Search Results - "Navia, manuel A."

Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1 by Napper, Andrew D, Hixon, Jeffrey, McDonagh, Thomas, Keavey, Kenneth, Pons, Jean-Francois, Barker, Jonathan, Yau, Wei Tsung, Amouzegh, Patricia, Flegg, Adam, Hamelin, Estelle, Thomas, Russell J, Kates, Michael, Jones, Stephen, Navia, Manuel A, Saunders, Jeffrey O, DiStefano, Peter S, Curtis, Rory

“…High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over…”
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A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases by Docherty, Callum Ah, Fernando, Anuruddika J, Rosli, Sarah, Lam, Maggie, Dolle, Roland E, Navia, Manuel A, Farquhar, Ronald, La France, Danny, Tate, Michelle D, Murphy, Christopher K, Rossi, Adriano G, Mansell, Ashley

“…Inflammasomes induce maturation of the inflammatory cytokines IL-1β and IL-18, whose activity is associated with the pathophysiology of a wide range of…”
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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex by Griffith, James P, Kim, Joseph L, Kim, Eunice E, Sintchak, Michael D, Thomson, John A, Fitzgibbon, Matthew J, Fleming, Mark A, Caron, Paul R, Hsiao, Kathy, Navia, Manuel A

“…The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus)…”
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A Chicken in Every Pot, Thanks to Sulfonamide Drugs by Navia, Manuel A., Drews, Jürgen

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Protein Crystals as Novel Microporous Materials by Vilenchik, Lev Z, Griffith, James P, St. Clair, Nancy, Navia, Manuel A, Margolin, Alexey L

“…Cross-linked protein crystals (CLPCs) constitute a novel type of molecular sieves with high porosity. In order to characterize the fully hydrated CLPC, the…”
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Protein Crystals as Novel Catalytic Materials by Margolin, Alexey L., Navia, Manuel A.

“…In this era of molecular biology, protein crystallization is often considered to be a necessary first step in obtaining structural information through X‐ray…”
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Synthesis of Aspartame by Thermolysin: An X‑ray Structural Study by Birrane, Gabriel, Bhyravbhatla, Balaji, Navia, Manuel A

“…Protease mediated peptide synthesis (PMPS) was first described in the 1930s but remains underexploited today. In most PMPS, the reaction equilibrium is shifted…”
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A call to arms: Unifying the fight against resistance by Kaushansky, Alexis, Hedstrom, Lizbeth, Goldman, Aaron, Singh, Juswinder, Yang, Priscilla L, Rathod, Pradipsinh K, Cynamon, Michael, Wodarz, Dominik, Mahadevan, Daruka, Tomaras, Andrew, Navia, Manuel A, Schiffer, Celia A

“…This Editorial discusses the state of research on drug resistance in the fields of cancer, infectious disease, and agriculture. Reaching across the aisle for a…”
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Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1 by Napper, Andrew D, Hixon, Jeffrey, McDonagh, Thomas, Keavey, Kenneth, Pons, Jean-Francois, Barker, Jonathan, Yau, Wei Tsung, Amouzegh, Patricia, Flegg, Adam, Hamelin, Estelle, Thomas, Russell J, Kates, Michael, Jones, Stephen, Navia, Manuel A, Saunders, Jeffrey O, DiStefano, Peter S, Curtis, Rory

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Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1 by Navia, Manuel A, Fitzgerald, Paula M. D, McKeever, Brian M, Leu, Chih-Tai, Heimbach, Jill C, Herber, Wayne K, Sigal, Irving S, Darke, Paul L, Springer, James P

“…The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein…”
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Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity by Longo, Kenneth A, Govek, Elizabeth K, Nolan, Anna, McDonagh, Thomas, Charoenthongtrakul, Soratree, Giuliana, Derek J, Morgan, Kristen, Hixon, Jeffrey, Zhou, Chaoseng, Kelder, Bruce, Kopchick, John J, Saunders, Jeffrey O, Navia, Manuel A, Curtis, Rory, DiStefano, Peter S, Geddes, Brad J

“…Ghrelin influences a variety of metabolic functions through a direct action at its receptor, the GhrR (GhrR-1a). Ghrelin knockout (KO) and GhrR KO mice are…”
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Cross-linked enzyme crystals as robust biocatalysts by St. Clair, Nancy L, Navia, Manuel A

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Structure and mechanism of interleukin-lβ converting enzyme by Wilson, Keith P, Black, Jo-Anne F, Thomson, John A, Kim, Eunice E, Griffith, James P, Navia, Manuel A, Murcko, Mark A, Chambers, Stephen P, Aldape, Robert A, Raybuck, Scott A, Livingston, David J

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Cross-Linked Enzyme Crystals (CLECs) of Thermolysin in the Synthesis of Peptides by Persichetti, Rose A, Clair, Nancy L. S, Griffith, James P, Navia, Manuel A, Margolin, Alexey L

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Protein—drug complexes important for immunoregulation and organ transplantation by Navia, Manuel A

“…Recently, two structures of the Ser/Thr phosphorylase calcineurin in complex with FK506 and its cognate immunophilin, FKBP12, have been reported, both solved…”
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Protein Crystal Growth in Microgravity by DeLucas, Lawrence J., Smith, Craig D., Smith, H. Wilson, Vijay-Kumar, Senadhi, Senadhi, Shobha E., Ealick, Steven E., Carter, Daniel C., Snyder, Robert S., Weber, Patricia C., Salemme, F. Raymond, Ohlendorf, D. H., Einspahr, H. M., Clancy, L. L., Navia, Manuel A., McKeever, Brian M., Nagabhushan, T. L., Nelson, George, McPherson, A., Koszelak, S., Taylor, G., Stammers, D., Powell, K., Darby, G., Bugg, Charles E.

“…The crystals of most proteins or other biological macromolecules are poorly ordered and diffract to lower resolutions than those observed for most crystals of…”
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Career Options in Industry: Consulting /Venture Capital by Navia, Manuel A.

“…Consulting can be an exhilarating and mind‐expanding experience. On the positive side, it has allowed me to share the dreams and adventures of a wide…”
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Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides by Finke, Paul E, Ashe, Bonnie M, Knight, Wilson B, Maycock, Alan L, Navia, Manuel A, Shah, Shrenik K, Thompson, Kevan R, Underwood, Dennis J, Weston, Hazel

“…A variety of 7 alpha-methoxycephalosporin ester and amide sulfones were prepared and tested to determine the structure-activity relations for inhibition of…”
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Crystallographie study of a β -lactam inhibitor complex with elastase at 1.84 Å resolution by Navia, Manuel A, Springer, James P, Lin, Tsau-Yen, Williams, Hollis R, Firestone, Raymond A, Pisano, Judith M, Doherty, James B, Finke, Paul E, Hoogsteen, Karst

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A role for the aspartyl protease from the human immunodeficiency virus type 1 (HIV-1) in the orchestration of virus assembly by Navia, M A, McKeever, B M

“…Functional HIV-1 protease (PR) is required for the maturation of viral proteins, for the appearance of characteristic structural features in the virion (as…”
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