Search Results - "Nayak, Manasa"

Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm? by Flora, Gagan D, Nayak, Manasa K, Ghatge, Madankumar, Chauhan, Anil K

“…Abstract Current antithrombotic therapies used in clinical settings target either the coagulation pathways or platelet activation receptors (P2Y12 or…”
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Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI-Stimulated Human Platelets-Brief Report by Ghatge, Madankumar, Flora, Gagan D, Nayak, Manasa K, Chauhan, Anil K

“…Evolving evidence suggests that besides signaling pathways, platelet activation involves a complex interplay between metabolic pathways to support thrombus…”
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Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade by Kwiecinski, Jakub M, Crosby, Heidi A, Valotteau, Claire, Hippensteel, Joseph A, Nayak, Manasa K, Chauhan, Anil K, Schmidt, Eric P, Dufrêne, Yves F, Horswill, Alexander R

“…Staphylococcus aureus is a leading cause of endovascular infections. This bacterial pathogen uses a diverse array of surface adhesins to clump in blood and…”
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Smooth muscle cell-specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia by Jain, Manish, Dhanesha, Nirav, Doddapattar, Prakash, Chorawala, Mehul R, Nayak, Manasa K, Cornelissen, Anne, Guo, Liang, Finn, Aloke V, Lentz, Steven R, Chauhan, Anil K

“…Fibronectin-splice variant containing extra domain A (Fn-EDA) is associated with smooth muscle cells (SMCs) following vascular injury. The role of SMC-derived…”
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Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology by Behera, Sudhanshu S, Pramanik, Krishna, Nayak, Manasa K

“…Cardiovascular disease (CVD), accounting around 30% of deaths worldwide, collectively comprised of disorders affecting the heart and blood vessels as well as…”
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Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation by Dhanesha, Nirav, Jain, Manish, Tripathi, Amit K., Doddapattar, Prakash, Chorawala, Mehul, Bathla, Girish, Nayak, Manasa K., Ghatge, Madankumar, Lentz, Steven R., Kon, Shigeyuki, Chauhan, Anil K.

“…Currently, there is no effective intervention available that can reduce brain damage following reperfusion. Clinical studies suggest a positive correlation…”
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Smooth Muscle Cell–Specific PKM2 (Pyruvate Kinase Muscle 2) Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia by Jain, Manish, Dhanesha, Nirav, Doddapattar, Prakash, Nayak, Manasa K., Guo, Liang, Cornelissen, Anne, Lentz, Steven R., Finn, Aloke V., Chauhan, Anil K.

“…[Figure: see text]…”
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Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice by Dhanesha, Nirav, Nayak, Manasa K., Doddapattar, Prakash, Jain, Manish, Flora, Gagan D., Kon, Shigeyuki, Chauhan, Anil K.

“…Evidence suggests that neutrophils contribute to thrombosis via several mechanisms, including neutrophil extracellular traps (NETs) formation. Integrin α9β1 is…”
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Constitutively active ADAMTS13: An emerging thrombolytic agent for acute ischemic stroke by Nayak, Manasa K., Flora, Gagan D., Chauhan, Anil K.

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The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis by Nayak, Manasa K., Ghatge, Madankumar, Flora, Gagan D., Dhanesha, Nirav, Jain, Manish, Markan, Kathleen R., Potthoff, Matthew J., Lentz, Steven R., Chauhan, Anil K.

“…Very little is known about the role of metabolic regulatory mechanisms in platelet activation and thrombosis. Dimeric pyruvate kinase M2 (PKM2) is a crucial…”
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Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis by Ghatge, Madankumar, Nayak, Manasa K., Flora, Gagan D., Kumskova, Mariia, Jain, Aditi, Patel, Rakesh B., Lin, Zhihong, Usachev, Yuriy M., Chauhan, Anil K.

“…Mitochondrial calcium uniporter b (MCUb) is a negative regulator of the mitochondrial calcium uniporter (MCU) and is known to limit mitochondrial calcium ion…”
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Aspirin delimits platelet life span by proteasomal inhibition by Nayak, Manasa K, Dash, Ayusman, Singh, Nitesh, Dash, Debabrata

“…Aspirin is widely used in clinical settings as an anti-inflammatory and anti-platelet drug due its inhibitory effect on cyclooxygenase activity. Although the…”
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Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets by Singh, Sunil K, Singh, Manoj K, Nayak, Manasa K, Kumari, Sharda, Shrivastava, Siddhartha, Grácio, José J. A, Dash, Debabrata

“…Graphene oxide (GO), the new two-dimensional carbon nanomaterial, is extensively investigated for potential biomedical applications. Thus, it is pertinent to…”
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Endothelial Cell–Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor–Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation by Dhanesha, Nirav, Prakash, Prem, Doddapattar, Prakash, Khanna, Ira, Pollpeter, Molly J, Nayak, Manasa K, Staber, Janice M, Chauhan, Anil K

“…OBJECTIVE—von Willebrand factor (VWF), which is synthesized in endothelial cells and megakaryocytes, is known to worsen stroke outcome. In vitro studies…”
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Regulatory Role of Proteasome in Determination of Platelet Life Span by Nayak, Manasa K., Kulkarni, Paresh P., Dash, Debabrata

“…Limit of platelet life span (8–10 days) is determined by the activity of a putative “internal clock” composed of Bcl-2 family proteins, whereas the role of…”
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Endothelial Cell–Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E–Deficient Mice by Doddapattar, Prakash, Dhanesha, Nirav, Chorawala, Mehul R, Tinsman, Chandler, Jain, Manish, Nayak, Manasa K, Staber, Janice M, Chauhan, Anil K

“…OBJECTIVE—VWF (von Willebrand factor) is synthesized by endothelial cells and megakaryocytes and is known to contribute to atherosclerosis. In vitro studies…”
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Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia by Kumari, Sharda, Chaurasia, Susheel N., Nayak, Manasa K., Mallick, Ram L., Dash, Debabrata

“…Sirtuins are evolutionarily conserved NAD+-dependent acetyl-lysine deacetylases that belong to class III type histone deacetylases. In humans, seven sirtuin…”
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Improvement of oxidative stress and immunity by melatonin: An age dependent study in golden hamster by Vishwas, Dipanshu Kumar, Mukherjee, Arun, Haldar, Chandana, Dash, Debabrata, Nayak, Manasa K.

“…Reactive oxygen species (ROS) have been proposed to play an important role in balancing the pro- and antioxidant homeostasis during aging. Melatonin has been…”
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ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice by Dhanesha, Nirav, Doddapattar, Prakash, Chorawala, Mehul R, Nayak, Manasa K, Kokame, Koichi, Staber, Janice M, Lentz, Steven R, Chauhan, Anil K

“…OBJECTIVE—ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic…”
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Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis by Flora, Gagan D., Nayak, Manasa K., Ghatge, Madankumar, Kumskova, Mariia, Patel, Rakesh B., Chauhan, Anil K.

“…•Combined deletion of pyruvate dehydrogenase kinase (PDK) 2 and 4 inhibits platelet function and arterial thrombosis.•PDK2/4 contributes to platelet biology by…”
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