Search Results - "Nayak, S.P."
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Gut Enterobacteriaceae and uraemic toxins - Perpetrators for ageing
Published in Experimental gerontology (01-03-2023)“…Ageing is a complex process that is associated with changes in the composition and functions of gut microbiota. Reduction of gut commensals is the hallmarks of…”
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Expanding germ-organ theory: Understanding non-communicable diseases through enterobacterial translocation
Published in Pharmacological research (01-08-2023)“…Diverse microbial communities colonize different habitats of the human body, including gut, oral cavity, nasal cavity and tissues. These microbial communities…”
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Toxic ties: Unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease
Published in Environmental pollution (1987) (01-12-2023)“…Environmental pollution is inherently linked to several metabolic diseases and high mortality. The kidney is more susceptible to environmental pollutants…”
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Prophylactic effects of apigenin against hyperglycemia-associated amnesia via activation of the Nrf2/ARE pathway in zebrafish
Published in European journal of pharmacology (05-08-2024)“…The escalating focus on ageing-associated disease has generated substantial interest in the phenomenon of cognitive impairment linked to diabetes…”
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Indole-3 acetic acid induced cardiac hypertrophy in Wistar albino rats
Published in Toxicology and applied pharmacology (01-05-2024)“…Indole-3-acetic acid (IAA) is the most widely utilized plant growth regulator. Despite its extensive usage, IAA is often overlooked as an environmental…”
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Furan-based chalcone protects β-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetic model via influencing Peroxisome Proliferator-Activated Receptor agonists (PPAR-γ) signaling
Published in Process biochemistry (1991) (01-07-2024)“…Diabetes mellitus, a major global health concern, is emerging as the primary human disease in the twenty-first century, with beta cell damage and dysfunction…”
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Indole-3-acetic acid exposure leads to cardiovascular inflammation and fibrosis in chronic kidney disease rat model
Published in Food and chemical toxicology (01-10-2024)“…Indole-3-acetic acid (IAA), a protein-bound uremic toxin, has been linked to cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients…”
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Furan based synthetic chalcone derivative functions against gut inflammation and oxidative stress demonstrated in in-vivo zebrafish model
Published in European journal of pharmacology (15-10-2023)“…Inflammatory Bowel Disease (IBD) is a group of persistent intestinal illnesses resulting from bowel inflammation unrelated to infection. The prevalence of IBD…”
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Luteolin, a promising quorum quencher mitigates virulence factors production in Pseudomonas aeruginosa - In vitro and In vivoapproach
Published in Microbial pathogenesis (01-07-2023)“…Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes healthcare-associated infection and high mortality in immunocompromised patients. It…”
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Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-01-2024)“…We have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish…”
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Multifaceted evaluation of pyrazole derivative (T4)-chitosan (CS) nanoparticles: Morphology, drug release, and anti-tumor efficacy in a rat model
Published in International journal of biological macromolecules (01-12-2024)“…The development of targeted nanotherapeutics has emerged as a pivotal advancement in cancer treatment, aiming to enhance the efficacy and specificity of drug…”
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Toxicity and therapeutic property of dioxopiperidin derivative SKT40 demonstrated in-vivo zebrafish model due to inflammatory bowel disease
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-10-2024)“…Inflammatory bowel disease (IBD) encompasses chronic disorders that cause severe inflammation in the digestive tract. This study evaluates…”
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Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms
Published in Microbial pathogenesis (01-12-2024)“…Rheumatoid arthritis, a chronic autoimmune disorder characterized by joint inflammation, is thought to be exacerbated by bacterial infections, notably Proteus…”
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Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model
Published in Food and chemical toxicology (01-09-2024)“…The prevalent use of Azorubine (E122) and the unintentional food additive, Bisphenol A (BPA), in ready-to-drink (RTD) beverages raises significant health…”
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Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors
Published in Environmental toxicology and pharmacology (01-08-2024)“…Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential…”
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COX-2 targeted therapy for diabetic foot ulcers using T7-enhanced CS-PVA membranes
Published in International immunopharmacology (25-12-2024)“…•Chitosan-polyvinylalcohol (CS-PVA) membrane inhibits growth of pathogenic bacteria.•T7, a selective COX-2 inhibitor accelerates wound healing potential of…”
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Neuroprotective potential of pyrazole benzenesulfonamide derivative T1 in targeted intervention against PTZ-induced epilepsy-like condition in in vivo zebrafish model
Published in International immunopharmacology (20-04-2024)“…[Display omitted] •Pyrazole benzenesulfonamide derivative T1 inhibits COX-2 targeted intervention.•T1 shields against PTZ-induced cellular damage, affirming…”
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A novel brominated chalcone derivative as a promising multi-target inhibitor against multidrug-resistant Listeria monocytogenes
Published in Microbial pathogenesis (01-11-2024)“…Foodborne pathogens continue to challenge public health due to their ability to cause severe illness and their increasing resistance to current antimicrobial…”
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Bisphenol A-induced ovarian damage countered by luteolin: Experiments in in vitro CHO cells and in vivo PCOS phenotype zebrafish
Published in Tissue & cell (01-12-2024)“…Bisphenol-A (BPA) is a widely used chemical that can harm the human body, including the reproductive system. BPA accumulates in the body and is found in 95 %…”
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