Search Results - "Nayar, Shikha"

A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease by Nayar, Shikha, Morrison, Joshua K., Giri, Mamta, Gettler, Kyle, Chuang, Ling-shiang, Walker, Laura A., Ko, Huaibin M., Kenigsberg, Ephraim, Kugathasan, Subra, Merad, Miriam, Chu, Jaime, Cho, Judy H.

“…Crohn’s disease is a chronic inflammatory intestinal disease that is frequently accompanied by aberrant healing and stricturing complications. Crosstalk…”
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From single-target to cellular niche targeting in Crohn's disease: intercepting bad communications by Nayar, Shikha, Cho, Judy H.

“…The mainstay of moderate to severe Crohn's disease (CD), anti-TNF treatment, shows no clinical benefit in ∼40% of patients, likely due to incomplete cellular…”
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MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect by Shtraizent, Nataly, DeRossi, Charles, Nayar, Shikha, Sachidanandam, Ravi, Katz, Liora S, Prince, Adam, Koh, Anna P, Vincek, Adam, Hadas, Yoav, Hoshida, Yujin, Scott, Donald K, Eliyahu, Efrat, Freeze, Hudson H, Sadler, Kirsten C, Chu, Jaime

“…Rapid cellular proliferation in early development and cancer depends on glucose metabolism to fuel macromolecule biosynthesis. Metabolic enzymes are presumed…”
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Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease by Chuang, Ling-Shiang, Morrison, Joshua, Hsu, Nai-Yun, Labrias, Philippe Ronel, Nayar, Shikha, Chen, Ernie, Villaverde, Nicole, Facey, Jody Ann, Boschetti, Gilles, Giri, Mamta, Castillo-Martin, Mireia, Thin, Tin Htwe, Sharma, Yashoda, Chu, Jaime, Cho, Judy H

“…Genome-wide association studies have identified over 200 genomic loci associated with inflammatory bowel disease (IBD). High-effect risk alleles define key…”
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Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver by Morrison, Joshua K., DeRossi, Charles, Alter, Isaac L., Nayar, Shikha, Giri, Mamta, Zhang, Chi, Cho, Judy H., Chu, Jaime

“…The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been…”
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Glycemic index of wheat and rice are similar when consumed as part of a North Indian mixed meal by Nayar, Shikha, Madhu, S

“…Introduction: Wheat is preferable over rice due to its lower glycemic index (GI). It is not known if the same is true when these staples are a part of mixed…”
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Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy by Martin, Jerome C., Chang, Christie, Boschetti, Gilles, Ungaro, Ryan, Giri, Mamta, Grout, John A., Gettler, Kyle, Chuang, Ling-shiang, Nayar, Shikha, Greenstein, Alexander J., Dubinsky, Marla, Walker, Laura, Leader, Andrew, Fine, Jay S., Whitehurst, Charles E., Mbow, M Lamine, Kugathasan, Subra, Denson, Lee A., Hyams, Jeffrey S., Friedman, Joshua R., Desai, Prerak T., Ko, Huaibin M., Laface, Ilaria, Akturk, Guray, Schadt, Eric E., Salmon, Helene, Gnjatic, Sacha, Rahman, Adeeb H., Merad, Miriam, Cho, Judy H., Kenigsberg, Ephraim

“…Clinical benefits of cytokine blockade in ileal Crohn’s disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD…”
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NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell signatures by Hsu, Nai-Yun, Nayar, Shikha, Gettler, Kyle, Talware, Sayali, Giri, Mamta, Alter, Isaac, Argmann, Carmen, Sabic, Ksenija, Thin, Tin Htwe, Ko, Huai-Bin Mabel, Werner, Robert, Tastad, Christopher, Stappenbeck, Thaddeus, Azabdaftari, Aline, Uhlig, Holm H, Chuang, Ling-Shiang, Cho, Judy H

“…Loss-of-function mutations in genes generating reactive oxygen species (ROS), such as , are associated with IBD. Mechanisms whereby loss of ROS drive IBD are…”
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Machine learning identifies novel blood protein predictors of penetrating and stricturing complications in newly diagnosed paediatric Crohn's disease by Ungaro, Ryan C., Hu, Liangyuan, Ji, Jiayi, Nayar, Shikha, Kugathasan, Subra, Denson, Lee A., Hyams, Jeffrey, Dubinsky, Marla C., Sands, Bruce E., Cho, Judy H.

“…Summary Background There is a need for improved risk stratification in Crohn's disease. Aim To identify novel blood protein biomarkers associated with future…”
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Mononuclear Phagocyte Differentiation Highlights the Role of NOD2 in Stricturing Crohn's Disease, Revealing New Therapeutic Targets by Nayar, Shikha

“…Crohn’s disease (CD) is a chronic inflammatory intestinal disease, with frequent aberrant healing and fibrostenotic complications. Increasingly, single-cell…”
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Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target by Chen, Ernie, Chuang, Ling-shiang, Giri, Mamta, Villaverde, Nicole, Hsu, Nai-yun, Sabic, Ksenija, Joshowitz, Sari, Gettler, Kyle, Nayar, Shikha, Chai, Zhi, Alter, Isaac L., Chasteau, Colleen C., Korie, Ujunwa M., Dzedzik, Siarhei, Thin, Tin Htwe, Jain, Aayushee, Moscati, Arden, Bongers, Gerardus, Duerr, Richard H., Silverberg, Mark S., Brant, Steven R., Rioux, John D., Peter, Inga, Schumm, L. Philip, Haritunians, Talin, McGovern, Dermot P., Itan, Yuval, Cho, Judy H.

“…Recent literature has implicated a key role for mast cells in murine models of colonic inflammation, but their role in human ulcerative colitis (UC) is not…”
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102: DISCOVERY AND VALIDATION OF A BLOOD PROTEIN PANEL ASSOCIATED WITH TUMOR NECROSIS FACTOR ANTAGONIST TREATMENT FAILURE IN RECENTLY DIAGNOSED CROHN'S DISEASE (CD) PATIENTS by Ungaro, Ryan C., Hu, Liangyuan, Ji, Jiayi, Nayar, Shikha, Kugathasan, Subra, Denson, Lee A., Hyams, Jeffrey S., Dubinsky, Marla, Leleiko, Neal S., Shapiro, Jason M., Shah, Samir A., Sands, Bruce E., Cho, Judy H.

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A Role for CXCR3 Ligands as Biomarkers of Post-Operative Crohn’s Disease Recurrence by Walshe, Margaret, Nayeri, Shadi, Ji, Jiayi, Hernandez-Rocha, Cristian, Sabic, Ksenija, Hu, Liangyuan, Giri, Mamta, Nayar, Shikha, Brant, Steven, McGovern, Dermot P B, Rioux, John D, Duerr, Richard H, Cho, Judy H, Schumm, Phil L, Lazarev, Mark, Silverberg, Mark S

“…Abstract Background and Aims Crohn’s disease [CD] recurrence following ileocolic resection [ICR] is common. We sought to identify blood-based biomarkers…”
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374 INFLAMED ULCERATIVE COLITIS REGIONS ASSOCIATED TO MRGPRX2-MEDIATED MAST CELL DEGRANULATION AND CELL ACTIVATION MODULES, DEFINING A NEW THERAPEUTIC TARGET by Chuang, Ling-shiang F., Chen, Ernie, Giri, Mamta, Villaverde, Nicole, Hsu, Nai-yun, Sabic, Ksenija, Joshowitz, Sari, Gettler, Kyle, Nayar, Shikha, Chai, Zhi, Alter, Isaac, Chasteau, Colleen, Korie, Ujunwa, Dzedzik, Siarhei, Thin, Tin Htwe, Jain, Aayushee, Moscati, Arden, Bongers, Gerold, Duerr, Richard H., Silverberg, Mark S., Brant, Steven R., Rioux, John D., Peter, Inga, Schumm, L. Philip, Haritunians, Talin, Mcgovern, Dermot P.B., Itan, Yuval, Cho, Judy H.

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trappc11 is required for protein glycosylation in zebrafish and humans by DeRossi, Charles, Vacaru, Ana, Rafiq, Ruhina, Cinaroglu, Ayca, Imrie, Dru, Nayar, Shikha, Baryshnikova, Anastasia, Milev, Miroslav P, Stanga, Daniela, Kadakia, Dhara, Gao, Ningguo, Chu, Jaime, Freeze, Hudson H, Lehrman, Mark A, Sacher, Michael, Sadler, Kirsten C

“…Activation of the unfolded protein response (UPR) can be either adaptive or pathological. We term the pathological UPR that causes fatty liver disease a…”
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Inflamed ulcerative colitis regions associated to MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target by Chen, Ernie, Chuang, Ling-shiang, Giri, Mamta, Villaverde, Nicole, Hsu, Nai-yun, Sabic, Ksenija, Joshowitz, Sari, Gettler, Kyle, Nayar, Shikha, Chai, Zhi, Alter, Isaac L., Chasteau, Colleen C., Korie, Ujunwa M., Dzedzik, Siarhei, Thin, Tin Htwe, Jain, Aayushee, Moscati, Arden, Bongers, Gerardus, Duerr, Richard H., Silverberg, Mark S., Brant, Steven R., Rioux, John D., Peter, Inga, Schumm, L. Philip, Haritunians, Talin, McGovern, Dermot P., Itan, Yuval, Cho, Judy H.

“…Inflamed ulcerative colitis regions demonstrate MRGPRX2-mediated degranulation of activated mast cells, implicating a positive feedback inflammatory loop…”
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