Search Results - "Nazet, Ute"
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Housekeeping gene validation for RT-qPCR studies on synovial fibroblasts derived from healthy and osteoarthritic patients with focus on mechanical loading
Published in PloS one (06-12-2019)“…Selection of appropriate housekeeping genes is essential for the validity of data normalization in reverse transcription quantitative PCR (RT-qPCR). Synovial…”
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Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis
Published in International journal of molecular sciences (30-01-2019)“…Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive…”
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Early OA Stage Like Response Occurs after Dynamic Stretching of Human Synovial Fibroblasts
Published in International journal of molecular sciences (29-05-2020)“…As events triggering early osteoarthritis onset can be related to mechanical stress and proinflammatory signaling, we investigated the effect of different…”
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Effects of Compressive and Tensile Strain on Macrophages during Simulated Orthodontic Tooth Movement
Published in Mediators of inflammation (2020)“…During orthodontic tooth movement (OTM) to therapeutically correct the position of misaligned teeth, thus improving oral health and quality of life,…”
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Mechanical Stress Induces Sodium Entry and Osmoprotective Responses in Murine Synovial Fibroblasts
Published in Cells (Basel, Switzerland) (01-03-2024)“…Osteoarthritis (OA) is a multifactorial disease depending on molecular, genetic, and environmental factors like mechanical strain. Next to the cartilage and…”
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The role of 25-hydroxyvitamin-D3 and vitamin D receptor gene in human periodontal ligament fibroblasts as response to orthodontic compressive strain: an in vitro study
Published in BMC oral health (06-08-2021)“…This study aimed to investigate, if different physiological concentrations of vitamin D (25(OH)D ) and single nucleotide polymorphisms in vitamin D receptor…”
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Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity
Published in International journal of molecular sciences (09-01-2021)“…Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed…”
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Effect of genetic polymorphisms rs2301113 and rs2057482 in the expression of HIF-1α protein in periodontal ligament fibroblasts subjected to compressive force
Published in Journal of applied oral science (01-01-2023)“…Many genes and signaling molecules are involved in orthodontic tooth movement, with mechanically and hypoxically stabilized HIF-1α having been shown to play a…”
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Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint
Published in Cells (Basel, Switzerland) (01-02-2021)“…Genetic predisposition, traumatic events, or excessive mechanical exposure provoke arthritic changes in the temporomandibular joint (TMJ). We analysed the…”
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Simplified method for applying static isotropic tensile strain in cell culture experiments with identification of valid RT-qPCR reference genes for PDL fibroblasts
Published in European journal of orthodontics (11-09-2020)“…Periodontal ligament fibroblasts (PDLF) play an important mediating role in orthodontic tooth movement expressing various cytokines, when exposed to…”
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Sodium‐chloride‐induced effects on the expression profile of human periodontal ligament fibroblasts with focus on simulated orthodontic tooth movement
Published in European journal of oral sciences (01-10-2019)“…Increased salt (NaCl) consumption triggers chronic diseases such as hypertension or osteopenia. Its impact on orthodontic tooth movement and periodontitis,…”
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Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress
Published in Journal of orofacial orthopedics (01-11-2022)“…Purpose Apart from other risk factors, mechanical stress on joints can promote the development of osteoarthritis (OA), which can also affect the…”
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Effects of sodium chloride on the gene expression profile of periodontal ligament fibroblasts during tensile strain
Published in Journal of orofacial orthopedics (01-09-2020)“…Purpose During orthodontic tooth movement, pressure and tension zones develop in the periodontal ligament, and periodontal ligament fibroblasts (PDLF) become…”
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