Particles internalization, oxidative stress, apoptosis and pro-inflammatory cytokines in alveolar macrophages exposed to cement dust

Highlights • We exposed alveolar macrophages to cement dust samples from Nigeria and USA. • Increased membrane blebbing were observed in cells exposed to cement sample from USA. • Cement dust sample from USA induced increased oxidative stress and apoptosis. • Both cement samples induced increased IL...

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Bibliographic Details
Published in:	Environmental toxicology and pharmacology Vol. 37; no. 3; pp. 1060 - 1070
Main Authors:	Ogunbileje, J.O, Nawgiri, R.S, Anetor, J.I, Akinosun, O.M, Farombi, E.O, Okorodudu, A.O
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-05-2014
Subjects:	Air Pollutants, Occupational - toxicity Animals Apoptosis - drug effects Cell Line Cement dust Construction Materials Cytokines - metabolism DNA Fragmentation Dust Emergency Endocytosis Glutathione - metabolism Lung Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Macrophages, Alveolar - ultrastructure Microscopy, Electron, Transmission Oxidative stress induced-apoptosis Pro-inflammatory cytokines Rats Reactive Oxygen Species - metabolism hypobromous acid macrophage inflammatory protein 2 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide glutathione MIP-2 Lung MTT NLRP-3 NR8383 nod-like receptor protein-3 transforming growth factor-beta tumor necrosis factor-alpha Cement dust Endocytosis HOBr matrix metallopeptidase 2 reactive oxygen species TGF-β transmission electron microscopy GSH matrix metallopeptidase 9 alveolar macrophage hypochlorous acid cytokine induced neutrophil chemoattractant-3 MMP2 AM IL-1β MMP9 HOCl interleukin-1 beta alveolar macrophage cell line TNF-α ROS Pro-inflammatory cytokines CINC-3 TEM Oxidative stress induced-apoptosis
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Summary:	Highlights • We exposed alveolar macrophages to cement dust samples from Nigeria and USA. • Increased membrane blebbing were observed in cells exposed to cement sample from USA. • Cement dust sample from USA induced increased oxidative stress and apoptosis. • Both cement samples induced increased IL-1β and TNF-α but decreased CINC-3 secretion. • The severity of cement dust toxicity may be factory dependent.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.03.021