Search Results - "Nayak, Renuka R"

Human gut bacterial metabolism drives Th17 activation and colitis by Alexander, Margaret, Ang, Qi Yan, Nayak, Renuka R., Bustion, Annamarie E., Sandy, Moriah, Zhang, Bing, Upadhyay, Vaibhav, Pollard, Katherine S., Lynch, Susan V., Turnbaugh, Peter J.

“…Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains…”
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Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome by Lam, Kathy N., Spanogiannopoulos, Peter, Soto-Perez, Paola, Alexander, Margaret, Nalley, Matthew J., Bisanz, Jordan E., Nayak, Renuka R., Weakley, Allison M., Yu, Feiqiao B., Turnbaugh, Peter J.

“…Mechanistic insights into the role of the human microbiome in the predisposition to and treatment of disease are limited by the lack of methods to precisely…”
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Polymorphic cis- and trans-regulation of human gene expression by Cheung, Vivian G, Nayak, Renuka R, Wang, Isabel Xiaorong, Elwyn, Susannah, Cousins, Sarah M, Morley, Michael, Spielman, Richard S

“…Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in…”
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SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations by Bustion, Annamarie E, Nayak, Renuka R, Agrawal, Ayushi, Turnbaugh, Peter J, Pollard, Katherine S

“…Bacteria within the gut microbiota possess the ability to metabolize a wide array of human drugs, foods, and toxins, but the responsible enzymes for these…”
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Coexpression network based on natural variation in human gene expression reveals gene interactions and functions by Nayak, Renuka R, Kearns, Michael, Spielman, Richard S, Cheung, Vivian G

“…Genes interact in networks to orchestrate cellular processes. Analysis of these networks provides insights into gene interactions and functions. Here, we took…”
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Gene Expression and Genetic Variation in Response to Endoplasmic Reticulum Stress in Human Cells by Dombroski, Beth A., Nayak, Renuka R., Ewens, Kathryn G., Ankener, Wendy, Cheung, Vivian G., Spielman, Richard S.

“…The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) results in the condition called “ER stress,” which induces the unfolded…”
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Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota by Nayak, Renuka R.

“…Shi et al. (2021) in “Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice”…”
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Fanning the Flames of Autoimmunity: The Microbiome in Rheumatic Disease by Nayak, Renuka R.

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The impact of the human gut microbiome on the treatment of autoimmune disease by Nayak, Renuka R., Orellana, Diego A.

“…Summary Autoimmune (or rheumatic) diseases are increasing in prevalence but selecting the best therapy for each patient proceeds in trial‐and‐error fashion…”
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Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation by Nayak, Renuka R., Alexander, Margaret, Deshpande, Ishani, Stapleton-Gray, Kye, Rimal, Bipin, Patterson, Andrew D., Ubeda, Carles, Scher, Jose U., Turnbaugh, Peter J.

“…Immunomodulatory drugs can inhibit bacterial growth, yet their mechanism of action, spectrum, and clinical relevance remain unknown. Methotrexate (MTX), a…”
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Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response by Scher, Jose U., Nayak, Renuka R., Ubeda, Carles, Turnbaugh, Peter J., Abramson, Steven B.

“…In the past three decades, extraordinary advances have been made in the understanding of the pathogenesis of, and treatment options for, inflammatory…”
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Simvastatin induces human gut bacterial cell surface genes by Escalante, Veronica, Nayak, Renuka R., Noecker, Cecilia, Babdor, Joel, Spitzer, Matthew, Deutschbauer, Adam M., Turnbaugh, Peter J.

“…Drugs intended to target mammalian cells can have broad off‐target effects on the human gut microbiota with potential downstream consequences for drug efficacy…”
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Can we modulate the gut microbiome to enhance DMARD efficacy in rheumatoid arthritis? by Blank, Rebecca B., Nayak, Renuka R., Scher, Jose U.

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Mirror, mirror on the wall: which microbiomes will help heal them all? by Nayak, Renuka R, Turnbaugh, Peter J

“…Clinicians have known for centuries that there is substantial variability between patients in their response to medications-some individuals exhibit a…”
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Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy by Wu, Karin C, McCauley, Kathryn E, Lynch, Susan V, Nayak, Renuka R, King, Nicole J, Patel, Sheena, Kim, Tiffany Y, Condra, Katherine, Fadrosh, Doug, Nguyen, Dat, Lin, Din L, Lynch, Kole, Rogers, Stanley J, Carter, Jonathan T, Posselt, Andrew M, Stewart, Lygia, Schafer, Anne L

“…Laparoscopic sleeve gastrectomy (LSG), the most common bariatric surgical procedure, leads to durable weight loss and improves obesity-related comorbidities…”
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Stress-induced changes in gene interactions in human cells by Nayak, Renuka R, Bernal, William E, Lee, Jessica W, Kearns, Michael J, Cheung, Vivian G

“…Cells respond to variable environments by changing gene expression and gene interactions. To study how human cells response to stress, we analyzed the…”
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Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses by Mok, Amanda, Solomon, Olivia, Nayak, Renuka R, Coit, Patrick, Quach, Hong L, Nititham, Joanne, Sawalha, Amr H, Barcellos, Lisa F, Criswell, Lindsey A, Chung, Sharon A

“…ObjectivePrevious studies have shown that differential DNA methylation is associated with SLE susceptibility. How DNA methylation affects the clinical…”
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Polymorphic Cis- and Trans-Regulation of Human Gene Expression: e1000480 by Cheung, Vivian G, Nayak, Renuka R, Wang, Isabel Xiaorong, Elwyn, Susannah, Cousins, Sarah M, Morley, Michael, Spielman, Richard S

“…Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in…”
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