Search Results - "Naylor, David E."

Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus by Naylor, David E, Liu, Hantao, Niquet, Jerome, Wasterlain, Claude G

“…Abstract After 1 h of lithium-pilocarpine status epilepticus (SE), immunocytochemical labeling of NMDA receptor NR1 subunits reveals relocation of subunits…”
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In the fast lane: Receptor trafficking during status epilepticus by Naylor, David E.

“…Status epilepticus (SE) remains a significant cause of morbidity and mortality and often is refractory to standard first‐line treatments. A rapid loss of…”
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Introduction to the special issue on status epilepticus: neuronal injury, plasticity, and therapies; Celebrating the legacy of Dr. Claude G. Wasterlain by Engel Jr, Jerome, Moshé, Solomon L., Nehlig, Astrid, Fujikawa, Denson G., Sankar, Raman, Naylor, David E., Mazarati, Andrey M., Wasterlain, Claude G.

“…The main content is largely based on presentations given at the symposium Pathophysiology and Treatment of Status Epilepticus, held in honor of Claude at the…”
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Trafficking of GABAA Receptors, Loss of Inhibition, and a Mechanism for Pharmacoresistance in Status Epilepticus by Naylor, David E, Liu, Hantao, Wasterlain, Claude G

“…During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithiumpilocarpine-induced SE, our…”
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Glutamate and GABA in the balance: Convergent pathways sustain seizures during status epilepticus by Naylor, David E.

“…Summary Seizures rapidly become self‐sustaining and pharmacoresistant to benzodiazepines during status epilepticus (SE). A decrease in the number of…”
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Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus by Naylor, David E, Liu, Hantao, Wasterlain, Claude G

“…During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithiumpilocarpine-induced SE, our…”
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Trafficking of NMDA receptors during status epilepticus: Therapeutic implications by Wasterlain, Claude G., Naylor, David E., Liu, Hantao, Niquet, Jerome, Baldwin, Roger

“…Summary We used two models of status epilepticus (SE) to study trafficking of N‐methyl‐d‐aspartate (NMDA) receptors. SE is associated with increased surface…”
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Treating acute seizures with benzodiazepines: does seizure duration matter? by Naylor, David E.

“…Several clinical trials have shown improved seizure control and outcome by early initiation of treatment with benzodiazepines, before arrival in the emergency…”
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Rational polytherapy in the treatment of acute seizures and status epilepticus by Wasterlain, Claude G., Baldwin, Roger, Naylor, David E., Thompson, Kerry W., Suchomelova, Lucie, Niquet, Jerome

“…Summary We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure‐induced loss of synaptic…”
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Safety of laronidase delivered into the spinal canal for treatment of cervical stenosis in mucopolysaccharidosis I by Dickson, Patricia I., Kaitila, Ilkka, Harmatz, Paul, Mlikotic, Anton, Chen, Agnes H., Victoroff, Alla, Passage, Merry B., Madden, Jacqueline, Le, Steven Q., Naylor, David E.

“…Enzyme replacement therapy with laronidase (recombinant human alpha-l-iduronidase) is successfully used to treat patients with mucopolysaccharidosis type I…”
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Molecular basis of self‐sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited by Wasterlain, Claude G., Liu, Hantao, Naylor, David E., Thompson, Kerry W., Suchomelova, Lucy, Niquet, Jerome, Mazarati, Audrey M., Baldwin, Roger A.

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GABA Synapses and the Rapid Loss of Inhibition to Dentate Gyrus Granule Cells after Brief Perforant‐Path Stimulation by Naylor, David E., Wasterlain, Claude G.

“…Purpose: To study the pharmacologic and synaptic basis for the early loss of paired‐pulse inhibition that occurs in the perforant‐path stimulation model of…”
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Trafficking of GABA sub(A) Receptors, Loss of Inhibition, and a Mechanism for Pharmacoresistance in Status Epilepticus by Naylor, David E, Liu, Hantao, Wasterlain, Claude G

“…During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithiumpilocarpine-induced SE, our…”
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Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited: Proceedings of the Innsbruck Colloquium on Status Epilepticus, Innsbruck, Austria, April 2-5, 2009 by WASTERLAIN, Claude G, HANTAO LIU, NAYLOR, David E, THOMPSON, Kerry W, SUCHOMELOVA, Lucy, NIQUET, Jerome, MAZARATI, Audrey M, BALDWIN, Roger A

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Computer enhancement of scalp-sphenoidal ictal EEG in patients with complex partial seizures by Naylor, D E, Lieb, J P, Risinger, M

“…Color topographic maps of scalp/sphenoidal ictal EEG records were computer-generated in 5 patients with medically refractory complex partial seizures of…”
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