Comparison of Oocyte and Embryo Quality in Women with Polycystic Ovary Syndrome and the Control Group Candidate for In Vitro Fertilization and Intracytoplasmic Sperm Injection
Background: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy and one of the most common causes of female infertility. The primary oocyte quality has an utmost important effect on the survival of the embryo, as well as in the establishment and maintenance of pregnancy, fetus grow...
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| Published in: | Iranian journal of medical sciences Vol. 48; no. S1; p. 119 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
01-01-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Background: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy and one of the most common causes of female infertility. The primary oocyte quality has an utmost important effect on the survival of the embryo, as well as in the establishment and maintenance of pregnancy, fetus growth, and even in possible adulthood illnesses. Therefore, This study aimed to compare the oocyte and embryo quality between the PCOS women with the control group candidate for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods: The current study was designed in the prospective cohort format at the Milad Infertility Research Center and was conducted on 100 cases of infertile women with confirmed PCOS (case group) and the male factor (control group) as first IVF cycle candidates. Both groups underwent the ovary stimulation cycle and ICSI under the standard antagonist protocol. The collected data were then processed and analyzed using the SPSS software, version 16. Results: The mean age of study cases was 35[+ or -]3, and oocyte necrosis was the underlying pathological factor in both groups (28% and 26% in the PCOS and control groups, respectively). In addition, most embryones belonged to either grade 1 or 2 or were 8-cell embryos. Furthermore, the highest number of transferred embryos among the patients was related to the 8-cell and grade 1. The occurrences of biochemical pregnancy in the PCOS and control groups were up to 31.91% and 22%, respectively, leading to 72.73% and 60% childbirth in cases of both groups. Finally, there were no significant differences concerning the quality and the quantity of the embryones, the oocyte, the transferred embryo, the germinal vesicle oocytes, and the rate of pregnancy among the two groups (P>0.05). Conclusion: According to the results of the present study, no differences were found concerning the oocyte quality, embryo, and pregnancy rate between PCOS cases and any other patients requiring ICSI. Therefore, such cases can similarly benefit from ICSI methods as well. Keywords * Polycystic ovary syndrome * Intracytoplasmic * Sperm injections * Infertility, female * Pregnancy rate * Oocyte * Fertilization |
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| ISSN: | 0253-0716 |