Search Results - "Nayak, V. Lakshma"

Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers by Subba Rao, A.V., Swapna, Konderu, Shaik, Siddiq Pasha, Lakshma Nayak, V., Srinivasa Reddy, T., Sunkari, Satish, Shaik, Thokhir Basha, Bagul, Chandrakant, Kamal, Ahmed

“…[Display omitted] A series of colchicine site binding tubulin inhibitors were synthesized by the modification of the combretastatin pharmacophore. The ring B…”
Get full text

Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors by Ganga Reddy, V., Srinivasa Reddy, T., Lakshma Nayak, V., Prasad, Budaganaboyina, Reddy, Adiyala Praveen, Ravikumar, A., Taj, Shaik, Kamal, Ahmed

“…A series of new (N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives (8–35) were designed, synthesized and evaluated…”
Get full text

Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption by Yugandhar, D., Nayak, V. Lakshma, Archana, Sivakumar, Shekar, Kunta Chandra, Srivastava, Ajay Kumar

“…A series of twenty seven oxa/azaspiro[4,5]trienone derivatives were synthesized and their anticancer properties have been explored. GI50 values of all these…”
Get full text

Comprehensive Analysis of Secondary Metabolites in Usnea longissima (Lichenized Ascomycetes, Parmeliaceae) Using UPLC-ESI-QTOF-MS/MS and Pro-Apoptotic Activity of Barbatic Acid by Reddy, S Divya, Siva, Bandi, Kumar, Katragunta, Babu, V S Phani, Sravanthi, Vemireddy, Boustie, Joel, Nayak, V Lakshma, Tiwari, Ashok K, Rao, C H V, Sridhar, B, Shashikala, P, Babu, K Suresh

“…Considering the importance of ultra-performance liquid chromatography-electrospray ionization-quadrupole time of flight-tandem mass spectrometry…”
Get full text

Design, synthesis and biological evaluation of novel cationic liposomes loaded with melphalan for the treatment of cancer by Sharma, Mani, Sudha Ambadipudi, S.S.S.S., Kumar Chouhan, Neeraj, Lakshma Nayak, V., Pabbaraja, Srihari, Balaji Andugulapati, Sai, Sistla, Ramakrishna

“…[Display omitted] Therapeutically active lipids in drug delivery systems offer customization for enhanced pharmaceutical and biological effects, improving…”
Get full text

Design and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIα inhibition by Sankara Rao, N, Nagesh, Narayana, Lakshma Nayak, V, Sunkari, Satish, Tokala, Ramya, Kiranmai, Gaddam, Regur, Phanindranath, Shankaraiah, Nagula, Kamal, Ahmed

“…A new series of different naphthalimide-benzothiazole/cinnamide derivatives were designed, synthesized and tested for their cytotoxicity on selected human…”
Get full text

Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents by Amujuri, Devi, Siva, Bandi, Poornima, B., Sirisha, Katukuri, Sarma, A.V.S., Lakshma Nayak, V., Tiwari, Ashok K., Purushotham, U., Suresh Babu, K.

“…A new series of Schizandrin (1) derivatives were synthesized utilizing the C-9 position of the Schizandrin core and evaluated for their cytotoxic activities…”
Get full text

Synthesis and biological evaluation of imidazo[2,1-b]thiazole-benzimidazole conjugates as microtubule-targeting agents by Baig, Mirza Feroz, Nayak, V. Lakshma, Budaganaboyina, Prasad, Mullagiri, Kishore, Sunkari, Satish, Gour, Jitendra, Kamal, Ahmed

“…[Display omitted] •Imidazo[2,1-b]thiazole linked benzimidazole conjugates (6a–u) showed cytotoxic activity.•Compound 6d showed significant cytotoxic activity…”
Get full text

Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines by Kamal, Ahmed, Ramakrishna, G., Raju, P., Rao, A.V. Subba, Viswanath, A., Nayak, V. Lakshma, Ramakrishna, Sistla

“…A series of oxindole derivatives of imidazo[1,5-a]pyrazines were prepared and confirmed by 1H NMR, mass and HRMS data. These compounds were evaluated for their…”
Get full text

Design and Synthesis of C3-Pyrazole/Chalcone-Linked Beta-Carboline Hybrids: Antitopoisomerase I, DNA-Interactive, and Apoptosis-Inducing Anticancer Agents by Kamal, Ahmed, Srinivasulu, Vunnam, Nayak, V. Lakshma, Sathish, Manda, Shankaraiah, Nagula, Bagul, Chandrakant, Reddy, N. V. Subba, Rangaraj, Nandini, Nagesh, Narayana

“…A series of β‐carboline hybrids bearing a substituted phenyl and a chalcone/(N‐acetyl)‐pyrazole moiety at the C1 and C3 positions, respectively, was designed,…”
Get full text

Methyl angolensate and mexicanolide-type limonoids from the seeds of Cipadessa baccifera by Siva, Bandi, Poornima, B., Venkanna, A., Prasad, K. Rajendra, Sridhar, B., Lakshma Nayak, V., Ramakrishna, Sistla, Babu, K. Suresh

“…Six new methyl angolensate type (1–6) and three new mexicanolide-type (7–9) limonoids, along with six known limonoids (10–15), were isolated from the seeds of…”
Get full text

Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway by Kamal, Ahmed, Rao, A V Subba, Nayak, V Lakshma, Reddy, N V Subba, Swapna, Konderu, Ramakrishna, G, Alvala, Mallika

“…A series of imidazo[1,5-a]pyridine-benzimidazole hybrids (5a–aa) were prepared and evaluated for their cytotoxic activity against a panel of sixty human tumor…”
Get more information

Synthesis and biological evaluation of bergenin-1,2,3-triazole hybrids as novel class of anti-mitotic agents by Pavan Kumar, P., Siva, Bandi, Venkateswara Rao, Banoth, Dileep Kumar, G., Lakshma Nayak, V., Nishant Jain, S., Tiwari, Ashok K, Purushotham, U., Venkata Rao, C., Suresh Babu, K.

“…A series of bergenin-triazole hybrids were synthesized based on “Click” reaction and tested for cytotoxic activities. Among the congeners, 4j showed potent…”
Get full text

Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents by Prasad, Budaganaboyina, Lakshma Nayak, V., Srikanth, P.S., Baig, Mirza Feroz, Subba Reddy, N.V., Babu, Korrapati Suresh, Kamal, Ahmed

“…[Display omitted] •Conjugates (7a–7al) were design, synthesized and evaluated for their cytotoxic activity.•Conjugates 7a, 7b, 7c, 7f, 7h, 7j, 7m, 7n exhibited…”
Get full text

Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents by Shaik, Thokhir B., Hussaini, S.M. Ali, Nayak, V. Lakshma, Sucharitha, M. Lakshmi, Malik, M. Shaheer, Kamal, Ahmed

“…[Display omitted] Based on our previous results and literature precedence, a series of 2-anilinopyridinyl-benzothiazole Schiff bases were rationally designed…”
Get full text

Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers by Sunkari, Satish, Bonam, Srinivasa Reddy, Rao, A.V. Subba, Riyaz, Sd, Lakshma Nayak, V., Kumar, Halmuthur Mahabalarao Sampath, Kamal, Ahmed, Nagendra Babu, Bathini

“…[Display omitted] •Imidazo[1,5-a]pyridine-bisindole conjugates(5a-t) as apoptis inducedrs.•Conjugate 5k IC50 value 1.6 µM againt Lung cancer cell line.•Arrest…”
Get full text

Design, synthesis and biological evaluation of imidazopyridine-propenone conjugates as potent tubulin inhibitors by Sayeed, Ibrahim Bin, Lakshma Nayak, V, Shareef, Mohd Adil, Chouhan, Neeraj Kumar, Kamal, Ahmed

“…A library of imidazopyridine-propenone conjugates ( ) were synthesized and evaluated for their antitumor activity against four human cancer cell lines, namely,…”
Get full text

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers by Kamal, Ahmed, Tamboli, Jaki R., Nayak, V. Lakshma, Adil, S.F., Vishnuvardhan, M.V.P.S., Ramakrishna, S.

“…A series of terphenyl based 4-aza-2,3-didehydropodophyllotoxin conjugates (8a–r) were synthesized by a straightforward one-step multicomponent synthesis that…”
Get full text

Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/mTOR signaling pathway in human breast cancer cells by Kamal, Ahmed, Lakshma Nayak, V., Nagesh, Narayana, Vishnuvardhan, M.V.P.S., Subba Reddy, N.V.

“…Benzo[b]furan derivatives (26 and 36) showed significant antiproliferative activity against human breast cancer cell line, MCF-7. These benzo[b]furan…”
Get full text

Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents by Kamal, Ahmed, Mallareddy, Adla, Suresh, Paidakula, Shaik, Thokhir B., Lakshma Nayak, V., Kishor, Chandan, Shetti, Rajesh V.C.R.N.C., Sankara Rao, N., Tamboli, Jaki R., Ramakrishna, S., Addlagatta, Anthony

“…A series of chalcone-amidobenzothiazole conjugates (9a–k and 10a,b) have been synthesized and evaluated for their anticancer activity. All these compounds…”
Get full text