Search Results - "Navratilova, Marie"
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Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Published in Clinical cancer research (01-08-2008)“…Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau ( VHL ) gene in the cancer…”
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2
Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors
Published in PLoS genetics (01-10-2011)“…Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify disease into molecularly defined subtypes to examine associations…”
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3
Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma
Published in Scientific reports (23-03-2017)“…Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates…”
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Survival and prognostic factors of early‐stage non‐small cell lung cancer in Central and Eastern Europe: A prospective cohort study
Published in Cancer medicine (Malden, MA) (01-05-2023)“…Background Although early diagnosis and surgical resection of the tumor have been shown to be the most important predictors of lung cancer survival, long‐term…”
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Occupational Trichloroethylene Exposure and Renal Carcinoma Risk: Evidence of Genetic Susceptibility by Reductive Metabolism Gene Variants
Published in Cancer research (Chicago, Ill.) (15-08-2010)“…Trichloroethylene (TCE) is a suspected renal carcinogen. TCE-associated renal genotoxicity occurs predominantly through glutathione S-transferase (GST)…”
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Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study
Published in PloS one (27-10-2015)“…Prospective cohort studies have found that prediagnostic circulating vitamin B6 is inversely associated with both risk of kidney cancer and kidney cancer…”
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LINE-1 methylation levels in leukocyte DNA and risk of renal cell cancer
Published in PloS one (04-11-2011)“…Leukocyte global DNA methylation levels are currently being considered as biomarkers of cancer susceptibility and have been associated with risk of several…”
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Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer
Published in BMC cancer (20-05-2008)“…The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or…”
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Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead
Published in PloS one (20-07-2011)“…Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene…”
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10
Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk
Published in PloS one (15-09-2009)“…In the kidney vitamin D is converted to its active form. Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most…”
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Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk
Published in PloS one (19-10-2011)“…Folate and one-carbon metabolism are linked to cancer risk through their integral role in DNA synthesis and methylation. Variation in one-carbon metabolism…”
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An analysis of growth, differentiation and apoptosis genes with risk of renal cancer
Published in PloS one (24-03-2009)“…We conducted a case-control study of renal cancer (987 cases and 1298 controls) in Central and Eastern Europe and analyzed genomic DNA for 319 tagging…”
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13
High occurrence of BRCA1 intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech Republic
Published in BMC medical genetics (11-06-2007)“…Alterations in the highly penetrant cancer susceptibility gene BRCA1 are responsible for the majority of hereditary breast and/or ovarian cancers. However, the…”
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14
Family History and the Risk of Kidney Cancer: a Multicenter Case-control Study in Central Europe
Published in Cancer epidemiology, biomarkers & prevention (01-06-2007)“…An elevated familial relative risk may indicate either an important genetic component in etiology or shared environmental exposures within the family…”
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Occupation and risk of lung cancer in Central and Eastern Europe: the IARC multi-center case-control study
Published in Cancer causes & control (01-08-2007)“…Objective We sought to evaluate the role of occupation and industry in lung carcinogenesis in six countries in Central and Eastern Europe. Methods This…”
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GAPPS - Gastric Adenocarcinoma and Proximal Polyposis of the Stomach Syndrome in 8 Families Tested at Masaryk Memorial Cancer Institute - Prevention and Prophylactic Gastrectomies
Published in Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti (2019)“…Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare variant of familial adenomatous polyposis. It is an autosomal-dominant…”
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Geographic variation of mutagenic exposures in kidney cancer genomes
Published in Nature (London) (23-05-2024)“…International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by…”
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Genetic and preventive services for hereditary breast and ovarian cancer in the czech republic
Published in Hereditary cancer in clinical practice (15-11-2006)“…The majority of hereditary breast and ovarian cancers can be accounted for by germline mutations in the BRCA1 and BRCA2 genes. Genetic counselling and testing…”
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Application of Genomic Sequencing to Refine Patient Stratification for Adjuvant Therapy in Renal Cell Carcinoma
Published in Clinical cancer research (03-04-2023)“…Patients with resected localized clear-cell renal cell carcinoma (ccRCC) remain at variable risk of recurrence. Incorporation of biomarkers may refine risk…”
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Intravesical instillation of onabotulinum toxin A embedded in inert hydrogel in the treatment of idiopathic overactive bladder: A double-blind randomized pilot study
Published in Scandinavian journal of urology (01-06-2016)“…It was hypothesized that increasing the time for which onabotulinum toxin A (OnabotA) is exposed to the urothelium following intravesical instillation will…”
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