Search Results - "Nayeem, Shahid M."

Z-Guggulsterone Is a Potential Lead Molecule of Dawa-ul-Kurkum against Hepatocellular Carcinoma by Gupta, Meenakshi, Ghufran, Shaikh Maryam, Kausar, Tasneem, Ali, Rafat, Biswas, Subhrajit, Nayeem, Shahid M., Ishrat, Romana, Ali, Sher, Ahmad, Ajaz, Rather, Irfan A., Sarwat, Maryam

“…An ancient saffron-based polyherbal formulation, Dawa-ul-Kurkum (DuK), has been used to treat liver ailments and other diseases and was recently evaluated for…”
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Effect of TMAO and Urea on Dimers and Tetramers of Amyloidogenic Heptapeptides (23FGAILSS29) by Khan, Ashma, Nayeem, Shahid M

“…Human islet amyloid polypeptide (hIAPP) (1–37) is an intrinsically disordered protein that is released with insulin by β-cells found in the pancreas. Under…”
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Effect of Urea, Arginine, and Ethanol Concentration on Aggregation of 179CVNITV184 Fragment of Sheep Prion Protein by Jahan, Ishrat, Nayeem, Shahid M

“…Understanding protein aggregation is of utmost importance as it is responsible for causing several neurodegenerative diseases and one of the serious…”
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Effect of Osmolytes on Conformational Behavior of Intrinsically Disordered Protein α-Synuclein by Jahan, Ishrat, Nayeem, Shahid M.

“…α-Synuclein is an intrinsically disordered protein whose function in a healthy brain is poorly understood. It is genetically and neuropathologically linked to…”
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Stability of the Aβ42 Peptide in Mixed Solutions of Denaturants and Proline by Khan, Ashma, Nayeem, Shahid M.

“…Amyloid β-peptide (Aβ) is responsible for the neuronal damage and death of a patient with Alzheimer’s disease (AD). Aβ42 oligomeric forms are dominant…”
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Biophysical insight into the binding mechanism of doxofylline to bovine serum albumin: An in vitro and in silico approach by Siddiqui, Sharmin, Ameen, Faisal, Kausar, Tasneem, Nayeem, Shahid M., Ur Rehman, Sayeed, Tabish, Mohammad

“…[Display omitted] •UV-visible and steady-state fluorescence demonstrated the static kind of quenching mechanism.•Doxofylline binding at the subdomain IB (site…”
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Conformational dynamics of superoxide dismutase (SOD1) in osmolytes: a molecular dynamics simulation study by Jahan, Ishrat, Nayeem, Shahid M

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the misfolding of Cu, Zn superoxide dismutase (SOD1). Several earlier…”
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Identification of small molecule inhibitors of ALK2: a virtual screening, density functional theory, and molecular dynamics simulations study by Kausar, Tasneem, Nayeem, Shahid M.

“…Bone morphogenetic proteins (BMPs) are a family of more than 30 ligands and several receptors, such as activin like kinases (ALKs) and bone morphogenetic…”
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Studying the interaction of scopolamine with calf-thymus DNA: An in-vitro and in-silico approach and genotoxicity by Ameen, Faisal, Siddiqui, Sharmin, Jahan, Ishrat, Nayeem, Shahid M., Rehman, Sayeed ur, Tabish, Mohammad

“…[Display omitted] •Scopolamine interacts with ct-DNA at its grooves.•Electrostatic interaction and van der Waals forces are the stabilizing…”
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Exploring the interaction of tepotinib with calf thymus DNA using molecular dynamics simulation and multispectroscopic techniques by Amir, Mohd, Aamir Qureshi, Mohd, Khan, Ashma, Nayeem, Shahid M, Ayoub Malik, Waseem, Javed, Saleem

“…In recent times, there has been a surge in the discovery of drugs that directly interact with DNA, influencing gene expression. As a result, understanding how…”
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Correlating interfacial water dynamics with protein-protein interaction in complex of GDF-5 and BMPRI receptors by Kausar, Tasneem, Nayeem, Shahid M.

“…GDF-5 mediated signal transduction regulating chondrogenesis and skeletogenesis involves three different type-I receptors viz. Act-RI, BMPRIA and BMPRIB…”
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In silico studies of the human IAPP in the presence of osmolytes by Khan, Ashma, Jahan, Ishrat, Nayeem, Shahid M.

“…The human islet amyloid polypeptide or amylin is secreted along with insulin by pancreatic islets. Under the drastic environmental conditions, amylin can…”
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Biophysical and biochemical studies on glycoxidatively modified human low density lipoprotein by Abidi, Minhal, Khan, M. Salman, Ahmad, Saheem, Kausar, Tasneem, Nayeem, Shahid M., Islam, Sidra, Ali, Asif, Alam, Khursheed, Moinuddin

“…Methylglyoxal (MGO), a reactive dicarbonyl metabolite is a potent arginine directed glycating agent which has implications for diabetes-related complications…”
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Stimulation of GMP formation in hGBP1 is mediated by W79 and its effect on the antiviral activity by Raninga, Nikunj, Nayeem, Shahid M., Gupta, Sowmiya, Mullick, Ranajoy, Pandita, Esha, Das, Saumitra, Deep, Shashank, Sau, Apurba Kumar

“…The underlying mechanism of assembly‐stimulated GMP formation by large GTPase hGBP1 is not fully clarified. Here, we suggest that after first phosphate…”
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Computational and physicochemical insight into 4-hydroxy-2-nonenal induced structural and functional perturbations in human low-density lipoprotein by Tufail, Neda, Abidi, Minhal, Warsi, Mohd Sharib, Kausar, Tasneem, Nayeem, Shahid M.

“…Lipid peroxidation (LPO) is a biological process that frequently occurs under physiological conditions. Undue oxidative stress increases the level of LPO;…”
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Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents by Manzoor, Shoaib, Almarghalani, Daniyah A., James, Antonisamy William, Raza, Md Kausar, Kausar, Tasneem, Nayeem, Shahid M., Hoda, Nasimul, Shah, Zahoor A.

“…Objective Neuroprotection is a precise target for the treatment of neurodegenerative diseases, ischemic stroke, and traumatic brain injury. Pyrimidine and its…”
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The inhibitory effect of Sunset Yellow on thermally induced Human Serum Albumin aggregates: Possible role in naturopathy by Mohammad Zakariya, Syed, Zaman, Masihuz, Nabi, Faisal, Moasfar Ali, Syed, Jahan, Ishrat, Nayeem, Shahid M., Khan, Rizwan Hasan

“…•Effect of SY over HSA in an in vitro manner was investigated.•HSA (15 μM) was incubated for 6 days at 65°C. 30-180 μM SY was used in the study.•SY showed…”
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Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization by Madhav, Hari, Abdel-Rahman, Somaya A., Hashmi, Md Amiruddin, Rahman, Md Ataur, Rehan, Mohammad, Pal, Kavita, Nayeem, Shahid M., Gabr, Moustafa T., Hoda, Nasimul

“…Multi-target directed ligands (MTDLs) have recently attracted significant interest due to their exceptional effectiveness against multi-factorial Alzheimer's…”
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Biophysical characterization of structural and conformational changes in methylmethane sulfonate modified DNA leading to the frizzled backbone structure and strand breaks in DNA by Mustafa, Mohd, Ali, Asif, Siddiqui, Shahid Ali, Mir, Abdul Rouf, Kausar, Tasneem, Nayeem, Shahid M., Abidi, Minhal, Habib, Safia

“…Methyl methanesulfonate (MMS) is a highly toxic DNA-alkylating agent that has a potential to damage the structural integrity of DNA. This work employed…”
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Residues of Alpha Helix H3 Determine Distinctive Features of Transforming Growth Factor β3 by Nayeem, Shahid M, Oteri, Francesco, Baaden, Marc, Deep, Shashank

“…Transforming growth factors (TGF-βs) are proteins that regulate cell growth by binding to their receptors. In contrast to transforming growth factor (TGF) β1,…”
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