Search Results - "Nayak, Anindita"

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL by Nayak, Digant, Lv, Dongwen, Yuan, Yaxia, Zhang, Peiyi, Hu, Wanyi, Nayak, Anindita, Ruben, Eliza A., Lv, Zongyang, Sung, Patrick, Hromas, Robert, Zheng, Guangrong, Zhou, Daohong, Olsen, Shaun K.

“…Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of…”
Get full text

Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer by Afsar, Mohammad, Liu, GuanQun, Jia, Lijia, Ruben, Eliza A., Nayak, Digant, Sayyad, Zuberwasim, Bury, Priscila dos Santos, Cano, Kristin E., Nayak, Anindita, Zhao, Xiang Ru, Shukla, Ankita, Sung, Patrick, Wasmuth, Elizabeth V., Gack, Michaela U., Olsen, Shaun K.

“…ISG15 plays a crucial role in the innate immune response and has been well-studied due to its antiviral activity and regulation of signal transduction,…”
Get full text

Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 by Yuan, Lingmin, Gao, Fei, Lv, Zongyang, Nayak, Digant, Nayak, Anindita, Santos Bury, Priscila dos, Cano, Kristin E., Jia, Lijia, Oleinik, Natalia, Atilgan, Firdevs Cansu, Ogretmen, Besim, Williams, Katelyn M., Davies, Christopher, El Oualid, Farid, Wasmuth, Elizabeth V., Olsen, Shaun K.

“…The E1 enzyme Uba6 initiates signal transduction by activating ubiquitin and the ubiquitin-like protein FAT10 in a two-step process involving sequential…”
Get full text

Induction of Transcriptional Inhibitor HES1 and the Related Repression of Tumor-Suppressor TXNIP Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase NPM-ALK by Zhang, Qian, Wang, Hong Y., Nayak, Anindita, Nunez-Cruz, Selene, Slupianek, Artur, Liu, Xiaobin, Basappa, Johnvesly, Fan, Jing-Song, Chekol, Seble, Nejati, Reza, Bogusz, Agata M., Turner, Suzanne D., Swaminathan, Kunchithapadam, Wasik, Mariusz A.

“…This study reports that hairy and enhancer of split homolog-1 (HES1), known to repress gene transcription in progenitor cells of several cell lineages, was…”
Get full text

Optimization of some physical and nutritional parameters for the production of hyaluronidase by Streptococcus equi SED 9 by Sahoo, Sabuj, Panda, Prasana K, Mishra, Satya R, Nayak, Anindita, Ellaiah, Poluri, Dash, Sashi K

“…The effects of some physical and nutritional parameters were studied for the optimum production of an extracellular enzyme hyaluronidase employing…”
Get full text