The possible antioxidant capabilities of formononetin in guarding against streptozotocin-induced diabetic nephropathy in rats

The possible antioxidant capabilities of formononetin in guarding against streptozotocin-induced diabetic nephropathy in rats

Background Oxidative stress has been considered as a contributory aspect for major complications of diabetes mellitus consisting of diabetic nephropathy. This study aimed to examine the therapeutic effect of formononetin in streptozotocin (STZ)-induced diabetic nephropathy through measuring biochemi...

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Bibliographic Details
Published in:Future journal of pharmaceutical sciences Vol. 6; no. 1; pp. 53 - 9
Main Authors: Jain, Pankaj G., Nayse, Priti G., Patil, Dipali J., Shinde, Sachin D., Surana, Sanjay J.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 12-08-2020
Springer Nature B.V
SpringerOpen
Subjects:
Animals
Antioxidant activity
Creatinine
Diabetes
Diabetic nephropathy
Drug dosages
Estrogens
Formononetin
Glucose
Hyperglycemia
Kidneys
Kinases
Lettuce
Medicine
Medicine & Public Health
Oxidative stress
Pharmaceutical sciences
Tumor necrosis factor-TNF
Urine
Mumbai India
India
Oxidative stress
Diabetic nephropathy
Formononetin
Antioxidant activity
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Summary:Background Oxidative stress has been considered as a contributory aspect for major complications of diabetes mellitus consisting of diabetic nephropathy. This study aimed to examine the therapeutic effect of formononetin in streptozotocin (STZ)-induced diabetic nephropathy through measuring biochemical parameters, oxidative indicators, and histopathological examination of renal tissues . Results Administration of a dose of STZ (55 mg/kg of body weight) intraperitoneal induced diabetic nephropathy in rats as indicated by an increase in serum glucose, creatinine, triglyceride, cholesterol, and BUN levels related to the depletion of serum albumin level. Besides, STZ treatment led to the depletion of antioxidant enzymes together with superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). Administration of formononetin at the dose of 10, 20, and 40 mg/kg extensively decreased biochemical parameters with a rise in serum albumin level. Formononetin was observed to improved antioxidant enzyme ranges and offered protection against lipid peroxidation (LPO). STZ administered rats show an elevated level of TNF-α and IL-6. Meanwhile, formononetin-treated rats inhibited the elevated level of cytokine. Conclusion This study concluded that formononetin may additionally modulate oxidative stress and protected renal tissues from STZ injury. It also showed improvement in renal histopathological architecture in STZ-induced diabetic nephropathy.
ISSN:2314-7253
2314-7245
2314-7253
DOI:10.1186/s43094-020-00071-9