Search Results - "Navaratnarajah, Maithili"

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming by Buj, Raquel, Chen, Chi-Wei, Dahl, Erika S., Leon, Kelly E., Kuskovsky, Rostislav, Maglakelidze, Natella, Navaratnarajah, Maithili, Zhang, Gao, Doan, Mary T., Jiang, Helen, Zaleski, Michael, Kutzler, Lydia, Lacko, Holly, Lu, Yiling, Mills, Gordon B., Gowda, Raghavendra, Robertson, Gavin P., Warrick, Joshua I., Herlyn, Meenhard, Imamura, Yuka, Kimball, Scot R., DeGraff, David J., Snyder, Nathaniel W., Aird, Katherine M.

“…Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during…”
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Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle by Laufenberg, Lacee J., Pruznak, Anne M., Navaratnarajah, Maithili, Lang, Charles H.

“…The present study tested the hypothesis that sepsis-induced leucine (Leu) resistance in skeletal muscle is associated with a down-regulation of amino acid…”
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Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice by Steiner, Jennifer L, Pruznak, Anne M, Deiter, Gina, Navaratnarajah, Maithili, Kutzler, Lydia, Kimball, Scot R, Lang, Charles H

“…Sepsis decreases skeletal muscle protein synthesis in part by impairing mTOR activity and the subsequent phosphorylation of 4E-BP1 and S6K1 thereby controlling…”
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The role of the Ragulator complex in mediating sepsis-induced muscle atrophy by Laufenberg, Lacee, MD, Navaratnarajah, Maithili, MS, Pruznak, Anne, MS, Lang, Charles, PhD

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Alcohol-Induced Modulation of Rictor and mTORC2 Activity in C2C12 Myoblasts by Hong-Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Huber, Danuta S., Lang, Charles H.

“…Background:  The mammalian target of rapamycin (mTOR) kinase controls cell growth, proliferation, and metabolism through 2 distinct multiprotein complexes,…”
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Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes by Ahmed, Tamer A, Buzzelli, Mark D, Lang, Charles H, Capen, John B, Shumate, Margaret L, Navaratnarajah, Maithili, Nagarajan, Murali, Cooney, Robert N

“…During systemic inflammation, the liver becomes unresponsive to growth hormone (GH), resulting in decreased plasma insulin-like growth factor-I (IGF-I) with…”
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Acute alcohol intoxication antagonizes contraction‐induced mTOR signaling in skeletal muscle (702.1) by Steiner, Jennifer, Navaratnarajah, Maithili, Lang, Charles

“…Acute alcohol (ethanol; EtOH) intoxication impairs basal protein synthesis and mTOR signaling in skeletal muscle but whether EtOH also blunts…”
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FoxO1‐AMPK‐ULK1 Regulates Ethanol‐Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1‐PIK3C3 Complex by Hong‐Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.

“…Background Excessive alcohol (EtOH) consumption causes an imbalance in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a…”
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Alcohol Differentially Alters Extracellular Matrix and Adhesion Molecule Expression in Skeletal Muscle and Heart by Steiner, Jennifer L., Pruznak, Anne M., Navaratnarajah, Maithili, Lang, Charles H.

“…Background The production of fibrosis in response to chronic alcohol abuse is well recognized in liver but has not been fully characterized in striated muscle…”
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Mild Zinc Deficiency Augments Increased TNF‐α Expression But Not Decreased Muscle Protein Synthesis after Acute Sepsis by Crowell, Kristen, Navaratnarajah, Maithili, Kelleher, Shannon, Soybel, David, Lang, Charles

“…Abstract only Moderate Zinc (Zn) imbalances are common among the elderly and individuals with chronic inflammatory conditions such as obesity, diabetes and…”
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FoxO1‐ AMPK ‐ ULK 1 Regulates Ethanol‐Induced Autophagy in Muscle by Enhanced ATG 14 Association with the BECN 1‐ PIK 3C3 Complex by Hong‐Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.

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Adamts1 Mediates Ethanol-Induced Alterations in Collagen and Elastin via a FoxO1-Sestrin3-AMPK Signaling Cascade in Myocytes by Hong-Brown, Ly Q, Brown, CRandell, Navaratnarajah, Maithili, Lang, Charles H

“…A variety of stressors including alcohol (EtOH) are known to induce collagen production and fibrotic diseases. Matrix metalloproteinases (MMP) play an…”
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Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy by Lang, Charles H, Pruznak, Anne, Navaratnarajah, Maithili, Rankine, Kristina A, Deiter, Gina, Magne, Hugues, Offord, Elizabeth A, Breuillé, Denis

“…Muscle disuse atrophy is observed routinely in patients recovering from traumatic injury and can be either generalized resulting from extended bed rest or…”
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Activation of AMPK/TSC2/PLD by Alcohol Regulates mTORC1 and mTORC2 Assembly in C2C12 Myocytes by Hong-Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.

“…Background Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mammalian target of rapamycin complex (mTORC)1 and increased…”
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Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine by Hong-Brown, Ly Q, Brown, C Randell, Kazi, Abid A, Navaratnarajah, Maithili, Lang, Charles H

“…Leucine (Leu) and insulin both stimulate muscle protein synthesis, albeit at least in part via separate signaling pathways. While alcohol (EtOH) suppresses…”
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Role of PLD and PA in alcohol (EtOH)‐mediated mTOR signaling in C2C12 myocytes by Hong‐Brown, Ly Quang, Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H

“…Abstract only Previously, we reported that EtOH decreases muscle protein synthesis, with this being mediated by reduced mTORC1 and increased mTORC2 activities…”
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Skeletal muscle catabolism in trinitrobenzene sulfonic acid–induced murine colitis by Puleo, Frances, Meirelles, Katia, Navaratnarajah, Maithili, Fitzpatrick, Leo, Shumate, Margaret L, Cooney, Robert N, Lang, Charles H

“…Abstract The present study determined whether the muscle atrophy produced by colitis is associated with altered rates of muscle protein synthesis or…”
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Skeletal Muscle Catabolism in TNBS-Induced Murine Colitis by Puleo, Frances, Meirelles, Katia, Navaratnarajah, Maithili, Fitzpatrick, Leo, Shumate, Margaret L., Cooney, Robert N., Lang, Charles H.

“…The present study determined whether the muscle atrophy produced by colitis is associated with altered rates of muscle protein synthesis or degradation, as…”
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Nuclear factor-kappaB mediates the inhibitory effects of tumor necrosis factor-alpha on growth hormone-inducible gene expression in liver by Buzzelli, Mark D, Nagarajan, Murali, Radtka, John F, Shumate, Margaret L, Navaratnarajah, Maithili, Lang, Charles H, Cooney, Robert N

“…TNF inhibits serine protease inhibitor 2.1 (Spi 2.1) and IGF-I gene expression by GH in CWSV-1 hepatocytes. The current study describes construction of a…”
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Nuclear Factor-κB Mediates the Inhibitory Effects of Tumor Necrosis Factor-α on Growth Hormone-Inducible Gene Expression in Liver by Buzzelli, Mark D, Nagarajan, Murali, Radtka, John F, Shumate, Margaret L, Navaratnarajah, Maithili, Lang, Charles H, Cooney, Robert N

“…TNF inhibits serine protease inhibitor 2.1 (Spi 2.1) and IGF-I gene expression by GH in CWSV-1 hepatocytes. The current study describes construction of a…”
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