Search Results - "Naylor, Jacqueline"

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition by Kaneko, Kentaro, Fu, Yukiko, Lin, Hsiao-Yun, Cordonier, Elizabeth L, Mo, Qianxing, Gao, Yong, Yao, Ting, Naylor, Jacqueline, Howard, Victor, Saito, Kenji, Xu, Pingwen, Chen, Siyu S, Chen, Miao-Hsueh, Xu, Yong, Williams, Kevin W, Ravn, Peter, Fukuda, Makoto

“…Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here,…”
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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis by Boland, Michelle L., Laker, Rhianna C., Mather, Karly, Nawrocki, Arkadiusz, Oldham, Stephanie, Boland, Brandon B., Lewis, Hilary, Conway, James, Naylor, Jacqueline, Guionaud, Silvia, Feigh, Michael, Veidal, Sanne S., Lantier, Louise, McGuinness, Owen P., Grimsby, Joseph, Rondinone, Cristina M., Jermutus, Lutz, Larsen, Martin R., Trevaskis, James L., Rhodes, Christopher J.

“…Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1…”
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Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease by Pechenov, Sergei, Revell, Jefferson, Will, Sarah, Naylor, Jacqueline, Tyagi, Puneet, Patel, Chandresh, Liang, Lihuan, Tseng, Leo, Huang, Yue, Rosenbaum, Anton I., Balic, Kemal, Konkar, Anish, Grimsby, Joseph, Subramony, J. Anand

“…Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience,…”
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Pharmacological antagonism of the incretin system protects against diet-induced obesity by Svendsen, Berit, Capozzi, Megan E., Nui, Jingjing, Hannou, Sarah A., Finan, Brian, Naylor, Jacqueline, Ravn, Peter, D'Alessio, David A., Campbell, Jonathan E.

“…Glucose-dependent insulinotropic polypeptide is an intestinally derived hormone that is essential for normal metabolic regulation. Loss of the GIP receptor…”
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Establishing a Relationship between In Vitro Potency in Cell-Based Assays and Clinical Efficacious Concentrations for Approved GLP-1 Receptor Agonists by Boianelli, Alessandro, Nordell, Pär, Earl, Joseph, Naylor, Jacqueline, Hornigold, David, Jansson Löfmark, Rasmus, Sundqvist, Monika

“…Glucagon-like peptide-1 receptor agonists (GLP-1RAs) play an important role in the treatment of type 2 diabetes (T2D) and obesity. The relationship between…”
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TRPC channel activation by extracellular thioredoxin by Beech, David J, Xu, Shang-Zhong, Sukumar, Piruthivi, Zeng, Fanning, Li, Jing, Jairaman, Amit, English, Anne, Naylor, Jacqueline, Ciurtin, Coziana, Majeed, Yasser, Milligan, Carol J, Bahnasi, Yahya M, Al-Shawaf, Eman, Porter, Karen E, Jiang, Lin-Hua, Emery, Paul, Sivaprasadarao, Asipu

“…Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively…”
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Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly by Ouberai, Myriam M., Dos Santos, Ana L. Gomes, Kinna, Sonja, Madalli, Shimona, Hornigold, David C., Baker, David, Naylor, Jacqueline, Sheldrake, Laura, Corkill, Dominic J., Hood, John, Vicini, Paolo, Uddin, Shahid, Bishop, Steven, Varley, Paul G., Welland, Mark E.

“…The use of peptides as therapeutic agents is undergoing a renaissance with the expectation of new drugs with enhanced levels of efficacy and safety. Their…”
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Natural and synthetic flavonoid modulation of TRPC5 channels by Naylor, Jacqueline, Minard, Aisling, Gaunt, Hannah J, Amer, Mohamed S, Wilson, Lesley A, Migliore, Marco, Cheung, Sin Y, Rubaiy, Hussein N, Blythe, Nicola M, Musialowski, Katie E, Ludlow, Melanie J, Evans, William D, Green, Ben L, Yang, Hongjun, You, Yun, Li, Jing, Fishwick, Colin W G, Muraki, Katsuhiko, Beech, David J, Bon, Robin S

“…Background and Purpose The TRPC5 proteins assemble to create calcium‐permeable, non‐selective, cationic channels. We sought novel modulators of these channels…”
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Stimulating intestinal GIP release reduces food intake and body weight in mice by Lewis, Jo E., Nuzzaci, Danae, James-Okoro, Paula-Peace, Montaner, Mireia, O'Flaherty, Elisabeth, Darwish, Tamana, Hayashi, Marito, Liberles, Stephen D., Hornigold, David, Naylor, Jacqueline, Baker, David, Gribble, Fiona M., Reimann, Frank

“…Glucose dependent insulinotropic polypeptide (GIP) is well established as an incretin hormone, boosting glucose-dependent insulin secretion. However, whilst…”
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Self-assembled GLP-1/glucagon peptide nanofibrils prolong inhibition of food intake by Ouberai, Myriam M, Gomes Dos Santos, Ana L, Kinna, Sonja, Hornigold, David C, Baker, David, Naylor, Jacqueline, Liang, Lihuan, Corkill, Dominic J, Welland, Mark E

“…Oxyntomodulin (Oxm) hormone peptide has a number of beneficial effects on nutrition and metabolism including increased energy expenditure and reduced body…”
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Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels by Majeed, Yasser, Bahnasi, Yahya, Seymour, Victoria A L, Wilson, Lesley A, Milligan, Carol J, Agarwal, Anil K, Sukumar, Piruthivi, Naylor, Jacqueline, Beech, David J

“…The aim of this study was to generate new insight into chemical regulation of transient receptor potential (TRP) channels with relevance to glucose homeostasis…”
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Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma‐1 receptor ligands by Amer, Mohamed S, McKeown, Lynn, Tumova, Sarka, Liu, Ruifeng, Seymour, Victoria AL, Wilson, Lesley A, Naylor, Jacqueline, Greenhalgh, Katriona, Hou, Bing, Majeed, Yasser, Turner, Paul, Sedo, Alicia, O'Regan, David J, Li, Jing, Bon, Robin S, Porter, Karen E, Beech, David J

“…Background and Purpose The Sigma‐1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its…”
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A Sphingosine-1–Phosphate–Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility by Xu, Shang-Zhong, Muraki, Katsuhiko, Zeng, Fanning, Li, Jing, Sukumar, Piruthivi, Shah, Samir, Dedman, Alexandra M, Flemming, Philippa K, McHugh, Damian, Naylor, Jacqueline, Cheong, Alex, Bateson, Alan N, Munsch, Christopher M, Porter, Karen E, Beech, David J

“…In a screen of potential lipid regulators of transient receptor potential (TRP) channels, we identified sphingosine-1–phosphate (S1P) as an activator of TRPC5…”
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Short-Term Stimulation of Calcium-Permeable Transient Receptor Potential Canonical 5-Containing Channels by Oxidized Phospholipids by AL-Shawaf, Eman, Naylor, Jacqueline, Taylor, Hilary, Riches, Kirsten, Milligan, Carol J, OʼRegan, David, Porter, Karen E, Li, Jing, Beech, David J

“…OBJECTIVE—To determine whether calcium-permeable channels are targets for the oxidized phospholipids1-palmitoyl-2-glutaroyl-phosphatidylcholine (PGPC) and…”
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Robotic multiwell planar patch-clamp for native and primary mammalian cells by Beech, David J, Milligan, Carol J, Li, Jing, Sukumar, Piruthivi, Majeed, Yasser, Dallas, Mark L, English, Anne, Emery, Paul, Porter, Karen E, Smith, Andrew M, McFadzean, Ian, Beccano-Kelly, Dayne, Bahnasi, Yahya, Cheong, Alex, Naylor, Jacqueline, Zeng, Fanning, Liu, Xing, Gamper, Nikita, Jiang, Lin-Hua, Pearson, Hugh A, Peers, Chris, Robertson, Brian

“…Robotic multiwell planar patch-clamp has become common in drug development and safety programs because it enables efficient and systematic testing of compounds…”
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Sensing of Lysophospholipids by TRPC5 Calcium Channel by Flemming, Philippa K., Dedman, Alexandra M., Xu, Shang-Zhong, Li, Jing, Zeng, Fanning, Naylor, Jacqueline, Benham, Christopher D., Bateson, Alan N., Muraki, Katsuhiko, Beech, David J.

“…TRPC calcium channels are emerging as a ubiquitous feature of vertebrate cells, but understanding of them is hampered by limited knowledge of the mechanisms of…”
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Transcriptomics reveal the genetic coordination of early defense to Armillaria root rot (ARR) in Prunus spp by Cai, Lichun, Adelberg, Jeffrey, Naylor-Adelberg, Jacqueline, Schnabel, Guido, Calle, Alejandro, Li, Zhigang, Reighard, Gregory, Gasic, Ksenija, Saski, Christopher A

“…root rot (ARR) poses a significant threat to the long-term productivity of stone-fruit and nut crops in the predominant production area of the United States…”
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GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels by AL-Shawaf, Eman, Tumova, Sarka, Naylor, Jacqueline, Majeed, Yasser, Li, Jing, Beech, David J

“…Abstract The Transient Receptor Potential Canonical 5 (TRPC5) protein forms calcium-permeable cationic channels that are stimulated by G protein-coupled…”
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TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan by Ciurtin, Coziana, Majeed, Yasser, Naylor, Jacqueline, Sukumar, Piruthivi, English, Anne A, Emery, Paul, Beech, David J

“…Calcium-permeable channels are known to have roles in many mammalian cell types but the expression and contribution of such ion channels in synovial cells is…”
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Randomised, phase 1, dose-finding study of MEDI4166, a PCSK9 antibody and GLP-1 analogue fusion molecule, in overweight or obese patients with type 2 diabetes mellitus by Jain, Meena, Carlson, Glenn, Cook, William, Morrow, Linda, Petrone, Marcella, White, Nicholas E., Wang, Tao, Naylor, Jacqueline, Ambery, Philip, Lee, Charles, Hirshberg, Boaz

“…Aims/hypothesis Cardiovascular disease is the leading cause of morbidity and mortality in people with type 2 diabetes. MEDI4166 is a proprotein convertase…”
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