Search Results - "Nayak, Deepika"

Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A by Nayak, Deepika, Paul, Subarno, Das, Chinmay, Bhal, Subhasmita, Kundu, Chanakya Nath

“…Cancer stem cells (CSCs) cause drug resistance in cancer due to its extensive drug efflux, DNA repair and self-renewal capability. ATP binding cassette…”
Get full text

The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4 by Siddharth, Sumit, Nayak, Anmada, Das, Sarita, Nayak, Deepika, Panda, Jyochanamayi, Wyatt, Michael D., Kundu, Chanakya Nath

“…•Using in vitro, in vivo, In Ovo and Ex vivo model system we have proved that a pvrl-4 encoded gene Nectin-4 has angiogenesis potentiality.•Nectin-4 is a…”
Get full text

Chitosan-Dextran sulfate coated doxorubicin loaded PLGA-PVA-nanoparticles caused apoptosis in doxorubicin resistance breast cancer cells through induction of DNA damage by Siddharth, Sumit, Nayak, Anmada, Nayak, Deepika, Bindhani, Birendra Kumar, Kundu, Chanakya Nath

“…To overcome the toxicity, pharmacokinetics and drug resistance associated with doxorubicin (DOX), a strategy was developed by encapsulating DOX-…”
Get full text

Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse by Sethy, Chinmayee, Goutam, Kunal, Nayak, Deepika, Pradhan, Rajalaxmi, Molla, Sefinew, Chatterjee, Subhajit, Rout, Niranjan, Wyatt, Michael D., Narayan, Satya, Kundu, Chanakya Nath

“…Purpose In the present study, we have systematically examined the clinical significance of Nectin-4 (encoded by the PVRL - 4 gene), a marker for breast cancer…”
Get full text

PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade by Molla, Sefinew, Hembram, Krushna Chandra, Chatterjee, Subhajit, Nayak, Deepika, Sethy, Chinmayee, Pradhan, Rajalaxmi, Kundu, Chanakya Nath

“…Although Olaparib (Ola, a PARP-inhibitor), in combination with other chemotherapeutic agents, was clinically approved to treat prostate cancer, but…”
Get full text

Retraction Note: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats by Magar, Shital, Nayak, Deepika, Mahajan, Umesh B., Patil, Kalpesh R., Shinde, Sachin D., Goyal, Sameer N., Swaminarayan, Shivang, Patil, Chandragouda R., Ojha, Shreesh, Kundu, Chanakya Nath

“…This paper has been retracted…”
Get full text

RETRACTED ARTICLE: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats by Magar, Shital, Nayak, Deepika, Mahajan, Umesh B., Patil, Kalpesh R., Shinde, Sachin D., Goyal, Sameer N., Swaminarayan, Shivang, Patil, Chandragouda R., Ojha, Shreesh, Kundu, Chanakya Nath

“…Despite the availability of multiple therapeutic agents, the search for novel pain management of neuropathic pain is still a challenge. Oxidative stress and…”
Get full text

Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner by Satapathy, Shakti Ranjan, Nayak, Anmada, Siddharth, Sumit, Das, Sarita, Nayak, Deepika, Kundu, Chanakya Nath

“…Complete eradication of aggressive oral cancer remains a challenge due to the presence of CSCs. They resist conventional chemotherapeutic agents due to their…”
Get full text

Nectin-4 is a breast cancer stem cell marker that induces WNT/β-catenin signaling via Pi3k/Akt axis by Siddharth, Sumit, Goutam, Kunal, Das, Sarita, Nayak, Anmada, Nayak, Deepika, Sethy, Chinmayee, Wyatt, Michael D., Kundu, Chanakya Nath

“…•Nectin-4 is a marker for breast cancer stem cells.•Nectin-4 − upregulates, EMT, metastasis and WNT/β-Catenin pathway via Pi3k/Akt axis.•Nectin-4 depletion…”
Get full text

Design and synthesis of the novel, selective WZ4002 analogue as EGFR-L858R/T790M tyrosine kinase inhibitors for targeted drug therapy in non-small-cell lung cancer (NSCLC) by Pawara, Rahul, Ahmad, Iqrar, Nayak, Deepika, Belamkar, Sateesh, Surana, Sanjay, Kundu, Chanakya Nath, Patil, Chandragauda, Patel, Harun

“…•“U” shape strategy implemented for the designing of the compounds.•L858R/T790M mutation is the most common mechanism of acquired resistance.•Compounds 08 and…”
Get full text

Quinacrine and curcumin synergistically increased the breast cancer stem cells death by inhibiting ABCG2 and modulating DNA damage repair pathway by Nayak, Deepika, Tripathi, Neha, Kathuria, Deepika, Siddharth, Sumit, Nayak, Anmada, Bharatam, Prasad V., Kundu, Chanakya

“…[Display omitted] •Quinacrine and Curcumin synergistically caused apoptosis in breast cancer stem cell like cells (CSCs).•Quinacrine and Curcumin inhibit the…”
Get full text

Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC) by Pawara, Rahul, Ahmad, Iqrar, Nayak, Deepika, Wagh, Shivani, Wadkar, Avinash, Ansari, Azim, Belamkar, Sateesh, Surana, Sanjay, Nath Kundu, Chanakya, Patil, Chandragauda, Patel, Harun

“…[Display omitted] •L858R/T790M mutation is the most common mechanism of acquired resistance.•Compounds 2i and 11h identified as lead compounds.•Compounds were…”
Get full text

Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation by Nayak, Anmada, Das, Sarita, Nayak, Deepika, Sethy, Chinmayee, Narayan, Satya, Kundu, Chanakya Nath

“…Purpose Cervical cancer is a major cause of cancer-related death in women world-wide. Although the anti-metabolite 5-FU is widely used for its treatment, its…”
Get full text

Comparative and Mechanistic Study on the Anticancer Activity of Quinacrine-Based Silver and Gold Hybrid Nanoparticles in Head and Neck Cancer by Hembram, Krushna Chandra, Chatterjee, Subhajit, Sethy, Chinmayee, Nayak, Deepika, Pradhan, Rajalaxmi, Molla, Sefinew, Bindhani, Birendra Kumar, Kundu, Chanakya Nath

“…Using oral cancer cells (in vitro) and in vivo xenograft mice model, we have systematically studied the detailed mechanism of anticancer activity of…”
Get full text

ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli by Siddharth, Sumit, Nayak, Deepika, Nayak, Anmada, Das, Sarita, Kundu, Chanakya Nath

“…[Display omitted] •ABT-888 increased QC mediated DNA damage-induced APC.•Induced APC inhibits PARP1(PAR)ylation and disassemble BER complex.•QC+ABT-888 caused…”
Get full text

Corrigendum to “The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4” [Int J Biochem Cell Biol, 2018, Sep, 102, 151–160] by Siddharth, Sumit, Nayak, Anmada, Das, Sarita, Nayak, Deepika, Panda, Jyochanamayi, Wyatt, Michael D., Kundu, Chanakya Nath

Get full text

Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights by Priyadarsini Mishra, Nilima, Kumar Sahoo, Dipak, Mohapatra, Seetaram, Nayak, Sabita, Nayak, Deepika, Nath Kundu, Chanakya

“…[Display omitted] •Prepared stable 1:1 inclusion complexes of hydrophobic anticancer drug MNC with β-cyclodextrin.•Comprehensive characterization confirmed…”
Get full text

Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and β catenin through activation of GSK3β by Nayak, Anmada, Siddharth, Sumit, Das, Sarita, Nayak, Deepika, Sethy, Chinmayee, Kundu, Chanakya Nath

“…Presences of cancer stem cells (CSCs) in a bulk of cancer cells are responsible for tumor relapse, metastasis and drug resistance in oral cancer. Due to high…”
Get full text

Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2- c ]chromene derivatives following hetero-Diels-Alder reaction and in vitro anticancer studies by Panda, Pravati, Nayak, Sabita, Sahoo, Susanta Ku, Mohapatra, Seetaram, Nayak, Deepika, Pradhan, Rajalaxmi, Kundu, Chanakya Nath

“…The development of concise methods for the synthesis of small functionalised spirocyclic molecules is important in the search of new bioactive molecules. To…”
Get full text

Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects by Sisodiya, Shailendra, Paul, Subarno, Chaudhary, Hiteshkumar, Grewal, Preeti, Kumar, Gulshan, Daniel, Divine P, Das, Biswajit, Nayak, Deepika, Guchhait, Sankar K., Kundu, Chanakya N., Banerjee, Uttam C.

“…[Display omitted] Two series of (hetero)arylamino-naphthoquinones and benzo-fused carbazolequinones were considered for study with the rationale that related…”
Get full text