamides were synthesized through a two-step protocol and their structures were ascertained by spectral techniques including…”
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Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
Published in Journal of molecular structure (15-02-2025)“…•Designing of Indole-Phenyl-1,2,4-Triazole Bi-Heterocyclic.•Determining of In-vitro elastase inhibitory potential and kinetics.•Establishing the…”
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3
Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors
Published in Journal of molecular structure (15-01-2025)“…•Designing of indole-N-phenyltriazole hybrids.•Determining of In-vitro Alkaline phosphatase inhibitory potential and kinetics.•Establishing the…”
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4
New indole based hybrid oxadiazole scaffolds with N-substituted acetamides: As potent anti-diabetic agents
Published in Bioorganic chemistry (01-12-2018)“…[Display omitted] •Synthesis of new indole based hybrid oxadiazole scaffolds with N-substituted acetamides by multiple chemical transformations.•Structural…”
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Multi-step synthesis of indole-N-ethyltriazole hybrids amalgamated with N-arylated ethanamides: structure-activity relationship and mechanistic explorations through tyrosinase inhibition, kinetics and computational ascriptions
Published in Journal of molecular structure (05-08-2022)“…•Designing of indole-N-ethyltriazole hybrids amalgamated with N-arylated ethanamides as tyrosinase inhibitors•Ascertaining of in vitro inhibitory potential,…”
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6
Synthesis of promising antibacterial and antifungal agents: 2-[[acetamides
Published in Pakistan journal of pharmaceutical sciences (01-09-2020)“…In the presented work, 2,3-dihydro-l,4-benzodioxin-6-amine (1) was reacted with 4-chlorobenzenesulfonyl chloride (2) in presence of aqueous basic aqueous…”
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REPORT - Synthesis of promising antibacterial and antifungal agents: 2-[[(4-Chlorophenyl)sulfonyl](2,3-dihydro-1,4-benzodioxin-6-yl)amino]-N-(un/substituted-phenyl)acetamides
Published in Pakistan journal of pharmaceutical sciences (01-09-2020)“…In the presented work, 2,3-dihydro-1,4-benzodioxin-6-amine (1) was reacted with 4-chlorobenzenesulfonyl chloride (2) in presence of aqueous basic aqueous…”
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8
Novel indole based hybrid oxadiazole scaffolds with N -(substituted-phenyl)butanamides: synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
Published in RSC advances (01-01-2018)“…In the study presented herein, 4-(1 -indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1 -indol-3-yl)butanoate (2),…”
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Convergent synthesis, free radical scavenging, Lineweaver‐Burk plot exploration, hemolysis and in silico study of novel indole‐phenyltriazole hybrid bearing acetamides as potent urease inhibitors
Published in Journal of heterocyclic chemistry (01-07-2020)“…In the current paper, through a convergent multi‐step approach, a library of novel indole‐phenyltriazole hybrids containing an amide moiety (9a‐k) was…”
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Synthesis, Antioxidant and In-Silico Studies of Potent Urease Inhibitors: N-(4-{[(4-Methoxyphenethyl)-(substituted)amino]sulfonyl}phenyl)acetamides
Published in Drug research (01-02-2019)“…In this study, a new series of sulfonamides derivatives was synthesized and their inhibitory effects on DPPH and jack bean urease were evaluated. The in silico…”
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Bi‐heterocyclic benzamides as alkaline phosphatase inhibitors: Mechanistic comprehensions through kinetics and computational approaches
Published in Archiv der Pharmazie (Weinheim) (01-03-2019)“…Novel bi‐heterocyclic benzamides were synthesized by sequentially converting 4‐(1H‐indol‐3‐yl)butanoic acid (1) into ethyl 4‐(1H‐indol‐3‐yl)butanoate (2),…”
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Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity
Published in Pakistan journal of pharmaceutical sciences (01-11-2019)“…In the study presented here, the nucleophilic substitution reaction of 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazol-2-ylhydrosulfide was carried out with…”
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Novel indole based hybrid oxadiazole scaffolds with N-(substituted-phenyl)butanamides: synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ra04987d
Published 19-07-2018“…In the study presented herein, 4-(1 H -indol-3-yl)butanoic acid ( 1 ) was sequentially transformed in the first phase into ethyl 4-(1 H -indol-3-yl)butanoate (…”
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