Search Results - "Nawas, Afshan F."

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence by Dahl, Haley C, Kanchwala, Mohammed, Thomas-Jardin, Shayna E, Sandhu, Amrit, Kanumuri, Preethi, Nawas, Afshan F, Xing, Chao, Lin, Chenchu, Frigo, Daniel E, Delk, Nikki A

“…Chronic inflammation promotes prostate cancer (PCa) initiation and progression. We previously reported that acute intereluekin-1 (IL-1) exposure represses…”
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IL-1-conferred gene expression pattern in ERα + BCa and AR + PCa cells is intrinsic to ERα - BCa and AR - PCa cells and promotes cell survival by Nawas, Afshan F, Kanchwala, Mohammed, Thomas-Jardin, Shayna E, Dahl, Haley, Daescu, Kelly, Bautista, Monica, Anunobi, Vanessa, Wong, Ally, Meade, Rachel, Mistry, Ragini, Ghatwai, Nisha, Bayerl, Felix, Xing, Chao, Delk, Nikki A

“…Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or…”
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NF-κB signaling promotes castration-resistant prostate cancer initiation and progression by Thomas-Jardin, Shayna E., Dahl, Haley, Nawas, Afshan F., Bautista, Monica, Delk, Nikki A.

“…Prostate Cancer (PCa) is the second leading cause of cancer-related death in men. Adenocarcinoma of the prostate is primarily composed of Androgen…”
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RELA is sufficient to mediate interleukin‐1 repression of androgen receptor expression and activity in an LNCaP disease progression model by Thomas‐Jardin, Shayna E., Dahl, Haley, Kanchwala, Mohammed S., Ha, Freedom, Jacob, Joan, Soundharrajan, Reshma, Bautista, Monica, Nawas, Afshan F., Robichaux, Dexter, Mistry, Ragini, Anunobi, Vanessa, Xing, Chao, Delk, Nikki A.

“…Background The androgen receptor (AR) nuclear transcription factor is a therapeutic target for prostate cancer (PCa). Unfortunately, patients can develop…”
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Identification of an IL‐1‐induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR− PCa cells by Thomas‐Jardin, Shayna E., Kanchwala, Mohammed S., Jacob, Joan, Merchant, Sana, Meade, Rachel K., Gahnim, Nagham M., Nawas, Afshan F., Xing, Chao, Delk, Nikki A.

“…Background In immunosurveillance, bone‐derived immune cells infiltrate the tumor and secrete inflammatory cytokines to destroy cancer cells. However, cancer…”
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