Search Results - "Naylor, P H"

Immunotherapy for hepatitis B in the direct acting antiviral era: Reevaluating the thymosin [alpha]1 efficacy trials in the light of a combination therapy approach by Naylor, P H, Mutchnick, M G

“…Summary Hepatitis B virus (HBV) causes both acute and chronic hepatitis and infects large numbers of individuals worldwide. Unfortunately, prediction of…”
Get full text

Immunotherapy for hepatitis B in the direct acting antiviral era: Reevaluating the thymosin α1 efficacy trials in the light of a combination therapy approach by Naylor, P. H., Mutchnick, M. G.

“…Summary Hepatitis B virus (HBV) causes both acute and chronic hepatitis and infects large numbers of individuals worldwide. Unfortunately, prediction of…”
Get full text

African Americans with genotype 1 treated with interferon for chronic hepatitis C have a lower end of treatment response than Caucasians by Kinzie, J. L., Naylor, P. H., Nathani, M. G., Peleman, R. R., Ehrinpreis, M. N., Lybik, M., Turner, J. R., Janisse, J. J., Massanari, M., Mutchnick, M. G.

“…African Americans as a group have a higher incidence of chronic hepatitis C (CHC) than Caucasians but are often under‐represented in clinical trials used to…”
Get full text

Cellular Levels of Thymosin Immunoreactive Peptides are Linked to Proliferative Events: Evidence for a Nuclear Site of Action by Conteas, C. N., Mutchnick, M. G., Palmer, K. C., Weller, F. E., Luk, G. D., Naylor, P. H., Erdos, M. E., Goldstein, A. L., Panneerselvam, C., Horecker, B. L.

“…Thymosin α1(Tα1), the N-terminal 28-amino acid fragment of prothymosin α (ProTα), and ProTα, although originally isolated from whole thymus extracts, are also…”
Get full text

HGP-30, A Synthetic Analogue of Human Immunodeficiency Virus (HIV) p17, is a Target for Cytotoxic Lymphocytes in HIV-Infected Individuals by Achour, Ammar, Picard, Odile, Zagury, Daniel, Sarin, Prem S., Gallo, Robert C., Naylor, Paul H., Goldstein, Allan L.

“…Evaluation of the immune response of individuals exposed to human immunodeficiency virus (HIV) is an important component of any plan designed to lead toward…”
Get full text

Adjuvant properties of montanide CSA 720 with a recombinant HIV P17 gag protein and synthetic peptide antigens by Kirkley, J E, Goldstein, A L, Naylor, P H

“…The adjuvant properties of Montanide CSA 720 were assessed in a comparison with alum. BALB/c mice were immunized with recombinant HIV-1 gag protein p17…”
Get more information

Human immunodeficiency virus contains an epitope immunoreactive with thymosin alpha 1 and the 30-amino acid synthetic p17 group-specific antigen peptide HGP-30 by Naylor, P H, Naylor, C W, Badamchian, M, Wada, S, Goldstein, A L, Wang, S S, Sun, D K, Thornton, A H, Sarin, P S

“…We have reported that an antiserum prepared against thymosin alpha 1 [which shares a region of homology with the p17 protein of the acquired immunodeficiency…”
Get full text

HIV-1 p17 synthetic peptide vaccine HGP-30: induction of immune response in human subjects and preliminary evidence of protection against HIV challenge in SCID mice by Sarin, P S, Mora, C A, Naylor, P H, Markham, R, Schwartz, D, Kahn, J, Heseltine, P, Gazzard, B, Youle, M, Rios, A

“…An HIV-1 p17 subunit vaccine, HGP-30, was evaluated in 38 HIV-1 seronegative individuals in phase I clinical trials in U.K. and U.S.A. The vaccine preparation…”
Get more information

Low thymosin alpha-1 concentrations in patients chronically infected with the hepatitis B virus by Sherman, K E, Jones, C C, Goldstein, A L, Naylor, P H

“…Serum concentrations of thymosin alpha-1 (TA-1), an immunoregulatory peptide, were assayed in patients with chronic hepatitis B infection and volunteer blood…”
Get more information

A phase I study of HGP-30, a 30 amino acid subunit of the human immunodeficiency virus (HIV) p17 synthetic peptide analogue sub-unit vaccine in seronegative subjects by Kahn, J O, Stites, D P, Scillian, J, Murcar, N, Stryker, R, Volberding, P A, Naylor, P H, Goldstein, A L, Sarin, P S, Simmon, V F

“…HGP-30-KLH vaccine in alum at doses of 10, 25, 50, and 100 micrograms/kg administered intramuscularly at weeks 0, 4, and 10 appear well-tolerated clinically…”
Get more information

Specific antibody responses to synthetic peptides of HIV-1 p17 correlate with different stages of HIV-1 infection by Jiang, J D, Chu, F N, Naylor, P H, Kirkley, J E, Mandeli, J, Wallace, J I, Sarin, P S, Goldstein, A L, Holland, J F, Bekesi, J G

“…Antibodies were determined against five synthetic peptides (epitopes) of HIV-1 p17 in the sera of an immunologically and clinically well-characterized cohort…”
Get more information

Effects of PCB (Aroclor 1254) on non-specific immune parameters in rhesus (Macaca mulatta) monkeys by Tryphonas, H, Luster, M I, White, Jr, K L, Naylor, P H, Erdos, M R, Burleson, G R, Germolec, D, Hodgen, M, Hayward, S, Arnold, D L

“…The effects of low level, chronic polychlorinated biphenyl--Aroclor 1254--(PCB) exposure were investigated on non-specific immune parameters in female rhesus…”
Get more information

Elevated thymosin alpha I levels in Brazilian pemphigus foliaceus by Roscoe, J T, Naylor, P H, Diaz, L A, Labib, R S, Patel, H P, Goldstein, A L, Sampaio, S A, Anhalt, G J

“…Levels of thymosin alpha I in the sera of 37 patients with Brazilian pemphigus foliaceus (BPF) were measured using a competitive binding radioimmunoassay. The…”
Get more information

Changes in circulating levels of neuroendocrine and thymic hormones during aging in rats: a correlation study by Goya, R G, Naylor, P H, Goldstein, A L, Meites, J

“…It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing…”
Get more information

Thymosin alpha 1 in milk specimens from Guatemalan women by Cruz, J R, Naylor, P H, Goldstein, A L

“…Thymosin alpha 1 was determined in milk samples obtained from 67 Guatemalan women 5 days, and 1-3 and 6-18 months postpartum. All the specimens collected 5…”
Get more information

Clonal growth inhibition as a bioassay for thymosin alpha1: inactivation of Talpha1 by trifluroacetic acid by Bianco-Batlles, D, Naylor, C W, Moshier, J A, Dosescu, J, Naylor, P H

“…Thymosin alpha1 (Talpha1) is an immune response modifying peptide isolated from thymus tissue. The synthetic peptide has been evaluated in clinical trials as…”
Get more information

Cell-mediated immunity against HGP-30, a group-specific peptide of HIV p17 in individuals infected with the AIDS virus by Willer, A, Achour, A, Mbika, J P, Laaroubi, K, Lachgar, A, Nihrane, A, Picard, O, Naylor, P H, Sarin, P S, Goldstein, A L

“…HGP-30, the synthetic peptide analogue and active component in an HIV-1 (human immunodeficiency virus, type 1) p 17 core-based experimental vaccine, has…”
Get more information

Human T cell leukemia virus type III antibody, lymphadenopathy, and acquired immune deficiency syndrome in hemophiliac subjects. Results of a prospective study by Kreiss, J K, Kitchen, L W, Prince, H E, Kasper, C K, Goldstein, A L, Naylor, P H, Preble, O, Stewart, J A, Essex, M

“…A cohort of 63 hemophiliac subjects was followed for clinical and immunologic abnormalities related to the acquired immune deficiency syndrome (AIDS). When…”
Get more information

Effect of Peptide-Carrier Coupling on Peptide-Specific Immune Responses by Kirkley, Janet E., Goldstein, Allan L., Naylor, Paul H.

“…Synthetic peptides are covalently linked to immunogenic carrier proteins to enhance the ami-peptide immune response.To investigate whether the method of…”
Get full text

Micro ELISA for measurement of parathymosin alpha utilizing a monoclonal antibody by Wada, S, Naylor, P H, Naylor, C W, Goldstein, A L

“…A monoclonal antibody to the non-thymosin alpha 1 overlapping sequence of parathymosin alpha was used to develop a micro ELISA to measure parathymosin alpha…”
Get more information