Search Results - "Nayani, Kiranmai"

Total synthesis of antiviral drug, nirmatrelvir (PF-07321332) by Shekhar, Chandra, Nasam, Rajesh, Paipuri, Siva Ramakrishna, Kumar, Prakash, Nayani, Kiranmai, Pabbaraja, Srihari, Mainkar, Prathama S., Chandrasekhar, Srivari

“…The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2…”
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Synthesis of Dalargin, the synthetic Leu-enkephalin analogue in solid phase peptide synthesis by Nomula, Vishnu, Mainkar, Prathama S., Nayani, Kiranmai

“…[Display omitted] An efficient and fast synthesis of dalargin, a potent synthetic opioid peptide was achieved on gram scale within 2 days, with 98% HPLC purity…”
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Rh-Catalyzed Twofold Conjugate Addition of 2‑Arylimidazo[1,2‑a]pyridines to p‑Quinols To Access Bridged Scaffolds with Three Contiguous Stereocenters by Battula, Shravani, Bukya, Hemalatha, Chandra Shekar, Kunta, Nayani, Kiranmai

“…A Rh­(III)-catalyzed annulation of 2-arylimidazo­[1,2-a]­pyridines with p-quinols has been realized, leading to bridged heterocycles with three contiguous…”
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Construction of Octahydro‐4 H ‐cyclopenta[ b ]pyridin‐6‐one Skeletons using Pot, Atom, and Step Economy (PASE) Synthesis by Raju, Silver, Ghosh, Palash, Nayani, Kiranmai, Prashanth, Jupally, Sridhar, Balasubramanian, Mainkar, Prathama S., Chandrasekhar, Srivari

“…Abstract Cascade aza‐Piancatelli reaction and [3+3]/[4+2] cycloaddition reactions are carried out using the ideality principles of pot, atom, and step economy…”
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Construction of Octahydro‐4H‐cyclopentapyridin‐6‐one Skeletons using Pot, Atom, and Step Economy (PASE) Synthesis by Silver, Raju, Ghosh, Palash, Nayani, Kiranmai, Jupally Prashanth, Balasubramanian Sridhar, Mainkar, Prathama S, Chandrasekhar, Srivari

“…Cascade aza‐Piancatelli reaction and [3+3]/[4+2] cycloaddition reactions are carried out using the ideality principles of pot, atom, and step economy (PASE)…”
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Metal-free dearomative 2,3-difunctionalization of indoles via radical cascade by Pal, Pranesh, Goud, Gadela Karteek, Sridhar, Balasubramanian, Mainkar, Prathama S., Nayani, Kiranmai, Chandrasekhar, Srivari

“…[Display omitted] An oxidative dearomatization of protected indoles leading to 2-azido 3-arylselenyl indolines has been developed under metal-free conditions…”
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Functionalization of tyrosine containing short peptides via oxidative dearomatization strategy by Jha, Babli K., Karmakar, Santanu, Dhanaji, Jadhav Rahul, Mainkar, Prathama S., Nayani, Kiranmai, Chandrasekhar, Srivari

“…[Display omitted] An efficient strategy to afford pyrrolidine derivatised peptides through late-stage modification of tyrosine-containing short peptides is…”
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Cation Triggered Domino Aza-Piancatelli Rearrangement/Friedel–Crafts Alkylation of Indole-Tethered Furfuyl Alcohols to Access Cycloocta[b]indole Core of Alkaloids by Vonteddu, Nagarjuna Reddy, Solanke, Pooja R, Nayani, Kiranmai, Chandrasekhar, Srivari

“…A domino approach to bridged cycloocta­[b]­indolone through a cascade of aza-Piancatelli rearrangement/Friedel–Crafts alkylation is developed. This…”
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Construction of Octahydro‐4H‐cyclopenta[b]pyridin‐6‐one Skeletons using Pot, Atom, and Step Economy (PASE) Synthesis by Raju, Silver, Ghosh, Palash, Nayani, Kiranmai, Prashanth, Jupally, Sridhar, Balasubramanian, Mainkar, Prathama S., Chandrasekhar, Srivari

“…Cascade aza‐Piancatelli reaction and [3+3]/[4+2] cycloaddition reactions are carried out using the ideality principles of pot, atom, and step economy (PASE)…”
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Quaternary carbon construction through Piancatelli rearrangement: easy access to spirocyclopentenones by Solanke, Pooja R, Cinsani, Radhika, Nayani, Kiranmai, Mainkar, Prathama S, Chandrasekhar, Srivari

“…A new and efficient approach to a series of novel multifunctionalized spirocyclopentenone scaffolds through Piancatelli rearrangement was developed under…”
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Benzoisothiazolone (BIT): A Fast, Efficient, and Recyclable Redox Reagent for Solid Phase Peptide Synthesis by Bukya, Hemalatha, Nayani, Kiranmai, Gangireddy, Pavankumar, Mainkar, Prathama S.

“…Solid‐phase peptide synthesis (SPPS), a preferred synthetic procedure, generates by‐products and effluents in multiple equivalents for one equivalent of…”
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Metal Free Domino β‑Azidation/[3 + 2] Cycloaddition Reaction for the Synthesis of 1,2,3-Triazole-Fused Dihydrobenzoxazinones by Donikela, Sangeetha, Mainkar, Prathama S, Nayani, Kiranmai, Chandrasekhar, Srivari

“…A metal free DBU catalyzed synthesis of 1,2,3-triazole-fused dihydrobenzoxazinone derivatives by tandem β-azidation/[3 + 2] cycloaddition reaction has been…”
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6‐Strand to Stable 10/12 Helix Conformational Switch by Incorporating Flexible β‐hGly in the Homooligomers of Camphor Derived β‐Amino Acid: NMR and X‐Ray Crystallographic Evidence by Sukumar, Genji, Rahul, Nayani, Kiranmai, Mainkar, Prathama S., Prashanth, Jupally, Sridhar, Balasubramanian, Sarma, Akella V. S., Bharatam, Jagadeesh, Chandrasekhar, Srivari

“…Rational design of unnatural amino acid building blocks capable of stabilizing predictable secondary structures similar to protein fragments is pivotal for…”
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A practical synthesis of C14–C26 fragment of anticancer drug, eribulin mesylate by Lavanya, Nadella, Kiranmai, Nayani, Mainkar, Prathama S., Chandrasekhar, Srivari

“…[Display omitted] High yielding synthesis of C14–C26 fragment of eribulin is achieved from commercially available R-(+)-citronellol and 1,4-butane diol…”
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Design principles and functional basis of enantioselectivity of alanyl-tRNA synthetase and a chiral proofreader during protein biosynthesis by Sivakumar, Koushick, Venkadasamy, Vinitha Lakshmi, Amudhan, Gurumoorthy, Ann, Kezia J, Goud, Gadela Karteek, Nayani, Kiranmai, Gogoi, Jotin, Kuncha, Santosh Kumar, Mainkar, Prathama S, Kruparani, Shobha P, Sankaranarayanan, Rajan

“…Abstract Homochirality of the cellular proteome is attributed to the L-chiral bias of the translation apparatus. The chiral specificity of enzymes was…”
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Brønsted Acid Catalyzed Domino Aza‐Piancatelli Rearrangement/Michael Reaction: Construction of 1,4‐Benzodiazepin‐5‐ones in One Pot by Nayani, Kiranmai, Cinsani, Radhika, Hussaini SD, Anwar, Mainkar, Prathama S., Chandrasekhar, Srivari

“…A para‐toluenesulfonic acid (pTSA) catalyzed domino aza‐Piancatelli rearrangement/Michael reaction was developed for the construction of…”
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Synthesis of cytotoxic cyanobactin, Wewakazole B by Nayani, Kiranmai, Anwar Hussaini, SD

“…[Display omitted] •We have developed a suitable solution phase synthesis of cyclic peptide, Wewakazole B.•The key steps of the synthesis are the macrocyclic…”
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Development of Synthetic Approaches Towards HIV Integrase Strand Transfer Inhibitors (INSTIs) by Sawant, Ashwini Amol, Jadav, Surender Singh, Nayani, Kiranmai, Mainkar, Prathama S.

“…A clear and precise report on synthetic methods for INSTIs and their intermediates are provided in the present work. HIV Integrase strand transfer inhibitors…”
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6‐Strand to Stable 10/12 Helix Conformational Switch by Incorporating Flexible β‐hGly in the Homooligomers of Camphor Derived β‐Amino Acid: NMR and X‐Ray Crystallographic Evidence by Sukumar, Genji, Rahul, Nayani, Kiranmai, Mainkar, Prathama S., Prashanth, Jupally, Sridhar, Balasubramanian, Sarma, Akella V. S., Bharatam, Jagadeesh, Chandrasekhar, Srivari

“…Rational design of unnatural amino acid building blocks capable of stabilizing predictable secondary structures similar to protein fragments is pivotal for…”
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Novel helical foldamers: organized heterogeneous backbone folding in 1 : 1 alpha/nucleoside-derived-beta-amino acid sequences by Chandrasekhar, Srivari, Kiranmai, Nayani, Kiran, Marelli Udaya, Devi, Ambure Sharada, Reddy, Gangireddy Pavan Kumar, Idris, Mohammed, Jagadeesh, Bharatam

“…Secondary structural conformation of hybrid oligo-peptides comprised of 1 : 1 alternating Nucleoside Derived beta-Amino acid (NDA) and l-amino acid residues…”
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