Search Results - "Nazareth, Deborah"

Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation by Cabanes-Creus, Marti, Liao, Sophia H. Y., Gale Navarro, Renina, Knight, Maddison, Nazareth, Deborah, Lau, Ngee-Soon, Ly, Mark, Zhu, Erhua, Roca-Pinilla, Ramon, Bugallo Delgado, Ricardo, Vicente, Ana F., Baltazar, Grober, Westhaus, Adrian, Merjane, Jessica, Crawford, Michael, McCaughan, Geoffrey W., Unzu, Carmen, González-Aseguinolaza, Gloria, Alexander, Ian E., Pulitano, Carlo, Lisowski, Leszek

“…Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of…”
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Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer by Nazareth, Deborah, Jones, Mathew Jk, Gabrielli, Brian

“…The poor selectivity of standard cytotoxic chemotherapy regimens causes severe side-effects in patients and reduces the quality of life during treatment…”
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Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition by Vora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel AJ, Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew JK, Gabrielli, Brian

“…Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human…”
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Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine by Oo, Zay Yar, Proctor, Martina, Stevenson, Alexander J., Nazareth, Deborah, Fernando, Madushan, Daignault, Sheena M., Lanagan, Catherine, Walpole, Sebastian, Bonazzi, Vanessa, Škalamera, Dubravka, Snell, Cameron, Haass, Nikolas K., Larsen, Jill E., Gabrielli, Brian

“…Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block…”
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AAVolve: Concatenated long-read deep sequencing enables whole capsid tracking during shuffled AAV library selection by Scott, Suzanne, Westhaus, Adrian, Nazareth, Deborah, Cabanes-Creus, Marti, Navarro, Renina Gale, Chandra, Deborah, Zhu, Erhua, Venkateswaran, Aravind, Alexander, Ian E., Bauer, Denis C., Wilson, Laurence O.W., Lisowski, Leszek

“…Gene therapies using recombinant adeno-associated virus (AAV) vectors have demonstrated considerable clinical success in the treatment of genetic disorders…”
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Novel AAV variants with improved tropism for human Schwann cells by Drouyer, Matthieu, Chu, Tak-Ho, Labit, Elodie, Haase, Florencia, Navarro, Renina Gale, Nazareth, Deborah, Rosin, Nicole, Merjane, Jessica, Scott, Suzanne, Cabanes-Creus, Marti, Westhaus, Adrian, Zhu, Erhua, Midha, Rajiv, Alexander, Ian E., Biernaskie, Jeff, Ginn, Samantha L., Lisowski, Leszek

“…Gene therapies and associated technologies are transforming biomedical research and enabling novel therapeutic options for patients living with debilitating…”
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Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice by Drouyer, Matthieu, Merjane, Jessica, Nazareth, Deborah, Knight, Maddison, Scott, Suzanne, Liao, Sophia H Y, Ginn, Samantha L, Zhu, Erhua, Alexander, Ian E, Lisowski, Leszek

“…Directed evolution of natural AAV9 using peptide display libraries have been widely used in the search for an optimal recombinant AAV (rAAV) for transgene…”
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Abstract 1236: Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo by Oo, Zay Yar, Proctor, Martina, Stevenson, Alex, Nazareth, Deborah, Larsen, Jill, Haass, Nikolas, Gabrielli, Brian G.

“…Abstract Background: Lung cancer and melanoma are responsible for almost 25% of cancer deaths in Australia. Despite recent progress with targeted and…”
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Abstract A060: Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress by Andrews, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Ehmann, Anna, Hooper, John, McMillan, Nigel, Gabrielli, Brian

“…Abstract Aurora B kinase has a major role in regulating progression through mitosis and partitioning the replicated genome at exit from mitosis and…”
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