Search Results - "Naylor, E M"

Synthesis and regioselective alkylation of 1,6- and 1,7-naphthyridines by Colandrea, Vincent J, Naylor, Elizabeth M

“…A regioselective alkylation of naphthyridines 4a– d, through the action of ethylchloroformate and benzylstannane 5, afforded the benzyl substituted…”
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A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist by CHAKRAVARTY, P. K, NAYLOR, E. M, SCHORN, T. W, SCHAFFER, L. W, BROTEN, T. P, SIEGL, P. K. S, PATCHETT, A. A, GREENLEE, W. J, CHEN, A, CHANG, R. S. L, TSING-BAU CHEN, FAUST, K. A, LOTTI, V. J, KIVLIGHN, S. D, GABLE, R. A, ZINGARO, G. J

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Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity by Ashton, Wallace T, Chang, Linda L, Flanagan, Kelly L, Hutchins, Steven M, Naylor, Elizabeth M, Chakravarty, Prasun K, Patchett, Arthur A, Greenlee, William J, Chen, Tsing-Bau

“…Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the…”
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Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist by Williams, David L, Murphy, Kathryn L, Nolan, Nancy A, O'Brien, Julie A, Lis, Edward V, Pettibone, Douglas J, Clineschmidt, Bradley V, Krause, Stephen M, Veber, Daniel F, Naylor, Elizabeth M, Chakravarty, Prasun K, Walsh, Thomas F, Dhanoa, Dale M, Chent, Anna, Bagley, Scott W, Fitch, Kenneth J, Greenlee, William J

“…L-744,453 ((±)3-[4-(1-carboxy-1-(3,4-methylenedioxyphenyl)methoxy)-3,5-dipropylphenylmethyl]-3H-imidazo[4,5- c]pyridine) is an endothelin (ET) receptor…”
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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective β3 adrenergic receptor agonist antiobesity agents by BIFTU, T, FENG, D. D, FORREST, M. J, HOM, G. J, MACLNTYRE, D. E, STEARNS, R. A, STRADER, C. D, WYVRATT, M. J, FISHER, M. H, WEBER, A. E, LIANG, G.-B, KUO, H, XIAOXIA QIAN, NAYLOR, E. M, COLANDREA, V. J, CANDELORE, M. R, CASCIERI, M. A, COLWELL, L. F

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Human β3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides by NAYLOR, E. M, PARMEE, E. R, FORREST, M. J, HOM, G. J, MACINTYRE, D. E, STRADER, C. D, TOTA, L, WANG, P.-R, WYVRATT, M. J, FISHER, M. H, WEBER, A. E, COLANDREA, V. J, PERKINS, L, BROCKUNIER, L, CANDELORE, M. R, CASCIERI, M. A, COLWELL, L. F, LIPING DENG, FEENEY, W. P

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3-pyridylethanolamines : Potent and selective human β3 adrenergic receptor agonists by NAYLOR, E. M, COLANDREA, V. J, STRADER, C. D, TOTA, L, WANG, P.-R, WYVRATT, M. J, FISHER, M. H, WEBER, A. E, CANDELORE, M. R, CASCIERI, M. A, COLWELL, L. F, LIPING DENG, FEENEY, W. P, FORREST, M. J, HOM, G. J, MACINTYRE, D. E

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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents by Biftu, T, Feng, D D, Liang, G B, Kuo, H, Qian, X, Naylor, E M, Colandrea, V J, Candelore, M R, Cascieri, M A, Colwell, Jr, L F, Forrest, M J, Hom, G J, MacIntyre, D E, Stearns, R A, Strader, C D, Wyvratt, M J, Fisher, M H, Weber, A E

“…Benzyl and phenoxymethylene substituted oxadiazoles are potent and orally bioavailable beta3 adrenergic receptor (AR) agonists. The 4-trifluormethoxy…”
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Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides by Naylor, E M, Parmee, E R, Colandrea, V J, Perkins, L, Brockunier, L, Candelore, M R, Cascieri, M A, Colwell, Jr, L F, Deng, L, Feeney, W P, Forrest, M J, Hom, G J, MacIntyre, D E, Strader, C D, Tota, L, Wang, P R, Wyvratt, M J, Fisher, M H, Weber, A E

“…The cyclopentylpropylimidazolidinone L-766,892 is a potent beta3 AR agonist (EC50 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to…”
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Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides by Parmee, E R, Naylor, E M, Perkins, L, Colandrea, V J, Ok, H O, Candelore, M R, Cascieri, M A, Deng, L, Feeney, W P, Forrest, M J, Hom, G J, MacIntyre, D E, Miller, R R, Stearns, R A, Strader, C D, Tota, L, Wyvratt, M J, Fisher, M H, Weber, A E

“…Human beta3 adrenergic receptor agonists containing 5-membered ring ureas were shown to be potent partial agonists with excellent selectivity over beta1 and…”
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Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging by Hamill, T G, Burns, H D, Dannals, R F, Mathews, W B, Musachio, J L, Ravert, H T, Naylor, E M

“…[11C]L-159,884 ([11C] N-[[4'[(2-ethyl-5,7-dimethyl-3H- imidazo[4,5-b]pyridin-3-yl) methyl] [1,1'-biphenyl]-2-yl] sulfonyl]-4-methoxybenzamide) and…”
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Human β3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides by Parmee, Emma R., Naylor, Elizabeth M., Perkins, Leroy, Colandrea, Vincent J., Ok, Hyun O., Candelore, Mari R., Cascieri, Margaret A., Deng, Liping, Feeney, William P., Forrest, Michael J., Hom, Gary J., MacIntyre, D.Euan, Miller, Randall R., Stearns, Ralph A., Strader, Catherine D., Tota, Laurie, Wyvratt, Matthew J., Fisher, Michael H., Weber, Ann E.

“…Human β 3 adrenergic receptor agonists containing 5-membered ring ureas were shown to be potent partial agonists with excellent selectivity over β 1 and β 2…”
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3-pyridylethanolamines: Potent and selective human β 3 adrenergic receptor agonists by Naylor, Elizabeth M., Colandrea, Vincent J., Candelore, Mari R., Cascieri, Margaret A., Colwell, Lawrence F., Deng, Liping, Feeney, William P., Forrest, Michael J., Hom, Gary J., Euan MacIntyre, D., Strader, Catherine D., Tota, Laurie, Wang, Pei-Ran, Wyvratt, Matthew J., Fisher, Michael H., Weber, Ann E.

“…The 3-pyridylethanolamine L-757,793 is a potent β 3 AR agonist (EC 50 6.3 nM, 70% activation) with 1,300- and 500-fold selectivity over binding to the β 1 and…”
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In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996 by Kivlighn, S D, Zingaro, G J, Gabel, R A, Broten, T P, Schorn, T W, Schaffer, L W, Naylor, E M, Chakravarty, P K, Patchett, A A, Greenlee, W J

“…MK-996, N-(4'-(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl- methyl)1,1'-biphenyl-2-yl)-sulfonylbenzamide, is a potent, orally active, highly selective,…”
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Novel aspects of the chemistry of thioamides by Naylor, E M

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Jacob Handl (Gallus) by Naylor, Edward W.

“…A paper on Jacob Handl can hardly be called superfluous. There is very little about him or about his works in the usual English books of reference. The English…”
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Some Characteristics of Heinrich Schütz (1585-1672.) by Naylor, E. W.

“…It is twelve years since I read a paper before this Society; and circumstances have prevented me from attending the meetings as I should have wished. I am all…”
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