Search Results - "Navegantes, Luiz C. C."

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease by Khan, Muzamil Majid, Lustrino, Danilo, Silveira, Willian A., Wild, Franziska, Straka, Tatjana, Issop, Yasmin, O’Connor, Emily, Cox, Dan, Reischl, Markus, Marquardt, Till, Labeit, Dittmar, Labeit, Siegfried, Benoit, Evelyne, Molgó, Jordi, Lochmüller, Hanns, Witzemann, Veit, Kettelhut, Isis C., Navegantes, Luiz C. C., Pozzan, Tullio, Rudolf, Rüdiger

“…The distribution and function of sympathetic innervation in skeletal muscle have largely remained elusive. Here we demonstrate that sympathetic neurons make…”
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Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner by Schavinski, Aline Z, Reis, Natany G, Morgan, Henrique J N, Assis, Ana Paula, Moro, Matheus L, Valentim, Rafael R, Seni-Silva, Ana Carolina, Ramos, Ester S, Kettelhut, Isis C, Navegantes, Luiz C C

“…Recent studies have shown that maternal vitamin D deficiency (VDD) causes long-term metabolic changes in offspring. However, little is known about the impact…”
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Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation by Reis, Mouzarllem B., Rodrigues, Fernanda L., Lautherbach, Natalia, Kanashiro, Alexandre, Sorgi, Carlos A., Meirelles, Alyne F. G., Silva, Carlos A. A., Zoccal, Karina F., Souza, Camila O. S., Ramos, Simone G., Matsuno, Alessandra K., Rocha, Lenaldo B., Salgado, Helio C., Navegantes, Luiz C. C., Kettelhut, Ísis C., Cupo, Palmira, Gardinassi, Luiz G., Faccioli, Lúcia H.

“…Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede…”
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Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt by Gonçalves, Dawit A P, Silveira, Wilian A, Lira, Eduardo C, Graça, Flávia A, Paula-Gomes, Silvia, Zanon, Neusa M, Kettelhut, Isis C, Navegantes, Luiz C C

“…Although it is well known that administration of the selective β(2)-adrenergic agonist clenbuterol (CB) protects muscle following denervation (DEN), the…”
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Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats by Reis, Natany G., Assis, Ana P., Lautherbach, Natália, Gonçalves, Dawit A., Silveira, Wilian A., Morgan, Henrique J.N., Valentim, Rafael R., Almeida, Lucas F., Heck, Lilian C., Zanon, Neusa M., Koike, Tatiana E., Santos, Audrei R., Miyabara, Elen H., Kettelhut, Isis C., Navegantes, Luiz C.

“…Background Fetal stage is a critical developmental window for the skeletal muscle, but little information is available about the impact of maternal vitamin D…”
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α−Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles by Machado, Juliano, Silveira, Wilian A., Gonçalves, Dawit A., Schavinski, Aline Zanatta, Khan, Muzamil M., Zanon, Neusa M., Diaz, Mauricio Berriel, Rudolf, Rüdiger, Kettelhut, Isis C., Navegantes, Luiz C.

“…Although it is well established that a-calcitonin gene-related peptide (CGRP) stabilizes muscle-type cholinergic receptors nicotinic subunits (AChR), the…”
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β2-Adrenoceptors activation regulates muscle trophic-related genes following acute resistance exercise in mice by Abdalla-Silva, Ronaldo L., Zanetti, Gustavo O., Lautherbach, Natalia, Schavinski, Aline Zanatta, Heck, Lilian C., Gonçalves, Dawit A. P., Kettelhut, Isis C., Navegantes, Luiz C. C., Silveira, Wilian A.

“…Resistance exercise (RE) training and pharmacological stimulation of β 2 -Adrenoceptors (β 2 -ARs) alone can promote muscle hypertrophy and prevent muscle…”
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Mechanisms Involved in 3′,5′-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle by Gonçalves, Dawit A. P, Lira, Eduardo C, Baviera, Amanda M, Cao, Peirang, Zanon, Neusa M, Arany, Zoltan, Bedard, Nathalie, Tanksale, Preeti, Wing, Simon S, Lecker, Stewart H, Kettelhut, Isis C, Navegantes, Luiz C. C

“…Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was…”
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Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles by Lira, Eduardo C., Gonçalves, Dawit A.P., Parreiras-E-Silva, Lucas T., Zanon, Neusa M., Kettelhut, Isis C., Navegantes, Luiz C.C.

“…Phosphodiesterase (PDE) inhibition reduces skeletal muscle atrophy, but the underlying molecular mechanism remains unclear. We used microdialysis to…”
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Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism by Przygodda, Franciele, Manfredi, Leandro Henrique, Machado, Juliano, Gonçalves, Dawit A P, Zanon, Neusa M, Bonagamba, Leni G H, Machado, Benedito H, Kettelhut, Ísis C, Navegantes, Luiz C C

“…Although it is well known that chronic hypoxia induces muscle wasting, the effects of intermittent hypoxia on skeletal muscle protein metabolism remain…”
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Increased Glyceride–Glycerol Synthesis in Liver and Brown Adipose Tissue of Rat: In-Vivo Contribution of Glycolysis and Glyceroneogenesis by Chaves, Valéria E., Frasson, Danúbia, Garófalo, Maria A. R., Navegantes, Luiz C. C., Migliorini, Renato H., Kettelhut, Isis C.

“…We have previously shown that a high-protein, carbohydrate-free diet can decrease the production of glycerol-3-phosphate (G3P) from glucose and increase…”
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Epinephrine depletion exacerbates the fasting-induced protein breakdown in fast-twitch skeletal muscles by Graça, Flávia A, Gonçalves, Dawit A P, Silveira, Wilian A, Lira, Eduardo C, Chaves, Valéria Ernestânia, Zanon, Neusa M, Garófalo, Maria Antonieta R, Kettelhut, Isis C, Navegantes, Luiz C C

“…The physiological role of epinephrine in the regulation of skeletal muscle protein metabolism under fasting is unknown. We examined the effects of plasma…”
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cAMP‐dependent protein kinase inhibits FoxO activity and regulates skeletal muscle plasticity in mice by Silveira, Wilian A., Gonçalves, Dawit A., Machado, Juliano, Lautherbach, Natalia, Lustrino, Danilo, Paula‐Gomes, Silvia, Pereira, Marcelo G., Miyabara, Elen H., Sandri, Marco, Kettelhut, Isis C., Navegantes, Luiz C.

“…Although we have shown that catecholamines suppress the activity of the Ubiquitin‐Proteasome System (UPS) and atrophy‐related genes expression through a…”
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The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex by Katayama, Pedro L., Leirão, Isabela P., Kanashiro, Alexandre, Luiz, João P.M., Cunha, Fernando Q., Navegantes, Luiz C.C., Menani, Jose V., Zoccal, Daniel B., Colombari, Débora S.A., Colombari, Eduardo

“…•Systemic TNF-α increases carotid body afferent signalling to the brain.•TNF-α activates brain sympathetic networks and splanchnic sympathetic nerve…”
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Influence of β2-adrenergic selective agonist formoterol on the motor unit of a mouse model of a congenital myasthenic syndrome with complete VAChT deletion by Rossi, Leonardo, Mota, Bárbara I., Valadão, Priscila A.C., Magalhães-Gomes, Matheus P.S., Oliveira, Bruna S., Guatimosim, Silvia, Navegantes, Luiz C.C., Miranda, Aline S., Prado, Marco A.M., Prado, Vânia F., Guatimosim, Cristina

“…Congenital Myasthenic Syndromes (CMS) are a set of genetic diseases that affect the neuromuscular transmission causing muscular weakness. The standard…”
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Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth by Gonçalves, Dawit A., Silveira, Wilian A., Manfredi, Leandro H., Graça, Flávia A., Armani, Andrea, Bertaggia, Enrico, O´Neill, Brian T., Lautherbach, Natalia, Machado, Juliano, Nogara, Leonardo, Pereira, Marcelo G., Arcidiacono, Diletta, Realdon, Stefano, Kahn, C. Ronald, Sandri, Marco, Kettelhut, Isis C., Navegantes, Luiz Carlos C.

“…Background Stimulation of β2‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying…”
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Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo by Bonifacio, Annalisa, Mullen, Peter J., Mityko, Ileana Scurtu, Navegantes, Luiz C., Bouitbir, Jamal, Krähenbühl, Stephan

“…Simvastatin is effective and well tolerated, with adverse reactions mainly affecting skeletal muscle. Important mechanisms for skeletal muscle toxicity include…”
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Molecular basis of Period 1 regulation by adrenergic signaling in the heart by Jesus, Itamar C. G., Araújo, Flávia M., Mesquita, Thássio, Júnior, Nilton N. S., Silva, Mário M., Morgan, Henrique J. N., Silva, Kaoma S. C., Silva, Cleide L. A., Birbrair, Alexander, Amaral, Flávio A., Navegantes, Luiz C., Salgado, Helio C., Szawka, Raphael E., Poletini, Maristela O., Guatimosim, Silvia

“…The cardiac circadian clock is responsible for the modulation of different myocardial processes, and its dysregulation has been linked to disease development…”
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Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold by Morgan, Henrique J.N., Delfino, Heitor B.P., Schavinski, Aline Z., Malone, Samuel A., Charoy, Camille, Reis, Natany G., Assis, Ana P., Lautherbach, Natalia, Silveira, Wilian A., Heck, Lilian C., Guton, Dan, Domingos, Ana I., Kettelhut, Isis C., Montminy, Marc, Navegantes, Luiz C.C.

“…Although it is well established that hormones like glucagon stimulates gluconeogenesis via the PKA-mediated phosphorylation of CREB and dephosphorylation of…”
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Sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions by Przygodda, Franciele, Lautherbach, Natalia, Buzelle, Samyra Lopes, Goncalves, Dawit Albieiro, Assis, Ana Paula, Paula-Gomes, Sílvia, Garófalo, Maria Antonieta Rissato, Heck, Lilian Carmo, Matsuo, Flávia Sayuri, Mota, Ryerson Fonseca, Osako, Mariana Kiomy, Kettelhut, Isis C, Navegantes, Luiz C

“…The sympathetic nervous system (SNS) activates cAMP signaling and promotes trophic effects on brown adipose tissue (BAT) through poorly understood mechanisms…”
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